DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Brd8 and BRD8

DIOPT Version :9

Sequence 1:NP_651685.2 Gene:Brd8 / 43460 FlyBaseID:FBgn0039654 Length:872 Species:Drosophila melanogaster
Sequence 2:NP_631938.2 Gene:BRD8 / 10902 HGNCID:19874 Length:1235 Species:Homo sapiens


Alignment Length:960 Identity:244/960 - (25%)
Similarity:397/960 - (41%) Gaps:221/960 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSAGVQERLQLSRMPLDTWSKREQLILASAVSCSGDQNWITVSRTLKTICGNGSSNRPADWFSQK 65
            |:.|..:...||..|.:.||.||:|.|||:|..||||||::|||.:|.....|   ||.||||||
Human     1 MATGTGKHKLLSTGPTEPWSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPG---RPPDWFSQK 62

  Fly    66 NCAMQYGNLLESVEATKRKKRSSESSAGVSSPATVETPTELLLRRLTEERQAEIKAQMRQDQETY 130
            :||.||..|||:.|..|||:.....        .|||..::::|:||.||..|:|..:::.||.|
Human    63 HCASQYSELLETTETPKRKRGEKGE--------VVETVEDVIVRKLTAERVEELKKVIKETQERY 119

  Fly   131 RRIQREIESLQSDAVTEQELQDMWLEIEKEQEARRIEEMKLENRMREREQRKKDLASNWRNSSLA 195
            ||::|:.|.:|:..: :..|.::..:|..::        |||....|.:::..|.|...|.   |
Human   120 RRLKRDAELIQAGHM-DSRLDELCNDIATKK--------KLEEEEAEVKRKATDAAYQARQ---A 172

  Fly   196 VKRSNQAADTTSV-----------DMDVEDIN-------TSG-NGKQQTGPSPLL--TSLLKSPT 239
            ||...:...|..|           |..:.|:.       ||| |..:....|..|  |.:|....
Human   173 VKTPPRRLPTVMVRSPIDSASPGGDYPLGDLTPTTMEEATSGVNESEMAVASGHLNSTGVLLEVG 237

  Fly   240 GNAP--------ATPTPGGAAPAAGGTGSVARATAPTITSLLTSGPS---------SAVANQPVI 287
            |..|        .||....|:|||.|        |||::.||.:||:         :.||::|.:
Human   238 GVLPMIHGGEIQQTPNTVAASPAASG--------APTLSRLLEAGPTQFTTPLASFTTVASEPPV 294

  Fly   288 TMKSPTDAAFMSRPITGPPASEASTTPTLERSPSQAAPTLSMLLEKNMAAAKANESGSLVKPEGS 352
            .:.              ||..|:.:..|:...|:..||:.:..:....:.|..::..:.|..|..
Human   295 KLV--------------PPPVESVSQATIVMMPALPAPSSAPAVSTTESVAPVSQPDNCVPMEAV 345

  Fly   353 GNQ------------------------EQGVDEA-TSSAAGTADSDEADPNEAQLLEVFKNIDQI 392
            |:.                        ..||.|| ..|.|.:.|..|.       |::.:.:|..
Human   346 GDPHTVTVSMDSSEISMIINSIKEECFRSGVAEAPVGSKAPSIDGKEE-------LDLAEKMDIA 403

  Fly   393 I----DDIDI----DMASVIDDEILKNVDDVVASPSNDKAEVIDFEDKLDALKREQSKSSPAS-- 447
            :    :::|.    |:.::|:|::            :|..||:|......||...:....|.|  
Human   404 VSYTGEELDFETVGDIIAIIEDKV------------DDHPEVLDVAAVEAALSFCEENDDPQSLP 456

  Fly   448 -----------DKPKSVELVIGSSDDSNDNIPLAA---VASQESKDRGQSGGESTRGTEDAESEP 498
                       |||                :||.|   ...||..|..::..:......|.. ||
Human   457 GPWEHPIQQERDKP----------------VPLPAPEMTVKQERLDFEETENKGIHELVDIR-EP 504

  Fly   499 LTSEVAVEEIGETITIISTSSEDTAG-SPPTKMEEDGATDSLPKKEDAAEDKSEQESSSQGQ--- 559
             ::|:.||. .|...:|| .:|..|| .|.|.||        |.:..:.:...|..|::.|:   
Human   505 -SAEIKVEP-AEPEPVIS-GAEIVAGVVPATSME--------PPELRSQDLDEELGSTAAGEIVE 558

  Fly   560 -NKAGGSTDEPELIDHQATREAQSKSGKDTAGKPVTMQEKTTTQSAPVPVDLHDTDEESSSLTDS 623
             :.|.|..||..|.:.:.....:|.........|:....:..||.   ..::.|:.:|.|.....
Human   559 ADVAIGKGDETPLTNVKTEASPESMLSPSHGSNPIEDPLEAETQH---KFEMSDSLKEESGTIFG 620

  Fly   624 SKHDDHPRSAKAKPPALKLA-LDDSKSELELSGTPQPPSAPARTPLLRKLPHRDRSESPMVDDDA 687
            |:..|.|...:.:....:.| |::.|.|.:..|               .|...| :|.|:.:.|.
Human   621 SQIKDAPGEDEEEDGVSEAASLEEPKEEDQGEG---------------YLSEMD-NEPPVSESDD 669

  Fly   688 TTASDHSTARSTRRRCSSTPVIDSIPNSPASSEH---TDDRRETRAAS--KKLFLSIYAMLLDSK 747
            ..:..::|.:       |..:.||||:|||||:.   ::|:...:|..  ||..:.::....:.:
Human   670 GFSIHNATLQ-------SHTLADSIPSSPASSQFSVCSEDQEAIQAQKIWKKAIMLVWRAAANHR 727

  Fly   748 HAAPFKRPFHDEHAQRHADLCLRPMDFPTIKRNIDSGFIRSLSELHRDVLLMAHN-VLVAYKPHT 811
            :|..|.:|..|:.|..:..:..||||..|||:||::|.|||.:|..||::||..| |:.....|.
Human   728 YANVFLQPVTDDIAPGYHSIVQRPMDLSTIKKNIENGLIRSTAEFQRDIMLMFQNAVMYNSSDHD 792

  Fly   812 AQHKTARLFVQDCQAIKEF--SQL--PDVQAGITATPVSNTGSLRADKSS 857
            ..|....:.....:.|::|  :||  ...::||:|..:....|.|...:|
Human   793 VYHMAVEMQRDVLEQIQQFLATQLIMQTSESGISAKSLRGRDSTRKQDAS 842

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Brd8NP_651685.2 PaaSYMP <105..188 CDD:291408 23/82 (28%)
PHA03249 402..>582 CDD:223023 44/200 (22%)
Bromo_brd8_like 729..833 CDD:99939 32/108 (30%)
BRD8NP_631938.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 186..205 2/18 (11%)
termin_org_DnaJ <302..>681 CDD:274808 86/451 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 551..597 8/45 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 621..672 13/66 (20%)
Bromo_brd8_like 709..812 CDD:99939 30/102 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 827..848 4/16 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 903..940
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 966..999
Bromo_brd8_like 1105..1208 CDD:99939
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165159197
Domainoid 1 1.000 146 1.000 Domainoid score I4578
eggNOG 1 0.900 - - E1_COG5076
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 194 1.000 Inparanoid score I3837
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG46231
OrthoDB 1 1.010 - - D1509761at2759
OrthoFinder 1 1.000 - - FOG0004061
OrthoInspector 1 1.000 - - oto89471
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR15398
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X5075
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1110.960

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