DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Brd8 and Baz1b

DIOPT Version :9

Sequence 1:	NP_651685.2	Gene:	Brd8 / 43460	FlyBaseID:	FBgn0039654	Length:	872	Species:	Drosophila melanogaster
Sequence 2:	NP_035844.2	Gene:	Baz1b / 22385	MGIID:	1353499	Length:	1479	Species:	Mus musculus

Alignment Length:	857	Identity:	152/857 - (17%)
Similarity:	271/857 - (31%)	Gaps:	292/857 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 PATVETPTELL---LRRLTEERQAEIKAQMRQDQETYRRIQREIESLQSDAVTEQELQDMWL--- 155
            |.|:.:.:||:   |||...:..:|       ..||       .::..|....:.|:||.:|
Mouse   683 PLTLHSVSELVRLCLRRCDVQEDSE-------GSET-------DDNKDSTPFEDNEVQDEFLEKL 733

  Fly   156 ------EIEKEQEARRIEEM--------KLENRMREREQRKKDLASNWRNSSLAVKRSNQAADTT 206
                  |:..|::.|.:..:        .:::.|..|:|...:|   |:.....:|..|......
Mouse   734 ETSEFFELTSEEKLRILTALCHRILMTYSVQDHMETRQQVSAEL---WKERLAVLKEENDKKRAE 795

  Fly   207 SVDMDVEDINTSGNGKQQT--GPSPLLTSLLKSPTGNAPATPTPGGAAPAAGGTGSVARATAPTI 269
            .......:.....|||::.  |.......::|                        :.:......
Mouse   796 KQKRKEMEARNKENGKEENVLGKVDRKKEIVK------------------------IEQQVEVEA 836

  Fly   270 TSLLTSGPSSAVANQPVITMKSPTDAAFMSRPITGPPASEASTTPTLERSPSQAAPTLSMLLEKN 334
            ..::     |||.::.:::|:     |...|.|     .|..|...|||...:..      :.|:
Mouse   837 DDMI-----SAVKSRRLLSMQ-----AKRKREI-----QERETKVRLEREAEEER------MRKH 880

  Fly   335 MAAA-KANESGSLVKPEGSGNQEQGVDEATSSAAGTADSDEADPNEAQLLE------------VF 386
            .||| ||              .::|:.:|......|....:.:.|...|..            |.
Mouse   881 KAAAEKA--------------FQEGIAKAKLVLRRTPIGTDRNHNRYWLFSNEVPGLFIEKGWVH 931

  Fly   387 KNIDQIIDDIDIDMASVIDDE----------------------ILKNVDDVVASPSNDKAEVIDF 429
            .:||........|.:::.||:                      .|:.|:..|.....:...:.|.
Mouse   932 NSIDYRFKHHRKDHSNLPDDDYCPRSKKANLGKNASVNAHHGPALEAVETTVPKQGQNLWFLCDS 996

  Fly   430 EDKLDAL-------------------KREQ--SKSSPASDKPKSVELVIGSSDDSNDNIPLAAVA 473
            :.:||.|                   ||.|  :.|...:.||   .|.:.|.|.:.:.:......
Mouse   997 QKELDELLSCLHPQGIRESQLKERLEKRYQEITHSIYLARKP---NLGLKSCDGNQELLNFLRSD 1058

  Fly   474 SQESKDRGQSGGES-TRGTEDAESEPLTSEVAVEEIGETITIISTS--SEDTAG--SPPTKMEED 533
            ..|...|.|.||.. ..||.:.|:..::.| .:::.||.:..:..|  .:...|  :|..|..:.
Mouse  1059 LIEVATRLQKGGLGYMEGTSEFEARVISLE-KLKDFGECVIALQASVIKKFLQGFMAPKQKKRKL 1122

  Fly   534 GATDSLPKKEDAAEDKSEQESSSQGQNKAGGSTDEPELIDHQATREAQS---------------- 582
            .:.|| .|.|:..|:|...|.:     |...:.::.:    .|.||||:
Mouse  1123 QSEDS-TKSEEVDEEKKMVEEA-----KVASALEKWK----TAIREAQTFSRMHVLLGMLDACIK 1177

  Fly   583 --------------KSGKD--------------------------------TAGKPVTMQ----- 596
                          |.|:|                                .|.:|.|.:
Mouse  1178 WDMSAENARCKVCRKKGEDDKLILCDECNKAFHLFCLRPALYEVPDGEWQCPACQPPTARRNSRG 1242

  Fly   597 ----EKTTTQSAPVPVDLHDTDEESSSLTDSSKHDDHPRSAKAKPPALKLALDDSKSELELSGTP 657
                |::|::.:  ..|....:||.....:..:.|......:.:|   :..:...:|.:..:...
Mouse  1243 RNYTEESTSEGS--EGDESGEEEEEEEEEEEEEEDYEVAGLRLRP---RKTIRGKQSVIPAARPG 1302

  Fly   658 QPP---SAPARTPLLRKLPHRDRSESPMVDDDATTASDHSTARSTRRRCSSTPVIDSIPNSPASS 719
            :||   |.|||    |..|..|    |.|||...     .|.|.:||:.......:.|.:.
Mouse  1303 RPPGKKSHPAR----RSRPKDD----PEVDDLVL-----QTKRISRRQSLELQKCEDILHK---- 1350

  Fly   720 EHTDDRRETRAASKKLFLSIYAMLLDSKHAAPFKRPFHDEHAQRHADLCLRPMDFPTIKRNIDSG 784
                                   |:..:.:.||:.|...:.|:.:.|:...||||.||:.....|
Mouse  1351 -----------------------LVKYRFSWPFREPVTRDEAEDYYDVIEHPMDFQTIQNKCSCG 1392

  Fly   785 FIRSLSELHRDV 796
            ..||:.|...|:
Mouse  1393 NYRSVQEFLTDM 1404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Brd8	NP_651685.2	PaaSYMP	<105..188	CDD:291408	20/102 (20%)
		PHA03249	402..>582	CDD:223023	45/227 (20%)
		Bromo_brd8_like	729..833	CDD:99939	17/68 (25%)
Baz1b	NP_035844.2	WAC_Acf1_DNA_bd	21..120	CDD:287503
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	146..212
		C motif	207..213
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	302..333
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	376..433
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	448..472
		DDT	605..669	CDD:214726
		WHIM1	725..770	CDD:292246	7/44 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	789..813		4/23 (17%)
		WHIM2	900..928	CDD:292247	3/27 (11%)
		WHIM3	991..1029	CDD:292248	7/37 (19%)
		PHD_BAZ1B	1186..1231	CDD:277098	3/44 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1231..1324		20/105 (19%)
		Bromo_WSTF_like	1340..1436	CDD:99937	18/92 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1451..1479
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900