DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Brd8 and BAZ2B

DIOPT Version :9

Sequence 1:	NP_651685.2	Gene:	Brd8 / 43460	FlyBaseID:	FBgn0039654	Length:	872	Species:	Drosophila melanogaster
Sequence 2:	XP_024308593.1	Gene:	BAZ2B / 29994	HGNCID:	963	Length:	2259	Species:	Homo sapiens

Alignment Length:	915	Identity:	182/915 - (19%)
Similarity:	291/915 - (31%)	Gaps:	311/915 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 ILASAVSCSGDQNWITVSRTLKTICGNGSSNRPADWFSQKNCAMQYGNLLESVEATKRKKRSSES 90
            :|::..|.|       :.:|..|..|.|  ||..:....||..:.  ..::.::..|.:|::.||
Human   205 VLSTTASSS-------MGQTKSTSSGGG--NRKCNQEQSKNQPLD--ARVDKIKDKKPRKKAMES 258

  Fly    91 SAGVSSPATVETPTELLLRRLTEERQAEIKAQMRQDQETYRRIQREIESLQSDAVTEQELQ---- 151
            |:...|.:...:.|.      :|...:.....:.:|:|...:...|.|...||:.:|.:.:
Human   259 SSNSDSDSGTSSDTS------SEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSESEAQHKSNNQ 317

  Fly   152 -----------DMWLEIEKEQEARRIEEMKLENRMR----------------------EREQRKK 183
                       |.....||.||.|..:.:.|.:..:                      :..|.|:
Human   318 VLLHGISDPKADGQKATEKAQEKRIHQPLPLASESQTHSFQSQQKQPQVLSQQLPFIFQSSQAKE 382

  Fly   184 D-------------LASNWRNSSLAVKRSNQAADTTSVDMDV--EDINTSGNGKQQTGPSPLLTS 233
            :             |.||.:..||.    |||...|.:.:.|  .|:..:|| |..:..|.||||
Human   383 ESVNKHTSVIQSTGLVSNVKPLSLV----NQAKKETYMKLIVPSPDVLKAGN-KNTSEESSLLTS 442

  Fly   234 LLKSPTGNAPATPTPGGAAPAAGGTGSVARATAPTITSLLTSGPSSAVANQPVITMKSPTDAAFM 298
            .|:|.......      |.|:.......:::....|.:|.....:|:....|..|:::.....|:
Human   443 ELRSKREQYKQ------AFPSQLKKQESSKSLKKVIAALSNPKATSSSPAHPKQTLENNHPNPFL 501

  Fly   299 SRPITGPPASEASTTPTLERSPSQAAPTLSM--LLEKNMAAAKANESGSLVKPEGSGNQEQGVDE 361
            :..:.|...........::.:|........|  .:.:|:|||.:....|.|....||.:..|
Human   502 TNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENIAAASSTPFSSPVNLSTSGRRTPG--- 563

  Fly   362 ATSSAAGTADSDEADPNEAQLLEVFKNIDQIIDDIDIDMASVIDDEILKNVDDVVASPSNDKAEV 426
                            |:.                          .::.:...::.|...:||
Human   564 ----------------NQT--------------------------PVMPSASPILHSQGKEKA-- 584

  Fly   427 IDFEDKLDALKREQSKSSPASDKPKS-VELVIGSSDDSNDNIPLAAVASQESKDRGQSGGESTRG 490
              ..:.::.:| .|..|.||    || ||...|:..|    ||    :|::|:|
Human   585 --VSNNVNPVK-TQHHSHPA----KSLVEQFRGTDSD----IP----SSKDSED----------- 623

  Fly   491 TEDAESEPLTSEVAVEEIGETITIISTSSEDTAGSPPTKMEEDGATDSLPKKEDAAEDKSEQESS 555
                                       |:||.        |||...:.....||...|.|:.||.
Human   624 ---------------------------SNEDE--------EEDDEEEDEEDDEDDESDDSQSESD 653

  Fly   556 SQGQNKAGGSTDEPELIDHQATREAQSKSGKDTAGKPVTMQEKTTTQSAPVPVDLHDTDEESSSL 620
            |..::...||.:|.:      ..:.|.:|..||.|:..:|:...||.|...|         |.||
Human   654 SNSESDTEGSEEEDD------DDKDQDESDSDTEGEKTSMKLNKTTSSVKSP---------SMSL 703

  Fly   621 TDSSKHDDHPRS---AKAKPPALKLALDDSKSELELSGTPQPPSAPARTPLLRKLPHRDRSESPM 682
            |..|.    ||:   |||                       |.||||..        ...|:||.
Human   704 TGHST----PRNLHIAKA-----------------------PGSAPAAL--------CSESQSPA 733

  Fly   683 ---VDDDATTASDHSTARSTRRRCSSTPVIDSIPNSPASSEHTDDR-----------RETRAASK 733
               ......|:|.|| ..|.|||.                  ||:|           ||||..:
Human   734 FLGTSSSTLTSSPHS-GTSKRRRV------------------TDERELRIPLEYGWQRETRIRN- 778

  Fly   734 KLFLSIYAMLLDSKHAAPFKRPFHDEHAQRHADLCLRPMDFPTIKRNIDSGFIRSLSELHRDVLL 798
                              |......|.|. :|....:...:|.:.:.:....|..:|   ||
Human   779 ------------------FGGRLQGEVAY-YAPCGKKLRQYPEVIKYLSRNGIMDIS---RD--- 818

  Fly   799 MAHNVLVAYKPHTAQHKTARLFVQDCQ--AIKEFSQLPDVQA--GITATPVSNTGSLRADKSSGS 859
               |...:.|........||...|..|  .:||...:|.::|  |....| .|....||.:.|..
Human   819 ---NFSFSAKIRVGDFYEARDGPQGMQWCLLKEEDVIPRIRAMEGRRGRP-PNPDRQRAREESRM 879

  Fly   860 KARSG 864
            :.|.|
Human   880 RRRKG 884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Brd8	NP_651685.2	PaaSYMP	<105..188	CDD:291408	18/132 (14%)
		PHA03249	402..>582	CDD:223023	35/180 (19%)
		Bromo_brd8_like	729..833	CDD:99939	18/105 (17%)
BAZ2B	XP_024308593.1	Nucleoporin_FG2	42..>226	CDD:330420	7/29 (24%)
		HAT_MBD	761..833	CDD:238691	15/100 (15%)
		TPH	903..>1089	CDD:316391
		DDT	1117..1179	CDD:214726
		WSD	1400..>1432	CDD:317927
		WSD	<1740..1779	CDD:317927
		PHD_BAZ2B	1995..2043	CDD:277100
		Bromo_BAZ2A_B_like	2128..2224	CDD:99935
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900