DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Brd8 and Brdt

DIOPT Version :9

Sequence 1:	NP_651685.2	Gene:	Brd8 / 43460	FlyBaseID:	FBgn0039654	Length:	872	Species:	Drosophila melanogaster
Sequence 2:	XP_006534791.1	Gene:	Brdt / 114642	MGIID:	1891374	Length:	961	Species:	Mus musculus

Alignment Length:	546	Identity:	111/546 - (20%)
Similarity:	204/546 - (37%)	Gaps:	108/546 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 QKNCAMQYGNLLESVEATKRKKRSSESSAGVSSPATVETPTELLLRRLTEERQAEIKAQMRQDQE 128
            |.|...|...:|..|...|.||: :|.|........|....|...::..:.:|.| ||::.|.::
Mouse   428 QLNAVHQQLQVLSQVPLRKLKKK-NEKSKRAPKRKKVNNRDENPRKKPKQMKQKE-KAKINQPKK 490

  Fly   129 TYRRIQREIESLQSDAVTEQELQDMWLEIEK----------------EQEARRIEEMKLE----- 172
            ....::.|.|. .:..:...|.:.:.|:|.|                |...|.....::|
Mouse   491 KKPLLKSEEED-NAKPMNYDEKRQLSLDINKLPGDKLGRIVHIIQSREPSLRNSNPDEIEIDFET 554

  Fly   173 ---NRMREREQ------RKKDLASNWRNSSLAVKRSNQAADTTSVDMDVE----DINTSGNGKQQ 224
               :.:||.|:      ||:.|    :..:..|.||.:...:.. .:::|    |:|...|.:::
Mouse   555 LKASTLRELEKYVLACLRKRSL----KPQAKKVVRSKEELHSEK-KLELERRLLDVNNQLNCRKR 614

  Fly   225 TGPSPLLTSLLKSPTGNAPATPTPGGAAPAAGGTGSVARATAPTITSLLTSGPSSAVANQPVITM 289
            ....|  ..:.|.|....|..|.|.....|:|     :|.|..:.:|...||.||:
Mouse   615 QTKRP--AKVEKPPPPPPPPPPPPPPPELASG-----SRLTDSSSSSGSGSGSSSS--------- 663

  Fly   290 KSPTDAAFMSRPITGPPASEASTTPTLERSPSQAAPTLSMLLEKNMAAAKANESGSLVKPEGSGN 354
                     |...:...:|..|.:.:.:.|.|.::.:...:..| ....|.|:   |...|....
Mouse   664 ---------SSGSSSSSSSSGSASSSSDSSSSDSSDSEPEIFPK-FTGVKQND---LPPKENIKQ 715

  Fly   355 QEQGVDEATSSAA-----GTADSDEADPNEAQLL--EVFKNIDQIIDDIDIDMASVIDDEILKNV 412
            .:..|.:.||:.|     .||.......:..|:|  :|.:::....:...:....:.:..:|.:.
Mouse   716 IQSSVQDITSAEAPLAQQSTAPCGAPGKHSQQMLGCQVTQHLQATENTASVQTQPLSEYVLLGDC 780

  Fly   413 DDVVASP-----SNDKAEVIDFEDKLDA---LKREQSKSSPASDKPKSVELVIGSSDDSNDNIPL 469
            ..|:..|     |.:...|::.|....|   :|.:.:.|..:..||.....|:.|||:..:....
Mouse   781 KRVLLGPPVVHTSAESLTVLEPECHAPAQKDIKIKNADSWKSLGKPVKASSVLKSSDELFNQFRK 845

  Fly   470 AAVASQESKDRGQSGGESTRGTEDAESEPLTSEVAVEEIGETITIISTSSEDTAGSPPTKMEEDG 534
            ||: .:|.|.|.|.  :..:..|....:|..|:....|.|..:|:.|.||         |:::
Mouse   846 AAI-EKEVKARTQE--QMRKHLEHNAKDPKVSQENQREPGSGLTLESLSS---------KVQD-- 896

  Fly   535 ATDSLPKKEDAAEDKSEQESSSQGQN 560
                    :...||:|||:..|:.|:
Mouse   897 --------KSLEEDQSEQQPPSEAQD 914

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Brd8	NP_651685.2	PaaSYMP	<105..188	CDD:291408	21/112 (19%)
		PHA03249	402..>582	CDD:223023	38/167 (23%)
		Bromo_brd8_like	729..833	CDD:99939
Brdt	XP_006534791.1	Bromo_Brdt_I_like	26..132	CDD:99929
		Bromo_Brdt_II_like	271..372	CDD:99930
		BET	505..567	CDD:374956	10/61 (16%)
		BRD4_CDT	919..961	CDD:374989
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810