DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Brd8 and Baz2a

DIOPT Version :9

Sequence 1:	NP_651685.2	Gene:	Brd8 / 43460	FlyBaseID:	FBgn0039654	Length:	872	Species:	Drosophila melanogaster
Sequence 2:	XP_011241580.1	Gene:	Baz2a / 116848	MGIID:	2151152	Length:	1888	Species:	Mus musculus

Alignment Length:	831	Identity:	154/831 - (18%)
Similarity:	266/831 - (32%)	Gaps:	244/831 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   214 DINTSG---------NGKQQTGPSPLLTSLLKSPT-----------------GNAPATPT----- 247
            |:|.:|         :|...:.|....||.|..|.                 ||....|.
Mouse    50 DVNVNGLSTVSHTTTSGILNSAPHSSSTSHLHHPNVAYDCLWNYSQYPSANPGNNLKDPPLLSQF 114

  Fly   248 PGGAAPAAGGTGSVARATAPTITSLLTSGPSSAVANQPVITMKSPTDAAFMSRPI---------- 302
            |||..|..|..|...:.::|:..:.|.:|.....||    ..:||....|.|:.:
Mouse   115 PGGQYPLNGILGGNRQPSSPSHNTNLRAGSQEFWAN----GTQSPMGLNFDSQELYDSFPDQNFE 175

  Fly   303 ---TGPPA--SEASTTPTLERSPSQAAPTLSMLLEKNMAAAKANESGSLVKPEGSG-------NQ 355
               .|||:  :...|:|.|..|....||:..:..:.:...|...|..|:|...|:|       .:
Mouse   176 VMPNGPPSFFTSPQTSPMLGSSIQTFAPSQDVSSDIHPDEAAEKELTSVVAENGTGLVGSLELEE 240

  Fly   356 EQ------GVDEATSSAAGTADSDEA---DPNEAQLLEVFKNIDQIIDDIDIDMASVIDDEILKN 411
            ||      |.:.:.||..........   ||..:.|.:.....||:.|      ..::.::.|:.
Mouse   241 EQPELKMCGYNGSVSSVESLHQEVSVLVPDPTVSCLDDPSHLPDQLED------TPILSEDSLEP 299

  Fly   412 VDDVVAS-PSN------DKAEVIDFEDKL-------------DALKREQSKSSPASDKPKSVEL- 455
            .|.:.|: |.:      |.||::..||||             .||....:.|..|.|...|..:
Mouse   300 FDSLAAAEPVSGSLYGIDDAELMGAEDKLPLEGNPVISALDCPALSNANAFSLLADDSQTSASIF 364

  Fly   456 -------VIGSSDDSNDNIPLAAVASQESKD-RGQSGGESTRGTEDAESEPLTSEV--------- 503
                   |:|.|...:::..|.:.:..|.:: ..||.......||.|..:|.::::
Mouse   365 VSPTSPPVLGESVLQDNSFGLNSCSDSEQEEIETQSSNFQRPLTEPAPDQPPSTQLHPAVSPTAS 429

  Fly   504 ------AVEEIGETITIISTS--------SEDTAGSP--PTKMEEDGATDSL------PKKEDAA 546
                  |..||...::.:::|        :...|.||  |....|...|..:      |:...||
Mouse   430 PAASLTASAEISPAVSPVASSPVPPEVFVAVSPASSPALPAISLEASMTTPVTSPQGSPEPSPAA 494

  Fly   547 ----------------EDKSEQESSSQGQNKAGGSTD-------EPELI----DHQATREAQSKS 584
                            :.::::|.::.|.....||.|       .||.:    .|...||.:.|.
Mouse   495 AFQTVSPARKNVSSAPKARADREETTGGAVAVSGSGDVLKRRIATPEEVRLPLQHGWRREVRIKK 559

  Fly   585 GK----------DTAGK-------------------------------PV--TMQEKTTTQSAP- 605
            |.          ...||                               ||  ..:|:.|.:...
Mouse   560 GSHRWQGETWYYGPCGKRMKQFPEVIKYLSRNVVHSVRREHFSFSPRMPVGDFFEERDTPEGLQW 624

  Fly   606 VPVDLHDTDEESSSLT---------DSSKHDDHP--RSAKAKPPALKLALDDSKSELELSGTPQP 659
            |.:...:......::|         :.:|:.:.|  :..:.:||.:|:
Mouse   625 VQLSAEEIPSRIQAITGKRGRPRNNEKAKNKEVPKVKRGRGRPPKIKM----------------- 672

  Fly   660 PSAPARTPLLRKLPHRDRSESPMVDDDAT--TASDHSTARSTRRRCSSTPVIDSIPN----SPAS 718
            |....:|.  .:||.:..::..:.:||..  |.:.....:..:|..|.|||.....|    ...|
Mouse   673 PELLNKTD--NRLPKKLETQEILSEDDKAKMTKNKKKMRQKVQRGESQTPVQGQARNKRKQDTKS 735

  Fly   719 SEHTDDRRETRAASKKLFLSIYAMLLDSKHAAPFKRPFHDEHAQRHADLCLRPMDFPTIKR---- 779
            .:..|.:::.:|..:|:......:....|.....|.....:...|....|.......|.||
Mouse   736 LKQKDTKKKLKAEKEKMKTKQEKLKEKVKREKKEKVKAKGKEGPRARPSCRADKTLATQKRLEEQ 800

  Fly   780 NIDSGFIRSLSELHRDVLLMAHNVLVAYKPHTAQHKTARLFVQDCQAIKEF 830
            ......:..:.:...|:.|..|..|..:........::|.| .||..|.||
Mouse   801 QRQQAILEEMKKPTEDMCLSDHQPLPDFTRIPGLTLSSRAF-SDCLTIVEF 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Brd8	NP_651685.2	PaaSYMP	<105..188	CDD:291408
		PHA03249	402..>582	CDD:223023	51/266 (19%)
		Bromo_brd8_like	729..833	CDD:99939	20/106 (19%)
Baz2a	XP_011241580.1	PHA03307	269..>517	CDD:223039	47/253 (19%)
		PRK07003	<408..>534	CDD:235906	22/125 (18%)
		HAT_MBD	542..614	CDD:238691	9/71 (13%)
		DDT	840..902	CDD:214726	6/12 (50%)
		WSD	1101..>1132	CDD:373967
		Atrophin-1	<1151..>1421	CDD:367360
		WSD	<1424..1458	CDD:373967
		PHD_BAZ2A	1663..1709	CDD:277099
		Bromo_BAZ2A_B_like	1781..1877	CDD:99935
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900