DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Brd8 and athp-2

DIOPT Version :9

Sequence 1:	NP_651685.2	Gene:	Brd8 / 43460	FlyBaseID:	FBgn0039654	Length:	872	Species:	Drosophila melanogaster
Sequence 2:	NP_494767.2	Gene:	athp-2 / 173769	WormBaseID:	WBGene00019217	Length:	1412	Species:	Caenorhabditis elegans

Alignment Length:	994	Identity:	181/994 - (18%)
Similarity:	316/994 - (31%)	Gaps:	325/994 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 SKREQLILASAVSCS------GD--QNWITVSRTLKTICGNGSSNRPADWFSQKNCAMQYGNLLE 76
            :.||::.|.:|.:|.      ||  ::...:...::.|.|....:.|.||       |....:|.
Worm   533 NNREEVYLINAQNCDPAHVTHGDSIRDLSDLHFKIRKIHGKSVRHLPVDW-------MTLTEVLR 590

  Fly    77 SV---------EATKRKK-------RSSESSA---GVSSPATVETPTELLLRRLTEERQAEIKAQ 122
            .:         .||.|.:       |..|..|   ....|..:|....|.:..|....:.||...
Worm   591 LIFETSGYYTGMATHRHRLYARGNFRGYEDPAYEFRTRHPGIMEKLRTLTVFDLEAPERLEIVKT 655

  Fly   123 MRQDQETYRRIQREIESLQSDAVTEQELQDMWLEIEKEQEARRIEEMKLENRMREREQRKKDLAS 187
            :.....||.:.:..:|..|::.|                      |:|       |||:|   ..
Worm   656 LIYQLLTYSKFRGHLEQRQNELV----------------------ELK-------REQKK---LK 688

  Fly   188 NWRNSSLAVKRSNQAADTTSVDMDVEDINTSGNGKQQTGPSPLLTSLLKSPTGNAPATPTPGGAA 252
            .|                        |:...|    :...:.||..|       |||
Worm   689 AW------------------------DVGQEG----EANAARLLLEL-------APA-------- 710

  Fly   253 PAAGGTGSVARATAPTITSLLTSGPSSAVANQPVITMKSPTDAAFM-SRPITGPPASEASTTPTL 316
             .|.|...|.....|.:...|.:  .....|:.....|...||..: |.|.......|..|...|
Worm   711 -GASGAPDVKEQKEPPVVRRLKA--HIKAINEGRRYDKEDLDAIVLESVPYASLSLDEIVTAREL 772

  Fly   317 ERSP---------SQAAPTLSMLLEKNMAAAKA------NESGSLVKPEGSGNQEQGV--DEATS 364
            ::|.         |:.....|.:.:..:.:.:|      .|:.|.:..|.:..||.|:  ||
Worm   773 QKSEFKILMDSLISKMFQIYSKISDIRLGSDRAYRRYIVMENLSAILVETATFQELGIYCDE--- 834

  Fly   365 SAAGTADSDEADP-----NEAQLLEVFKNIDQIIDDIDIDMASVIDDE----------------- 407
                  .|...||     ||.|  |||      |...::|...|..||
Worm   835 ------PSIIDDPLNLLENEHQ--EVF------ICTGNMDTCRVHGDESNNWTRWSYIRDREQFE 885

  Fly   408 -ILKNVD-------DVVASPSNDKAEVIDFEDKLDALKREQSKSSPASDKPKSVELVIGSSDDSN 464
             :||:::       :::...:..:..:::..::.:.|..|:..    .|:.||..:....:....
Worm   886 QLLKSLNPRGNREVELLEELNEYRPSLLEILEETERLHEEEED----EDEWKSQFMTNDPNPGDT 946

  Fly   465 DNIPLAA------VASQESKDRGQSG----------------------------------GESTR 489
            .||...|      :..:|..|:||.|                                  ||.:.
Worm   947 YNIDWDAEMRDLLLDFEEKIDQGQMGSIEKIFECNRIEWRDNLKESGNVCMLLNEDISIFGEISV 1011

  Fly   490 GTEDAE--SEPLTSEVAVEEIGETITI-------ISTSSEDTAGSPPTKM-----------EEDG 534
            ..|::|  |:.:...:|...|.::|.:       ||.:.::.....|:::           |...
Worm  1012 NLEESEHFSDSMKLAIAFYMIIKSIHLKFIKAPYISPNKDEHGNLKPSELFIRWQRALLECESHS 1076

  Fly   535 ATDSLPKKEDAA--EDKSEQESSSQG-QNKAGG----------------------STDEP----- 569
            |........:.:  .|||..:...:. :.||..                      ::|.|
Worm  1077 ALSLFISTFEGSIKWDKSRLQGKCRSCRRKAAAHDLVLCSECDNCYHLKCAKLDVNSDAPADWMC 1141

  Fly   570 -------ELIDHQATRE-------AQSKSGKDTAGKPVTMQEKTTTQSAPVPVDLHDTDEESSSL 620
                   ..::::|.|.       |:|.|.:|.|...:::.: ..::.||...:    ..||.|.
Worm  1142 TSCRAQQRKVENEAKRMARDDDQLAESSSQEDVAIGNISISD-NFSEIAPKTAE----PAESCST 1201

  Fly   621 TDSSKHDDHPRSAKAKPPALK----------LALDDSKSELELSGTPQPPSAPARTPLLRKLPHR 675
            ..:||.....|:|..:  |:|          |:|.:.||...:..||.  ..|.|...:|..
Worm  1202 PTTSKEPPTIRTASGR--AVKRVHYSDIHEGLSLKNRKSNGSMPVTPS--ERPVRNVSVRIF--- 1259

  Fly   676 DRSESPMVDDDATTASDHSTARSTRRRCSSTPVIDSIPNSPASSEHTDDRRETRAASKKLFLSIY 740
                 .:.:::..|..|.|...:||:|  .||   :...|..|:..|:|.......:.|..:::.
Worm  1260 -----DVENENVLTDEDDSDGENTRKR--KTP---TSKKSVTSTPTTNDISRVIIPNIKEKMTLI 1314

  Fly   741 AMLLDSKHAA------PFKRPFHDEHAQRHADLCLRPMDFPTIKRNIDSGFIRSLSELHRDVLLM 799
            ..||  |.|.      ||.:|...:....:.|:..|||:..|:...|.........|:..|..|:
Worm  1315 ETLL--KEAMRQECSWPFLQPVDSKEVPDYYDVIKRPMNLRTMMNKIKQRIYNKPIEVRNDFQLI 1377

  Fly   800 AHNVLVAYKPHTAQHKTAR 818
            ..|.....:|....:|.:|
Worm  1378 LSNCETYNEPENEIYKLSR 1396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Brd8	NP_651685.2	PaaSYMP	<105..188	CDD:291408	15/82 (18%)
		PHA03249	402..>582	CDD:223023	41/308 (13%)
		Bromo_brd8_like	729..833	CDD:99939	21/96 (22%)
athp-2	NP_494767.2	WAC_Acf1_DNA_bd	23..123	CDD:402251
		DDT	457..524	CDD:214726
		WHIM1	629..671	CDD:406127	8/41 (20%)
		WSD	795..897	CDD:406128	25/118 (21%)
		PHD	1100..1144	CDD:214584	4/43 (9%)
		BROMO	1306..1409	CDD:197636	21/93 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900