DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14515 and REELD1

DIOPT Version :9

Sequence 1:	NP_651681.2	Gene:	CG14515 / 43454	FlyBaseID:	FBgn0039648	Length:	168	Species:	Drosophila melanogaster
Sequence 2:	NP_001341560.1	Gene:	REELD1 / 345051	HGNCID:	53638	Length:	526	Species:	Homo sapiens

Alignment Length:	161	Identity:	48/161 - (29%)
Similarity:	73/161 - (45%)	Gaps:	15/161 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLLIGAAVAFPDGAPADTCVKQRANQPNHGKARSQPAHSNPYEVVADAQ--TYHPGQQISVVIYP 75
            |.|...:.||..||....|...   ||.|  .::||.|.:.:.:.....  :|.||.:|.|.:..
Human    15 LCLASCSSAFSHGASTVACDDM---QPKH--IQAQPQHQDSHHITIHTHRTSYAPGDKIPVTVRS 74

  Fly    76 HSDQSTVFRGFFLQARDANSNEWIGEWV----QSENTKTIPECSAITHSDNRDKLGAKLIWKAPQ 136
            ..|    |.||.||||..:.::..|.:|    .|:......|..|:||||...|.....:||||.
Human    75 SRD----FMGFLLQARRVSDHQIAGTFVLIPPHSKLMTCFQEADAVTHSDKSLKRNLSFVWKAPA 135

  Fly   137 NKRGQVYFTGTVLQEYGTFWSDIVNKVQAER 167
            ...|.:.|..:|:|.|..:|:.|.:.|.:::
Human   136 QPVGDIKFLLSVVQSYFVYWARIESSVVSQQ 166

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14515	NP_651681.2	Reeler	30..163	CDD:260081	41/138 (30%)
REELD1	NP_001341560.1	Reeler	33..155	CDD:366876	39/130 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	242..272
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..336
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	370..398
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141362
Domainoid	1	1.000	65	1.000	Domainoid score	I10072
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0009692
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_111875
Panther	1	1.100	-	-	O	PTHR45828
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.840