DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Brd8 and Bptf

DIOPT Version :9

Sequence 1:	NP_651685.2	Gene:	Brd8 / 43460	FlyBaseID:	FBgn0039654	Length:	872	Species:	Drosophila melanogaster
Sequence 2:	XP_006532738.1	Gene:	Bptf / 207165	MGIID:	2444008	Length:	3158	Species:	Mus musculus

Alignment Length:	906	Identity:	171/906 - (18%)
Similarity:	314/906 - (34%)	Gaps:	268/906 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 KREQLILASAVSCSGDQNW---------ITVSRTLKTICGNGSSNRPADWFSQKNCAMQYGNLLE 76
            ||..|.....::.:|:..|         :|:| ||:.......||.|:. |...|.|....|.::
Mouse   885 KRRHLAHKFCLTPAGEFKWNGSVHGSKVLTIS-TLRLTITQLESNIPSS-FLHPNWASHRANWIK 947

  Fly    77 SVEATKRKKRSSESSA--------GVSSPATVETPTELLLRRLT----EERQAEIKAQMRQDQET 129
            :|:...:.:..:.:.|        .|..|...|:.....|.|:|    ||::...|.:.:|::|
Mouse   948 AVQMCSKPREFALALAILECAVKPVVMLPIWRESLGHTRLHRMTSIEREEKEKVKKKEKKQEEE- 1011

  Fly   130 YRRIQREIESLQSDAVTEQELQDMWLE----IEKEQEARRIEEMKLENRMREREQRKKDLASNWR 190
                    |::|         |..|::    ::.:...::.||.::....          ..:|.
Mouse  1012 --------ETMQ---------QATWVKYTFPVKHQVWKQKGEEYRVTGYG----------GWSWI 1049

  Fly   191 NSSLAVKRSNQAADTTSVD----MDVEDINTSGN-GKQQTGPSPLLTSLLKS-------PTGNAP 243
            :.:...:...:....|:|:    :|....||..| .:.:...||.....:|:       .|.:|.
Mouse  1050 SKTHVYRFLPKLPGNTNVNYRKPLDGAKNNTDENKDESEKRKSPRSPKKMKTECDSEQGETRDAD 1114

  Fly   244 ATPTPGGAAPAAGGTGSVARATAPTITSLLTSGPSSAVANQPV---ITMKSPTDAAFM-SRPITG 304
            ||   .|||..|.............:..||.|....:...:|:   .|:|:.:..:.: |..:..
Mouse  1115 AT---AGAAAGAMELSKEPEKKDQDVKELLDSDNDKSFKEEPMEIDDTIKTESHVSSLESTEVDV 1176

  Fly   305 PPASEASTTPTLERSPSQAAPTLSMLLEKNMAAAKANESGSLVK------PEGSGNQEQGVDEAT 363
            ...||.....|..:..:::: .|..|||:.:......|...|.|      .:|:|....|..:::
Mouse  1177 VNVSEGFHLRTSYKKKTKSS-KLDGLLERRIRQFTLEEKQRLEKLKLESGVKGAGKPPMGALKSS 1240

  Fly   364 SSAAGTADSDEA----------DPNEAQLLEVFKNI-------------------------DQII 393
            |.:.|:..:.|.          .|:.:|...|...:                         ||::
Mouse  1241 SESPGSTKASEGHQGDSLRQEQSPSSSQASTVDLGLGGSQSDPLVLGISPPSLSTHKPDPKDQVL 1305

  Fly   394 DDIDIDMAS---VIDDEILKNVDDVVASPSNDKAEVIDFEDKLDALKREQSKSSPASDKPKSVEL 455
            ||:.|....   ...:.:..::|..::.|:....|       |...|.|.:.||....||.|.:.
Mouse  1306 DDVSIQSPGPNCQRQNSVESDLDARISEPAGKGLE-------LSQTKTEVTDSSSDDSKPTSADD 1363

  Fly   456 V---------IGSSDDSN-------DNIPLAAVASQESKDR----------GQSGGESTRGT--- 491
            |         :.|.|||:       ..:|.:...|...:|.          |:.||:|...:
Mouse  1364 VGILICKSRKLHSQDDSSTVVSSSKSTLPASVPKSPRDRDARAFSKAVDFDGRLGGDSEYSSTLE 1428

  Fly   492 ---------EDAE-------SEPLTSE--VAVEEIGETI-----TIISTSSED------------ 521
                     :.||       |...||:  :|.|:.||::     .::|.|:|:
Mouse  1429 NSSDNMCIRDSAEEDMVVQNSSEATSKRFIAPEQGGESVESTKCQVVSKSTENCEDKLQGKVTEA 1493

  Fly   522 ---TAGSPPTKMEE---DGATDSLPKKEDAAEDKSE-QESSSQGQ-----------NKAGG---- 564
               ..|..|.|.||   :..||.:..:.......|| :||..:||           :||.|
Mouse  1494 NGKKLGQHPPKPEERAVNRCTDQVSLRHSVDRKNSEPRESEKKGQKANKFQINGKDSKAKGYLKG 1558

  Fly   565 -------------STDEPEL--IDHQATREAQSKSGKDTAGKP-----VTMQEKTTTQSAPVPVD 609
                         |..||::  |:.......:|.:||::|.||     :.|:|.:         :
Mouse  1559 PGTKDGSDGKVVSSAVEPKVNNINKVIPGNTKSLAGKESAAKPFINGDIIMEELS---------E 1614

  Fly   610 LHDTDEESSSLTDSSKHDDHPRSAKAKPPALKLALDDSKSELELSGTPQPPSAPARTPLLRKLPH 674
            .:.::..|.||:.|....:|.......|                 .|.:..|....||   :.|.
Mouse  1615 QNTSETNSYSLSSSDAKGNHQDGLHTLP-----------------STKESASTQVITP---RAPC 1659

  Fly   675 RDRSESPMVDDDATTASD-----HSTARSTRRRCSSTPVID--SIPNSPASSEHTDDRRET 728
            .||:....|:|..|.:.:     .|..|:......|...:|  .:|:|...:.:.:.:|:|
Mouse  1660 PDRNSLSQVEDMETESPEVKRVIPSPVRTGEGSNLSKGFMDDNGLPSSKDENVNGESQRKT 1720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Brd8	NP_651685.2	PaaSYMP	<105..188	CDD:291408	14/90 (16%)
		PHA03249	402..>582	CDD:223023	55/283 (19%)
		Bromo_brd8_like	729..833	CDD:99939	171/906 (19%)
Bptf	XP_006532738.1	DDT	253..309	CDD:367184
		WHIM1	356..393	CDD:373966
		PHD1_BPTF	404..446	CDD:277034
		WSD	468..536	CDD:373967
		MDN1	<578..749	CDD:227596
		DUF5585	<2038..2345	CDD:375359
		Med15	<2246..>2609	CDD:312941
		TPH	2696..>2836	CDD:372768
		PHD2_3_BPTF	2923..2969	CDD:277035
		PHD2_3_BPTF	2981..3027	CDD:277035
		Bromo_gcn5_like	3043..3143	CDD:99941
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810