DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Brd8 and Kat2b

DIOPT Version :9

Sequence 1:	NP_651685.2	Gene:	Brd8 / 43460	FlyBaseID:	FBgn0039654	Length:	872	Species:	Drosophila melanogaster
Sequence 2:	NP_064389.2	Gene:	Kat2b / 18519	MGIID:	1343094	Length:	813	Species:	Mus musculus

Alignment Length:	855	Identity:	166/855 - (19%)
Similarity:	260/855 - (30%)	Gaps:	283/855 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   219 GNGKQQTGPSP------LLTSLLKSPTGNAPATP-TPGGAAPAAGGTGSVARA-------TAPTI 269
            |.|.....|:|      .|.:...|.....|||. ...|.|...||.||...|       :||..
Mouse     6 GAGSPALPPAPPHGSPRTLATAAGSSASCGPATAVAAAGTAEGPGGGGSARIAVKKAQLRSAPRA 70

  Fly   270 TSLLTSGPSSAVANQPVIT---MKSPTDAAFMSRPITGPPASE-----ASTTPTLERSPSQA--- 323
            ..|...|..||...:....   .|:|       .|...||..:     .|.|.:. ||.|.|
Mouse    71 KKLEKLGVYSACKAEESCKCNGWKNP-------NPSPTPPRGDLQQIIVSLTESC-RSCSHALAA 127

  Fly   324 -----------------------------------APT------LSMLLEKN-MAAAKANESGSL 346
                                               |.|      |..||.|: :...|....|||
Mouse   128 HVSHLENVSEEEMDRLLGIVLDVEYLFTCVHKEEDADTKQVYFYLFKLLRKSILQRGKPVVEGSL 192

  Fly   347 VK--PEGSGNQEQGVD----------------------------------EATSSAAGTADSDEA 375
            .|  |....:.||||:                                  ||.|.....:.:|:.
Mouse   193 EKKPPFEKPSIEQGVNNFVQYKFSHLPSKERQTTIELAKMFLNRINYWHLEAPSQRRLRSPNDDI 257

  Fly   376 D---PNEAQLLEVFKNIDQIIDDID-IDMASVIDDEILKNVDDVV-------ASPSNDKAE---- 425
            .   .|..:.| .:.|:.|..|.:. .:...|....:|::|..::       |....||..
Mouse   258 SGYKENYTRWL-CYCNVPQFCDSLPRYETTKVFGRTLLRSVFTIMRRQLLEQARQEKDKLPLEKR 321

  Fly   426 ---VIDFEDKLDALKRE-QSKSSPASDK----------PKSVELVIGSSDDSNDNIPLAAVASQE 476
               :..|...|..|:.| .|::||..|:          |..::.||..        |:...|...
Mouse   322 TLILTHFPKFLSMLEEEVYSQNSPIWDQDFLSASSRTSPLGIQTVISP--------PVTGTALFS 378

  Fly   477 SKD---------------RGQSGGESTRG----------TEDAESEPLTSEVAVEEIGETITIIS 516
            |..               ||.||.|:..|          .|:|:...:..::.||.|.|.::.|:
Mouse   379 SNSTSHEQINGGRTSPGCRGSSGLEANPGEKRKMNNSHAPEEAKRSRVMGDIPVELINEVMSTIT 443

  Fly   517 TSSEDTAG--SPPTK-MEEDGATDS---LPKKEDAAEDKSEQESSSQGQNK------AGGSTDEP 569
                |.||  .|.|. :....|.|.   |.::....|......|.:|..||      .|    ..
Mouse   444 ----DPAGMLGPETNFLSAHSARDEAARLEERRGVIEFHVVGNSLNQKPNKKILMWLVG----LQ 500

  Fly   570 ELIDHQATRE-----------------AQSKSGKDTAG----------------KPVTMQEKTTT 601
            .:..||..|.                 |..|.|:...|                ..||..|:...
Mouse   501 NVFSHQLPRMPKEYITRLVFDPKHKTLALIKDGRVIGGICFRMFPSQGFTEIVFCAVTSNEQVKG 565

  Fly   602 QSAPVPVDL---HDTDEESSSLTDSSKH-----DDHPRSAKAKPPALKLA--LDDSKSELELSGT 656
            ....:...|   |...|..:.||.:.::     .....|.:.|.|..|..  :.|.:. ..|.|.
Mouse   566 YGTHLMNHLKEYHIKHEILNFLTYADEYAIGYFKKQGFSKEIKIPKTKYVGYIKDYEG-ATLMGC 629

  Fly   657 PQPPSAP---------ARTPLLRKLPHRDRSESPMVDDDATTASDHSTARSTRRRCSSTPVIDSI 712
            ...|..|         .:..:::||..|.:::...|....:...|     ..|:    .| |:||
Mouse   630 ELNPQIPYTEFSVIIKKQKEIIKKLIERKQAQIRKVYPGLSCFKD-----GVRQ----IP-IESI 684

  Fly   713 PN------SPASSEHTDDRRETRAASKKLFLSIYAMLLDSK---HAAPFKRPFHDEHAQRHADLC 768
            |.      .|:..|.:.:.::    .::|:.::..:|...|   :|.||..|.....|..:.::.
Mouse   685 PGIRETGWKPSGKEKSKEPKD----PEQLYSTLKNILQQVKNHPNAWPFMEPVKRTEAPGYYEVI 745

  Fly   769 LRPMDFPTIKRNIDSGFIRSLSELHRDVLLMAHNVLVAYKPHTAQHKTARLFVQDCQAIKE---F 830
            ..|||..|:...:.:.:..|......|:..:..|......|.:..:|        |.:|.|   |
Mouse   746 RFPMDLKTMSERLRNRYYVSKKLFMADLQRVFTNCKEYNPPESEYYK--------CASILEKFFF 802

  Fly   831 SQLPDVQAGI 840
            |::.  :||:
Mouse   803 SKIK--EAGL 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Brd8	NP_651685.2	PaaSYMP	<105..188	CDD:291408
		PHA03249	402..>582	CDD:223023	51/258 (20%)
		Bromo_brd8_like	729..833	CDD:99939	22/109 (20%)
Kat2b	NP_064389.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55		14/48 (29%)
		PCAF_N	56..307	CDD:283997	46/259 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	380..423		8/42 (19%)
		COG5076	468..807	CDD:227408	66/367 (18%)
		Acetyltransf_1	531..603	CDD:278980	11/71 (15%)
		Acetyl-CoA binding. /evidence=ECO:0000250\|UniProtKB:Q92830	555..557		0/1 (0%)
		Acetyl-CoA binding. /evidence=ECO:0000250\|UniProtKB:Q92830	562..568		0/5 (0%)
		Acetyl-CoA binding. /evidence=ECO:0000250\|UniProtKB:Q92830	593..596		0/2 (0%)
		Bromo_gcn5_like	708..807	CDD:99941	22/108 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810