DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Brd8 and BAZ2A

DIOPT Version :9

Sequence 1:	NP_651685.2	Gene:	Brd8 / 43460	FlyBaseID:	FBgn0039654	Length:	872	Species:	Drosophila melanogaster
Sequence 2:	XP_011536103.1	Gene:	BAZ2A / 11176	HGNCID:	962	Length:	1912	Species:	Homo sapiens

Alignment Length:	857	Identity:	169/857 - (19%)
Similarity:	303/857 - (35%)	Gaps:	252/857 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 DWFSQKNC--AMQYGNL--------LESVEATKRKKRSSESS---------AGVSSPATVETPTE 105
            |:|.:::.  .:|:..|        ::::...:.:.|::|.:         .|...|..|:. ||
Human   620 DFFEERDTPEGLQWVQLSAEEIPSRIQAITGKRGRPRNTEKAKTKEVPKVKRGRGRPPKVKI-TE 683

  Fly   106 LL-------LRR------LTEERQAEI---KAQMRQDQETYRRIQR-EIE-SLQSDAVTEQELQD 152
            ||       |::      |.||.:|:|   |.:|||      ::|| |.: ::|..|..:::.:.
Human   684 LLNKTDNRPLKKLEAQETLNEEDKAKIAKSKKKMRQ------KVQRGECQTTIQGQARNKRKQET 742

  Fly   153 MWL---EIEKEQEARRIEEMKLENRMRE--REQRKKDLASNWRNSSLAVKRSNQAADTTSVDMDV 212
            ..|   |.:|:.:|.:.:....:.:::|  :.::|:.:....:......|.:.:|..|.:....:
Human   743 KSLKQKEAKKKSKAEKEKGKTKQEKLKEKVKREKKEKVKMKEKEEVTKAKPACKADKTLATQRRL 807

  Fly   213 EDINTSGNGKQQTGPSPLLTSLLKSPTGNAPAT---PTPGGAAPAAGGTGSVARATAPTITSLLT 274
            |:     ..:||     ::...:|.||.:...|   |.|           ..:|....|:
Human   808 EE-----RQRQQ-----MILEEMKKPTEDMCLTDHQPLP-----------DFSRVPGLTL----- 846

  Fly   275 SGPSSAVANQPVITMKSPTDAAFMSRPITGPPASEASTTPTLERSPSQAAPTLSMLLEKNMAAAK 339
              ||.|.::       ..|...|:.           |....|...|::..|:|.:|.|
Human   847 --PSGAFSD-------CLTIVEFLH-----------SFGKVLGFDPAKDVPSLGVLQE------- 884

  Fly   340 ANESGSLVKPEGSGNQEQGVDEATSSAAGTADSDEADPNEAQLLEVFKNIDQIIDDIDIDMASVI 404
                |.|.:.:..|.    |.:........|..|...|:..|.|::   :.:.:.:|.:...:|
Human   885 ----GLLCQGDSLGE----VQDLLVRLLKAALHDPGFPSYCQSLKI---LGEKVSEIPLTRDNV- 937

  Fly   405 DDEILK------NVDDVV----------ASPSNDKAEVIDFEDKLDALKREQSKSSPASDKPKSV 453
             .|||:      .|:..:          |.|...||.|:.|      |..|.:.|:
Human   938 -SEILRCFLMAYGVEPALCDRLRTQPFQAQPPQQKAAVLAF------LVHELNGST--------- 986

  Fly   454 ELVIGSSDDSNDNIP------------LAAVASQESKDRGQSGGESTRGTEDAESEPLTSEVAVE 506
             |:|...|.:.:::.            |..:.:..:|..|:|..| ..|.|:......:|.:..|
Human   987 -LIINEIDKTLESMSSYRKNKWIVEGRLRRLKTVLAKRTGRSEVE-MEGPEECLGRRRSSRIMEE 1049

  Fly   507 EIGETITIISTSSEDTAGSPPTKMEEDGATD----SLPKKEDAAEDKSEQE--------SSSQ-- 557
            ..|..   .....|..|..|..:...||..|    |:|:.|...|..|:::        .|||
Human  1050 TSGME---EEEEEESIAAVPGRRGRRDGEVDATASSIPELERQIEKLSKRQLFFRKKLLHSSQML 1111

  Fly   558 -----GQNK-----------AG-----------------GSTDEPELIDHQATREAQSKSGKDTA 589
                 ||::           ||                 ..||..::..|.:...|......:.|
Human  1112 RAVSLGQDRYRRRYWVLPYLAGIFVEGTEGNLVPEEVIKKETDSLKVAAHASLNPALFSMKMELA 1176

  Fly   590 GKPVTMQEKTTTQSAP--------------VPVDLHDTDEESSSL-TDSSKHDDHPRSAKAKP-P 638
            |...|.......:..|              .||...|:::..:.| .::..|      |.|:| |
Human  1177 GSNTTASSPARARGRPRKTKPGSMQPRHLKSPVRGQDSEQPQAQLQPEAQLH------APAQPQP 1235

  Fly   639 ALKLALDDSKSELELSGTPQPPSAPARTPLLRKLPHRDRSESPMVDDDATTASDHSTARSTRRRC 703
            .|:|.|...|..||..|:|..         |.:..| |.|:|..:...:.|.|..|...|:....
Human  1236 QLQLQLQSHKGFLEQEGSPLS---------LGQSQH-DLSQSAFLSWLSQTQSHSSLLSSSVLTP 1290

  Fly   704 SSTP-VIDSIPNSPASSEHTDDRRETRAASKKLFLSIYAMLLDSKHAAPFKRPFHDEHAQRHADL 767
            .|:| .:|..|:.| ..|...|..|:....:.|:.:|.|.:  ..:|||...|...|.....:..
Human  1291 DSSPGKLDPAPSQP-PEEPEPDEAESSPDPQALWFNISAQM--PCNAAPTPPPAVSEDQPTPSPQ 1352

  Fly   768 CL---RPMDFPT 776
            .|   :||:.|:
Human  1353 QLASSKPMNRPS 1364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Brd8	NP_651685.2	PaaSYMP	<105..188	CDD:291408	24/105 (23%)
		PHA03249	402..>582	CDD:223023	49/254 (19%)
		Bromo_brd8_like	729..833	CDD:99939	12/51 (24%)
BAZ2A	XP_011536103.1	HAT_MBD	551..623	CDD:238691	1/2 (50%)
		DDT	848..913	CDD:214726	17/97 (18%)
		WHIM3	1439..1477	CDD:292248
		PHD_BAZ2A	1685..1731	CDD:277099
		Bromo_BAZ2A_B_like	1805..1901	CDD:99935
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900