DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Brd8 and baz-2

DIOPT Version :9

Sequence 1:	NP_651685.2	Gene:	Brd8 / 43460	FlyBaseID:	FBgn0039654	Length:	872	Species:	Drosophila melanogaster
Sequence 2:	NP_498673.3	Gene:	baz-2 / 176078	WormBaseID:	WBGene00001470	Length:	1390	Species:	Caenorhabditis elegans

Alignment Length:	907	Identity:	170/907 - (18%)
Similarity:	308/907 - (33%)	Gaps:	267/907 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 KREQLILASAVSCSGDQNWITVSRTLKTICGNGSSNRPADWFSQKNCAMQYGNLLESVEATKRKK 85
            |.:|...|:|.:.:...:..|.|.:  .|.|. |....|.|  |:...||   .|:.:..|.:|.
Worm   109 KEKQKAAAAAAAAAAKASASTSSAS--AIPGL-SPEMLAAW--QQAIQMQ---ALQQMMMTPQKS 165

  Fly    86 RSSES-----------SAGVSSPATV----ETPTELLLRRLTEERQAE---------------IK 120
            :..|:           .|||:|.::.    .||:.......:....|.               :.
Worm   166 QMEEAIKKMMDMAKKKPAGVASTSSASTSSSTPSTSSASITSSNNNAANNAASNMMNNVMWQLVA 230

  Fly   121 AQMRQDQETYRRIQREIESLQSDAVTEQELQDMWLEIEKEQEARRIEEMKL---------ENRMR 176
            |||:|.|      |::.:..|..|...::.:::..:.:|||:.:..::.::         .|..:
Worm   231 AQMQQKQ------QQQQKDTQKKADQAKKAKELAKQQQKEQDVKNKQQEEILKFLMAQHQLNHQK 289

  Fly   177 EREQRKKDLASNWRNSSLAVKRSNQAADTTSVDMDVEDINTSGNGKQQTGPSPLLTSLLKSPTGN 241
            :.|:::.|.|      :||.|  ..||...:::.|..:     .||:..      .::|:.|...
Worm   290 KHEKKQADAA------ALAAK--VLAAHRAALESDSPE-----EGKKTN------EAMLRLPLQL 335

  Fly   242 APATPTPGGAAPAAGGTGSVARATAPTITSLLTSGPSSAVANQPVITMKSPTDAAFMSRPITG-- 304
            .....|...:..:||..|.|: ..||....|.|.........:..|...:..:..|.::.:.|
Worm   336 GWRRQTCVRSIASAGVKGDVS-YFAPCGKKLSTYSEVVRYLTKNSIHYITRDNFLFNTKLVIGEF 399

  Fly   305 --PPASEASTTPTLERSPSQAAPTLSMLLEK--NMAAAKANESGSLVK--PEGSGNQEQGVDEAT 363
              |..:||..|        |.....:|..|.  |....:.|    ::|  |:...:...||.|..
Worm   400 IVPKQTEADET--------QQEREFAMFTEDDINKELTRLN----VLKFVPKIQASTSNGVHEDD 452

  Fly   364 SSAAGTADSDE-ADPNEAQLLEVFKNIDQIIDDI--------DIDMASVID---DEILKNVDDVV 416
            ...:...:.|| .||:|..        |:..:::        .:|...:.:   |::|.|::||.
Worm   453 IKMSKIEEPDEPLDPSELN--------DEFTEELVHSQIMSNGVDECKIREREADDLLVNINDVR 509

  Fly   417 ASPSNDKA--EVIDFEDKLDALKREQSKSS-------PASDKPKSVELVIGSSDDSND------- 465
            ..|...:.  :.:..:...|||...:...:       .....||...|..|...|:|.
Worm   510 HLPDFSRIGNQCLSSQGFADALMVHEFVQNFGHVLGIDLEIAPKLESLCAGLDGDANHAEQTLQL 574

  Fly   466 -----NIPLAAVASQESKDRGQSGGE-------------------STRGTEDAESEPLTSEVAVE 506
                 .:.|........|..||.|||                   ..||.|  .|:||.
Worm   575 TRQLLRLALEFPGMGNEKRFGQGGGEMGLDRENFSEVMRLFLIDKGKRGEE--LSQPLL------ 631

  Fly   507 EIGETITIISTSSEDTAGSPPTKMEEDGATDSLPKKEDAAEDKSEQESSSQ--GQNKAGGSTDEP 569
                |...:|.|.|..|.......:|...:.::..:.|...|:..:....:  .:.||
Worm   632 ----TCNFLSISPEQKASILAFLCDELVCSRNVVTEIDKNLDEISRLKGEKWMREGKA------- 685

  Fly   570 ELIDHQATREAQSKSGKDTAGKPVTMQEKTTTQSAPVPVDLHDTDEESSSLTDSSKHDDHPRSAK 634
                 :|.|.|:||...|.  |.|.::|:..          |::|.|..:..|:      |:.|.
Worm   686 -----RALRSARSKKKNDE--KVVVVKEEQN----------HESDSEPPTRPDT------PKKAT 727

  Fly   635 AKPPALKLALDDSKSELELSGTPQPPSAPAR-----TPLLRK---LPHRDRSESPMVDDDATTAS 691
            ..||.:.              :..|.||..:     ||.|.:   |..::.|.| :...|:....
Worm   728 VAPPTVV--------------SVSPVSAAQQQQRKFTPGLGQCEVLTEQEESMS-LQQMDSLIGD 777

  Fly   692 DHSTARSTRRRCSSTPVIDSIPNSPASSE----------HTDDRRETRAASKKLFLSIYAMLLDS 746
            .|..|::..::...|.:  .|.:.|..::          |||                 .::::|
Worm   778 LHQEAQNINQKIHDTGL--KIRSFPFGTDRFHRNYWMLAHTD-----------------KVIIES 823

  Fly   747 KHAAPFKRPF--HDEHAQRHADLCLRPMDFPTIKR-------NIDSGFIRSLSELHRDVLLM 799
            ........|.  .:|:|.:         |.||:::       .||...|..:.:|..||:|:
Worm   824 LATTSVNNPACNANEYASK---------DPPTLEQRVPGACETIDLDVIACVEDLVDDVVLL 876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Brd8	NP_651685.2	PaaSYMP	<105..188	CDD:291408	16/106 (15%)
		PHA03249	402..>582	CDD:223023	41/224 (18%)
		Bromo_brd8_like	729..833	CDD:99939	14/80 (18%)
baz-2	NP_498673.3	FlgD	35..88	CDD:281896
		HAT_MBD	328..401	CDD:238691	14/73 (19%)
		DDT	524..>564	CDD:295426	7/39 (18%)
		WHIM1	622..670	CDD:292246	13/59 (22%)
		WHIM3	899..931	CDD:292248
		PHD_BAZ2A_like	1102..1146	CDD:277020
		PHD	1155..1199	CDD:214584
		Bromo_BAZ2A_B_like	1278..1374	CDD:99935
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900