DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Brd8 and EP300

DIOPT Version :9

Sequence 1:NP_651685.2 Gene:Brd8 / 43460 FlyBaseID:FBgn0039654 Length:872 Species:Drosophila melanogaster
Sequence 2:NP_001420.2 Gene:EP300 / 2033 HGNCID:3373 Length:2414 Species:Homo sapiens


Alignment Length:732 Identity:149/732 - (20%)
Similarity:254/732 - (34%) Gaps:194/732 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   117 AEIKAQMRQDQETY-RRIQREI-ESLQSDAVTEQELQDMWLEIEKEQEARRIEEMKLENRMRERE 179
            |.:|.:..::...| |:::.:: ||..:.|.....|.:...:|:||          ||.:.|.|.
Human   598 AALKDRRMENLVAYARKVEGDMYESANNRAEYYHLLAEKIYKIQKE----------LEEKRRTRL 652

  Fly   180 QRKKDLASNWRNSSLAVKRSNQAADTTSVDMDVEDINTSGNGKQQTGPSPLLTSLLKSPTGNAPA 244
            |::..|.:              ||....|.|:        .|.....|.|.:||       |.| 
Human   653 QKQNMLPN--------------AAGMVPVSMN--------PGPNMGQPQPGMTS-------NGP- 687

  Fly   245 TPTPGGAAPAAGGTGSVARATAPTITSLLTSGPSSAVANQPVITMKSPTDAAFMSRPITGPPASE 309
            .|.|...      .|||.....|.||      |.|.:.....::|..|        ||.      
Human   688 LPDPSMI------RGSVPNQMMPRIT------PQSGLNQFGQMSMAQP--------PIV------ 726

  Fly   310 ASTTPTLERSPSQAAPTLSMLLEKNMAAAKANESGSLVKPEGSGNQEQGVDEATSSAAGTADSDE 374
            ...||.|:.....|.|                  |:|..|.|.|.:.|                 
Human   727 PRQTPPLQHHGQLAQP------------------GALNPPMGYGPRMQ----------------- 756

  Fly   375 ADPNEAQLLEVFKNIDQIIDDIDIDMASVIDDEILKNVDDVVASPSNDKAEVIDFEDKLDALKRE 439
            ...|:.|.|...:...|.:                 ||.::..:||:.:|.|            .
Human   757 QPSNQGQFLPQTQFPSQGM-----------------NVTNIPLAPSSGQAPV------------S 792

  Fly   440 QSKSSPASDKPKSVELVIGSSDDSN---DNIPLAAVASQESKDRGQSGGESTRGTE---DAESEP 498
            |::.| :|..|.:..::...|..|:   ..:|..|: .|.|.....|...:...|.   .|:..|
Human   793 QAQMS-SSSCPVNSPIMPPGSQGSHIHCPQLPQPAL-HQNSPSPVPSRTPTPHHTPPSIGAQQPP 855

  Fly   499 LTSEVAVEEIGETITIISTSSEDTAGSPPTKMEEDGATDSLPKKEDAAEDKSEQESSSQGQNKAG 563
            .|:   :.....|...:....:..|..||.:......|..||::             .|....|.
Human   856 ATT---IPAPVPTPPAMPPGPQSQALHPPPRQTPTPPTTQLPQQ-------------VQPSLPAA 904

  Fly   564 GSTDEPELIDHQATREAQSKSGK-DTAGKPVTMQEKTTTQSAP-VPVDLHDTDEESSSLTDSSKH 626
            .|.|:|:    |..|..||.:.. .|...|:...:..|..|.| |.::...::..|:|.|:.:. 
Human   905 PSADQPQ----QQPRSQQSTAASVPTPTAPLLPPQPATPLSQPAVSIEGQVSNPPSTSSTEVNS- 964

  Fly   627 DDHPRSAKAKPPALKLALDDSKSELELSGTPQPPSAPARTPLLRKLPHRDRSESPMVD--DDATT 689
                ::...|.|:.::.: ::|.|::     ||..|..:.        .|.|||.:.|  .::|.
Human   965 ----QAIAEKQPSQEVKM-EAKMEVD-----QPEPADTQP--------EDISESKVEDCKMESTE 1011

  Fly   690 ASDHSTARSTR-RRCSSTPVIDSIPNSPASSEHTDDRRETRAASKKLFLSIYAMLLDSKHAAPFK 753
            ..:.||...|. :.....|...:..:|||..:......:.....:.|..::.|:......:.||:
Human  1012 TEERSTELKTEIKEEEDQPSTSATQSSPAPGQSKKKIFKPEELRQALMPTLEALYRQDPESLPFR 1076

  Fly   754 RPFHDE--HAQRHADLCLRPMDFPTIKRNIDSGFIRSLSELHRDVLLMAHNVLVAYKPHTAQHKT 816
            :|...:  ....:.|:...|||..||||.:|:|..:...:...|:.||.:|..:      ...||
Human  1077 QPVDPQLLGIPDYFDIVKSPMDLSTIKRKLDTGQYQEPWQYVDDIWLMFNNAWL------YNRKT 1135

  Fly   817 ARLFVQDCQAIKE-FSQ 832
            :|:: :.|..:.| |.|
Human  1136 SRVY-KYCSKLSEVFEQ 1151

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Brd8NP_651685.2 PaaSYMP <105..188 CDD:291408 17/72 (24%)
PHA03249 402..>582 CDD:223023 35/185 (19%)
Bromo_brd8_like 729..833 CDD:99939 26/107 (24%)
EP300NP_001420.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..29
Interaction with RORA. /evidence=ECO:0000269|PubMed:9862959 2..149
Interaction with ALX1. /evidence=ECO:0000269|PubMed:12929931 2..139
Nuclear localization signal. /evidence=ECO:0000255 11..17
Med15 98..>280 CDD:312941
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 133..157
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 196..235
zf-TAZ 347..414 CDD:366931
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 482..518
KIX 566..646 CDD:366953 12/57 (21%)
Med15 <648..>854 CDD:312941 63/327 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 729..1050 81/425 (19%)
TonB 961..>1064 CDD:223880 21/121 (17%)
CRD1, mediates transcriptional repression 1017..1029 2/11 (18%)
Bromo_cbp_like 1051..1158 CDD:99927 26/108 (24%)
RING_CBP-p300 1170..1242 CDD:276805
PHD_p300 1243..1277 CDD:277116
HAT_KAT11 1306..>1517 CDD:369758
Interaction with histone. /evidence=ECO:0000269|PubMed:18273021 1397..1399
Acetyl-CoA binding. /evidence=ECO:0000269|PubMed:24819397 1398..1400
Acetyl-CoA binding. /evidence=ECO:0000269|PubMed:24819397 1410..1411
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1520..1578
Binding region for E1A adenovirus 1572..1818
ZZ_CBP 1668..1708 CDD:239077
ZnF_TAZ 1729..1807 CDD:214717
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1833..1924
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1980..2010
Med15 1984..>2408 CDD:312941
Interaction with HTLV-1 Tax 2003..2212
Creb_binding 2005..2098 CDD:370251
Interaction with NCOA2. /evidence=ECO:0000269|PubMed:15731352 2041..2240
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2094..2163
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2186..2237
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2267..2385
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5076
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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