DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Brd8 and Brd8

DIOPT Version :9

Sequence 1:	NP_651685.2	Gene:	Brd8 / 43460	FlyBaseID:	FBgn0039654	Length:	872	Species:	Drosophila melanogaster
Sequence 2:	XP_008770251.2	Gene:	Brd8 / 291691	RGDID:	1307003	Length:	1206	Species:	Rattus norvegicus

Alignment Length:	1029	Identity:	250/1029 - (24%)
Similarity:	403/1029 - (39%)	Gaps:	286/1029 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSAGVQERLQLSRMPLDTWSKREQLILASAVSCSGDQNWITVSRTLKTICGNGSSNRPADWFSQK 65
            |:.|..:...||..|.:.||.||:|.|||:|..||||||::|||.:|.....|   ||.||||||
  Rat     1 MATGTGKHKLLSTGPTEPWSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPG---RPPDWFSQK 62

  Fly    66 NCAMQYGNLLESVEATKRKKRSSESSAGVSSPATVETPTELLLRRLTEERQAEIKAQMRQDQETY 130
            :||.||..|||:.|..|||:.....        .|||..::::|:||.||..|:|..:::.||.|
  Rat    63 HCASQYSELLETTETPKRKRGEKGE--------VVETVEDVIVRKLTAERVEELKKVIKETQERY 119

  Fly   131 RRIQREIESLQSDAVTEQELQDMWLEIEKEQEARRIEEMKLENRMREREQRKKDLASNWRNSSLA 195
            ||::|:.|.:|:..: :..|.::..:|..::        |||....|.:::..|.|...|.   |
  Rat   120 RRLKRDAELIQAGHM-DSRLDELCSDIAMKK--------KLEEEEAEVKRKATDAAYQARQ---A 172

  Fly   196 VKRSNQAADTTSVDMDVEDINTSGN---------------------------------------- 220
            ||...:...|..|...::..:..|:
  Rat   173 VKTPPRRLPTVMVRSPIDSASPGGDYPLGDLTPTTMEEATSGVTPGTLPSTPVTSFPGIPDTLPP 237

  Fly   221 ----------------------GKQQT-GPSPLLTSLLKS----PTG----NAPATPTP------ 248
                                  |::.| .|||||:.|||.    ||.    |....|.|
  Rat   238 GSAPLEAPMTPVTDDSPQKKMLGQKATPPPSPLLSELLKKGSLLPTSPRLVNESEMPVPSGHLSS 302

  Fly   249 -------GGAAPAAGGTGSVARAT-----------APTITSLLTSGPS---------SAVANQPV 286
                   ||..|...| |.:..||           |||::.||.:||:         :.||::|.
  Rat   303 TGVLLEVGGVLPMIHG-GDIQPATSAVAASPAASGAPTLSRLLEAGPTQFSTPLPSFTTVASEPP 366

  Fly   287 ITMKSP-----TDAAFMSRP-ITGPPASEASTTPTLERSPSQAAP-------------------- 325
            :.:..|     :.|..:..| :..|.::.|.:||......||..|
  Rat   367 VKLVPPPVESVSQATIVMMPALPAPSSAPAVSTPESVAPVSQPEPCVPLEAVGDPQTVTVSMDSS 431

  Fly   326 TLSMLLEKNMAAAKANESGSLVKPEGSGNQEQGVDEATSSAAGTADSDEADPNEAQLLEVFKNID 390
            .:||::  |....:...||....|.||         ...|..|..|.|.|:..:..:....:.:|
  Rat   432 EISMII--NSIKEECFRSGVAEAPGGS---------KAPSIDGKEDLDLAEKMDIAVSYTGEELD 485

  Fly   391 -QIIDDIDIDMASVIDDEILKNVDDVVASPSNDKAEVIDFEDKLDALKREQSKSSPAS------- 447
             :.:.||    .::|:|::            :|..||:|......||...:....|.|
  Rat   486 FETVGDI----IAIIEDKV------------DDHPEVLDVAAVEAALSFCEENDDPQSLPGPWEH 534

  Fly   448 ------DKPKSVELVIGSSDDSNDNIPLAA---VASQESKDRGQSGGESTRGTEDAESEPLTSEV 503
                  |||                :||.|   ...||..|           .|::|::.:...|
  Rat   535 PIQQERDKP----------------VPLPAPEMTVKQERLD-----------FEESETKGIHELV 572

  Fly   504 AVEEIGETITIIST-------SSEDTAGSPPTKMEEDGATDSLPKKEDAAEDKSEQ-ESSSQGQ- 559
            .:.:.|..|.:..|       .:|..||.        |...||...|..::|..|: .||:.|:
  Rat   573 DIRDSGVEIKVEPTEPEPGMSGAEIVAGV--------GPVPSLEPPELRSQDLDEEPRSSAAGEM 629

  Fly   560 NKAGGSTDEPE-----LIDHQATREAQSKSGKDTAGKPVTMQEKTTTQSAPVPVDLHDTDEESSS 619
            .:|.||:.:.|     .:..:|:.|  |.........|:....:..||.   ..::.|:.:|.|.
  Rat   630 GEADGSSGKGEERPLPAVKTEASPE--SMLSPSHGSNPIEDPLEAETQH---KFEMSDSLKEESG 689

  Fly   620 LTDSSKHDDHPRSAKAKPPALKLA-LDDSKSELELSGTPQPPSAPARTPLLRKLPHRDRSESPMV 683
            ....|:..|.|...:.:....:.| |::.|.|.:..|               .|...| :|.|:.
  Rat   690 TIFGSQIKDAPGEEEEEDGVSEAASLEEPKEEDQGEG---------------YLSEMD-NEPPVS 738

  Fly   684 DDDATTASDHSTARSTRRRCSSTPVIDSIPNSPASSEH---TDDRRETRAAS--KKLFLSIYAML 743
            :.|...:..::|.:       |..:.||||:|||||:.   ::|:...:|..  ||..:.::...
  Rat   739 ESDDGFSIHNATLQ-------SHTLGDSIPSSPASSQFSVCSEDQEAIQAQKIWKKAIMLVWRAA 796

  Fly   744 LDSKHAAPFKRPFHDEHAQRHADLCLRPMDFPTIKRNIDSGFIRSLSELHRDVLLMAHN-VLVAY 807
            .:.::|..|.:|..|:.|..:..:..||||..|||:||::|.|||.:|..||::||..| |:...
  Rat   797 ANHRYANVFLQPVTDDIAPGYHSIVQRPMDLSTIKKNIENGLIRSTAEFQRDIMLMFQNAVMYNS 861

  Fly   808 KPHTAQHKTARLFVQDCQAIKEF--SQL--PDVQAGITATPVSNTGSLRADKSS 857
            ..|...|....:.....:.|::|  :||  ...::||:|..:....|.|...:|
  Rat   862 SDHDVYHMAVEMQRDVLEQIQQFLATQLIMQTSESGISAKSLRGRDSTRKQDAS 915

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Brd8	NP_651685.2	PaaSYMP	<105..188	CDD:291408	23/82 (28%)
		PHA03249	402..>582	CDD:223023	43/209 (21%)
		Bromo_brd8_like	729..833	CDD:99939	32/108 (30%)
Brd8	XP_008770251.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353210
Domainoid	1	1.000	101	1.000	Domainoid score	I6801
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	151	1.000	Inparanoid score	I4282
OMA	1	1.010	-	-		QHG46231
OrthoDB	1	1.010	-	-		D1509761at2759
OrthoFinder	1	1.000	-	-		FOG0004061
OrthoInspector	1	1.000	-	-		otm45154
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15398
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5075
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.960