DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Brd8 and cecr2

DIOPT Version :9

Sequence 1:	NP_651685.2	Gene:	Brd8 / 43460	FlyBaseID:	FBgn0039654	Length:	872	Species:	Drosophila melanogaster
Sequence 2:	XP_031754453.1	Gene:	cecr2 / 100486642	XenbaseID:	XB-GENE-6461178	Length:	1235	Species:	Xenopus tropicalis

Alignment Length:	859	Identity:	151/859 - (17%)
Similarity:	233/859 - (27%)	Gaps:	315/859 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 KNCAMQYGNLLESVEATKRKKRSSESSAGVSSPATVETPTELLLRRLTEERQAEIKAQMRQDQET 129
            ||||...|...|..|.....:|..:.:               :|:.|.|:..
Frog   471 KNCAKYNGQDSEYTEMADNLERCFKKA---------------MLKHLPEDEG------------- 507

  Fly   130 YRRIQREIESLQSDAVTEQELQDMWLEIEKEQEARRIEEMKLENRMREREQRKKDLASNWRNSSL 194
                       :||..|       |:.:|::           |..::.:...::.....|:.|..
Frog   508 -----------ESDGET-------WIHVEEK-----------ERPLKRKSLGRRSKVGGWQKSRD 543

  Fly   195 AVKRSNQAADTTSVDMDVEDINTSGNGKQQTGPSPLLTSLLKSPTGNAPATPTP-----GGAA-- 252
            ..:|..|:::::...........|   ::..||.             |.|:|.|     ||.|
Frog   544 DSERKRQSSESSRASPSTPRQEES---ERHYGPP-------------AMASPYPHQLHYGGMARQ 592

  Fly   253 -------PAAGGTGSVARATAPTITSLLTSGPSSAVANQPVITMKSPTDAAFMSRPITGPPASEA 310
                   |:|.|..:..|::.|        |.|......|...:..|.......|....|...||
Frog   593 SLHPRDMPSAPGMQAPLRSSEP--------GLSYGALRFPEPQLGDPVQQTQSYRTQASPDVPEA 649

  Fly   311 STT--------------PTLER--SPSQAAPTLSMLLEKNMAAAKANESG---SLVKPEGSGNQE 356
            |.:              |...|  .|||....|....:..|........|   ..|.|:|.|:..
Frog   650 SDSNPANFRHSRGPHVPPNSARMSGPSQEGGRLYPQAQYPMGYMPQMRPGLPDGRVPPQGPGSAP 714

  Fly   357 QGVDEATSSAAGTADSDEADPNEAQLLEVFKNIDQIIDDIDIDMASVIDDEILKNVDDV------ 415
            ..:.:.:::..|..      |...|                 ...:.:|..:::..|.|
Frog   715 FQLGQPSAAWNGNC------PPRPQ-----------------QYGAPMDPRMVRPPDSVCNGRNT 756

  Fly   416 VASPSN---DKAEVIDFEDKLDALKREQSKSSPASDKPKSVELVIGSSDDSNDNIPLAAVASQES 477
            ..|..|   |..|::       |::|..|.|.|.|   .:..|.:|.:...    |..|..:...
Frog   757 FGSAGNSMMDSPEMV-------AMQRLSSLSGPPS---SAYPLPLGPAPYP----PSGAPGTMNG 807

  Fly   478 KDRGQSGG---ESTRGTEDAESEPLTSEVAVEEIGETITIISTSSEDTAGSPPTKMEEDGATDSL 539
            .|..|...   ..|....|..|.|                    .:....||||     ..|.:|
Frog   808 PDMCQPSAVNRAKTTAPGDKASSP--------------------GDSKPKSPPT-----APTQAL 847

  Fly   540 PKKEDAAEDKSEQESSSQG---------QNK----AGGSTDEPELIDHQATREA--------QSK 583
            ...:|......:....:||         |.|    .||:.|......||....|        |||
Frog   848 MNGDDGPSPLPQVPPPNQGNPGVGAFRDQEKQWGPTGGTQDGASSAPHQGPNNAVEGTAEVGQSK 912

  Fly   584 SGKDTAGK--PVTMQEKTTTQSAPVPVDLHDTDEESSSLTDSSKHDDHPRSAKAKPPALKLALDD 646
            .....|.|  |:|...|...:..|..    :|....::|..::.|:    ....:||...    .
Frog   913 ESLKEAPKSEPITAPRKDVARPQPGA----ETVSNLATLLSTASHN----PGVVRPPGAY----P 965

  Fly   647 SKSELELSGTPQPPSAPARTPLLRKLPHRDRS------------------ESPMVDDDATTASDH 693
            |....:..|...|..||...|   :.||:|.|                  :.|....:.|.....
Frog   966 SPFPPQRYGNGHPQIAPGSYP---RYPHQDPSYPYQRHPQQGHPPYQPYQQPPYYPREYTRWPQP 1027

  Fly   694 STARST---------------RRRCSSTPVIDSIP-----NSPASSEHTDDRRE---TRAASKKL 735
            ...|.|               .|....:|:::..|     .:...:|....|.|   .|..|.|.
Frog  1028 PQQRGTYPHPGPPQNLQGMGELRSLLMSPLLEGEPKAVPGEAKVQAEEEGQRSEGGSDRPESPKQ 1092

  Fly   736 FLSIYAMLLDS-----------------------------------KH--------AAPFKRPFH 757
            ||.     |||                                   :|        ..|...|.|
Frog  1093 FLD-----LDSHKRQCGSFGYEGPQPWGNGNFRPHPNVMPQPPYPPQHHYRPQGYPQPPMHAPRH 1152

  Fly   758 DEHAQRHADLCLRP 771
            ..||:.:....|||
Frog  1153 PGHAETNGHAALRP 1166

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Brd8	NP_651685.2	PaaSYMP	<105..188	CDD:291408	9/82 (11%)
		PHA03249	402..>582	CDD:223023	40/212 (19%)
		Bromo_brd8_like	729..833	CDD:99939	17/86 (20%)
cecr2	XP_031754453.1	DDT	6..61	CDD:397084
		Bromo_gcn5_like	401..501	CDD:99941	9/44 (20%)
		PHA03247	<624..1071	CDD:223021	93/523 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910