DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Brd8 and BPTF

DIOPT Version :9

Sequence 1:	NP_651685.2	Gene:	Brd8 / 43460	FlyBaseID:	FBgn0039654	Length:	872	Species:	Drosophila melanogaster
Sequence 2:	XP_005257207.1	Gene:	BPTF / 2186	HGNCID:	3581	Length:	3158	Species:	Homo sapiens

Alignment Length:	766	Identity:	149/766 - (19%)
Similarity:	265/766 - (34%)	Gaps:	199/766 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 GDQNWIT---VSRTLKTICGNGSSNRPADWFSQKNCAMQYGNLLESV-EATKRKKRSSESSAGV- 94
            |..:||:   |.|.:..:.||.:.|........||      |:.|:: |:.|||...|.....:
Human  1032 GGWSWISKTHVYRFVPKLPGNTNVNYRKSLEGTKN------NMDENMDESDKRKCSRSPKKIKIE 1090

  Fly    95 ----------SSPATVETPTELLLRRLTEERQAEIKAQMRQDQETYRRIQREIESLQSDAVTEQE 149
                      |..|......|:.:.::||::..::|..:  |.::.:..:.|...:..|..||..
Human  1091 PDSEKDEVKGSDAAKGADQNEMDISKITEKKDQDVKELL--DSDSDKPCKEEPMEVDDDMKTESH 1153

  Fly   150 LQDMWLEIEKEQEARRIEEMKLENRMREREQRKKDLASNWRNSSLAVKRSNQAADTTSVDMDVED 214
            :..        ||:.:::.:.:......|...||...|: :...|..:|..|.  |......:|.
Human  1154 VNC--------QESSQVDVVNVSEGFHLRTSYKKKTKSS-KLDGLLERRIKQF--TLEEKQRLEK 1207

  Fly   215 INTSGN----GKQQTGPSPLLTSLLKSPTGNAPATPTPGGAAPAAGGTGSVARATAPTITSLLTS 275
            |...|.    ||..|..|..|:.                                :|.||.....
Human  1208 IKLEGGIKGIGKTSTNSSKNLSE--------------------------------SPVITKAKEG 1240

  Fly   276 GPSSAVANQ--PVITMKSPTDAAFMSRPITGPPASEASTTPTLERSPSQAAPTLSMLLEKNMAAA 338
            ..|.::..:  |......|.|.      |.|  .||:.::......||.   |.:.|..|:
Human  1241 CQSDSMRQEQSPNANNDQPEDL------IQG--CSESDSSVLRMSDPSH---TTNKLYPKD---- 1290

  Fly   339 KANESGSLVKPEGSGNQEQGVDEATSSAAGTADSDEADPNEAQLLEVFKNIDQIIDDIDIDMASV 403
            :..:..|:..||....::..::...........|...:|::::.    |..|..|||..:..|..
Human  1291 RVLDDVSIRSPETKCPKQNSIENDIEEKVSDLASRGQEPSKSKT----KGNDFFIDDSKLASADD 1351

  Fly   404 IDDEILKN--------VDDVVAS-----------PSNDK-----AEVIDFEDKLDALKREQSKSS 444
            |...|.||        .|.:|:|           .:||:     :..:|||.||.......|...
Human  1352 IGTLICKNKKPLIQEESDTIVSSSKSALHSSVPKSTNDRDATPLSRAMDFEGKLGCDSESNSTLE 1416

  Fly   445 PASDKPKSVELVIGSSDD-----SNDNIPLAAVASQESKDRGQSGGESTRGTEDAE-SEPLTSE- 502
            .:||   :|.:...|.:|     ||::|      |::.:.|.|          |.| .|||..|
Human  1417 NSSD---TVSIQDSSEEDMIVQNSNESI------SEQFRTREQ----------DVEVLEPLKCEL 1462

  Fly   503 VAVEEIGETITIISTSSEDTAGSPPT---KMEE---DGATDSLPKKEDAAEDKSE-QESSSQGQN 560
            |:.|..|.....:.....:..|..|:   |:||   :..:|.:..|....:..:| :||..:||.
Human  1463 VSGESTGNCEDRLPVKGTEANGKKPSQQKKLEERPVNKCSDQIKLKNTTDKKNNENRESEKKGQR 1527

  Fly   561 ----KAGGSTDEPEL-IDHQATRE-AQSK--SGK-------------DTAGKPVTMQEKTTTQSA 604
                :..|..::|:: :..:..:| ::|:  ||.             :...|.:|::|.......
Human  1528 TSTFQINGKDNKPKIYLKGECLKEISESRVVSGNVEPKVNNINKIIPENDIKSLTVKESAIRPFI 1592

  Fly   605 PVPVDLHDTDEESSSLTDSSKHDDHPRSAKAKPPALKLALDDSKSELELSGTPQPPSAPARTPLL 669
            ...|.:.|.:|.:||.|.|.                .|:..|::.....|              |
Human  1593 NGDVIMEDFNERNSSETKSH----------------LLSSSDAEGNYRDS--------------L 1627

  Fly   670 RKLPHRDRSESPMVDDDATTASDHSTARSTRRRCSSTPVIDSIPNSPASSE 720
            ..||....|:|......:.:..:.::..........|..:..:.:||.:||
Human  1628 ETLPSTKESDSTQTTTPSASCPESNSVNQVEDMEIETSEVKKVTSSPITSE 1678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Brd8	NP_651685.2	PaaSYMP	<105..188	CDD:291408	14/82 (17%)
		PHA03249	402..>582	CDD:223023	50/223 (22%)
		Bromo_brd8_like	729..833	CDD:99939
BPTF	XP_005257207.1	DDT	241..297	CDD:280886
		WHIM1	339..388	CDD:292246
		PHD1_BPTF	392..434	CDD:277034
		Med15	2217..>2598	CDD:255446
		TNG2	2742..2972	CDD:227367
		PHD2_3_BPTF	2923..2969	CDD:277035
		PHD2_3_BPTF	2981..3027	CDD:277035
		Bromo_gcn5_like	3043..3143	CDD:99941
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810