Protein Alignment Brd8 and pcaf-1

DIOPT Version :9

• Sequence 1: NP_651685.2
• Gene: Brd8 / 43460
• FlyBaseID: FBgn0039654
• Length: 872
• Species: Drosophila melanogaster
• Sequence 2: NP_491173.1
• Gene: pcaf-1 / 171920
• WormBaseID: WBGene00021636
• Length: 767
• Species: Caenorhabditis elegans
• Alignment Length: 891
• Identity: 174/891 - (19%)
• Similarity: 283/891 - (31%)
• Gaps: 255/891 - (28%)

  Fly    13 RMPLDTWSKREQLIL-----ASAVSCSG---------------------DQNWITVSRTLKTI-- 49
            |..||  .||.||..     |....|.|                     :.::..::|.|:|:
 Worm     4 RDSLD--EKRRQLTYFTSCNAGTCQCRGFRPVLNHEDETVERRATRAERENDFAPMTRDLETLGS 66

  Fly    50 --------CGNGSS--NRPADWFSQKNCAMQYGNLLESVEATKRKKRSSESSAGVSSPATVETPT 104
                    ||:..|  ..|..:.||::.. .|.:.:..::..  ....||......|..|:....
 Worm    67 EEIIECRTCGHSISFHAEPLKYLSQEDLD-TYTDQISDLQTC--CSELSEIDPSHESLQTLYITM 128

  Fly   105 ELLLRRLTEERQAEI----KAQMRQDQ-ETYRRIQREIESLQSDAVTEQELQDMWLEIEKEQEAR 164
            ::||:.|......::    |.....:. ..|..:::.|.|...|...:|.|.::......|....
 Worm   129 QILLKSLRTLTPVDVPFIGKPNFEPESLSPYILVKKFIASRPVDNAEKQRLAEIGTLFLTEMNHW 193

  Fly   165 RIEEM-----KLENRMREREQR----KKDLASNWRNSSLAVKRSNQAADTTSVDMDVEDINTSGN 220
            ::|..     ||...:.:.:.|    :.|...|.....::.|:..      :||:..|...|
 Worm   194 KLEGFQSLADKLNVPLEQGKYRMMYVRMDYYVNMPAKYVSFKQFQ------TVDIFGEKFTT--- 249

  Fly   221 GKQQTGPSPLLTSLLKSPTGNAPATPTPGGAAPAAGGTGSVARATAPTITS--LLTSGPSS---- 279
                |..:.|:..|   .|||.    ||.|.:.:.....|....|..|...  |.|..|.|
 Worm   250 ----TFCNYLINVL---NTGNY----TPFGLSESDLEENSEDLITFATDLRRYLETEDPQSTSTT 303

  Fly   280 -----AVANQPVI----TMKSPTDAAFMSRPITGPPASEASTTPTLE-----RSPSQAAPTLSML 330
                 :::.:.||    ..|.|||.:..|.|      .|.||:|..|     :.||.:|.. |..
 Worm   304 NRRKDSISTEDVILKYVKRKKPTDHSESSSP------RELSTSPVEEPRRRKKEPSSSAKK-SPE 361

  Fly   331 LEKNMAAAKANESGSL---VKPEGSGNQEQGVDEATSSAAGTADSDEADPN-----EAQLLEVFK 387
            .|::||..:     ||   :|.||                   |.|..:|.     ||...||.:
 Worm   362 TEESMALLR-----SLIRAIKFEG-------------------DLDAMEPKTKVEFEALNTEVSR 402

  Fly   388 NIDQIIDDIDIDMASVIDDEILKNVDDVVASPSNDKAEVIDFEDKLDALKREQSKSSPASDKPKS 452
            .:..:.:    :.:.:|:..::.|..|    |.....:::    .|..|:.......|...|...
 Worm   403 GLSALQE----EESGLIEFRVIGNDLD----PFQHHEQLV----HLVELQNLFGAQLPKMPKEYV 455

  Fly   453 VELVIGSSDDSNDNIPLAAVASQESKDRGQSGGESTRGTEDAESEPLTSEVAVEEIGETITIIST 517
            ..|:.   |..:.|:.:.      .:|.|..||...|      :.|....|      |.:....|
 Worm   456 TRLIF---DSRHQNMVIL------KRDMGVIGGICFR------TFPSRGFV------EIVFCAIT 499

  Fly   518 SSEDTAGSPPTKMEEDGATDSLPKKEDAAEDKSEQESSSQGQNKAGGSTDEPELIDHQATREAQS 582
            :.|...|.....|..  ..|.:.|                  ||          |.|..|...:.
 Worm   500 AMEQVKGYGTHLMNH--CKDYMIK------------------NK----------IYHMLTYADEF 534

  Fly   583 KSGKDTAGKPVTMQEKTTTQSAPVPVDLHDT-------DEESSSLTDSSKHDDHPRSAKAKPPAL 640
            ..|            ..|.|.....::::||       :.|.::|.....   ||:.:..|.|
 Worm   535 AIG------------YFTKQGFSEKLEINDTVYQGWIKEYEGATLMGCHL---HPQISYTKFP-- 582

  Fly   641 KLALDDSKSELEL-SGTPQPPSAPARTPLLRKLPHRDRSESPMVDDDATTASDHSTARSTRRRCS 704
                |.||....| .|......|.:|..:...|.|..|..||.:                 ....
 Worm   583 ----DFSKGIQALHCGYKSENGAESRGKVFGGLEHLFRESSPQL-----------------LELR 626

  Fly   705 STPVIDSIPNSPASSEHTDDRRETRAASKKLFLSIYAMLLDSKHAAPFKRPFHDEHAQRHADLCL 769
            ..|..||:.....|..|.|:|.:  :...|:. :|...|...|:|.||..|...:....:.|...
 Worm   627 KVPGTDSLKMHKKSCYHLDERDD--SLDSKIG-AILKKLTADKNAWPFASPVDVKEVPEYYDHIK 688

  Fly   770 RPMDFPTIKRNIDSG-------FIRSLSELHRDVLLMAHNVLVAYK 808
            .|:||.|::..:...       ||..|:.|.::..:......|.||
 Worm   689 HPIDFKTMQEKLKRKAYTHQHLFIADLNRLFQNCYVFNGAEAVYYK 734

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Brd8	NP_651685.2	PaaSYMP	<105..188	CDD:291408	16/96 (17%)
		PHA03249	402..>582	CDD:223023	30/179 (17%)
		Bromo_brd8_like	729..833	CDD:99939	20/87 (23%)
pcaf-1	NP_491173.1	PCAF_N	9..247	CDD:283997	42/246 (17%)
		COG5076	408..735	CDD:227408	80/431 (19%)
		Acetyltransf_1	476..544	CDD:278980	20/121 (17%)
		Bromo_gcn5_like	650..748	CDD:99941	20/86 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900