Protein Alignment CG11898 and ABCC12

DIOPT Version :10

• Sequence 1: NP_651679.2
• Gene: CG11898 / 43451
• FlyBaseID: FBgn0039645
• Length: 1320
• Species: Drosophila melanogaster
• Sequence 2: NP_150229.2
• Gene: ABCC12 / 94160
• HGNCID: 14640
• Length: 1359
• Species: Homo sapiens
• Alignment Length: 1367
• Identity: 423/1367 - (30%)
• Similarity: 678/1367 - (49%)
• Gaps: 180/1367 - (13%)

  Fly    10 PNPVTKANFFSKWFFIWTREILVKGLQR-----NLDPSDLYETEPSLESTQVSSFLLGHWEQELK 69
            ||||..|...|...|.|...::|||.::     .|.|...|::    ..|....|.: .|::|:.
Human    43 PNPVDDAGLLSFATFSWLTPVMVKGYRQRLTVDTLPPLSTYDS----SDTNAKRFRV-LWDEEVA 102

  Fly    70 RSKPNVLRMIFKAYGWSF----VPASIVYSIMAIAVHTTQPLMLGGLVSFFSEST-GKITKHSAY 129
            |..|.  :.......|.|    |...||.:|:.|.:....|::|...:...:|.| ||:.
Human   103 RVGPE--KASLSHVVWKFQRTRVLMDIVANILCIIMAAIGPVILIHQILQQTERTSGKVW----- 160

  Fly   130 LYAMGVVLCSLISGLFFHPFMKYLF---------RVGSRVRLACAGLVYRKFL------RVSVAA 179
               :|:.||   ..||...|.|..|         |...|:::|.:.||:...:      .:||
Human   161 ---VGIGLC---IALFATEFTKVFFWALAWAINYRTAIRLKVALSTLVFENLVSFKTLTHISV-- 217

  Fly   180 DNSGVSGYAISLMATD-LPTFNESFYCFHELWRGPLEGVVFVYII------YQLIGWPAVVGLGT 237
                  |..::::::| ...|..:.:|       ||...:.:.::      :.::|..|::|:..
Human   218 ------GEVLNILSSDSYSLFEAALFC-------PLPATIPILMVFCAAYAFFILGPTALIGISV 269

  Fly   238 IVAFIPLQAWAARAIARYKRSSADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMD 302
            .|.|||:|.:.|:..:.::||:..|.|:||:.|||.:..::|||||||||||...|..:|:.|..
Human   270 YVIFIPVQMFMAKLNSAFRRSAILVTDKRVQTMNEFLTCIRLIKMYAWEKSFTNTIQDIRRRERK 334

  Fly   303 SIRGSTYIYAGLQCTG-MISKLSLFLSLVTYVFTGDIVTSQKVFIVASYYDHLNDSLLHSWPLAI 366
            .:..:.::.:|..... ::|.:::.|:|..::.....:|:...|.|.:.::.:..|:. ..|.:|
Human   335 LLEKAGFVQSGNSALAPIVSTIAIVLTLSCHILLRRKLTAPVAFSVIAMFNVMKFSIA-ILPFSI 398

  Fly   367 NMWVETFVVANRVKDFLFQHENPADGGVHNFKEAEDNPEHGNFFGRTHKPKAEVKSITVHKLSAS 431
            ....|..|...|:|..|.....|      ::....::|:       |....|.......|:.|..
Human   399 KAMAEANVSLRRMKKILIDKSPP------SYITQPEDPD-------TVLLLANATLTWEHEASRK 450

  Fly   432 WDQKKQEKRHRH---------------------------------IEDVSFQAQDQQFVGIVGTV 463
            ...||.:.:.||                                 :..:||..:..:.:||.|.|
Human   451 STPKKLQNQKRHLCKKQRSEAYSERSPPAKGATGPEEQSDSLKSVLHSISFVVRKGKILGICGNV 515

  Fly   464 GAGKSTLLQVILGELDIISGSVEVNGVLSYAPQEPWLLRGSLRDNILFTEPYDEQRYLEVLRVCH 528
            |:|||:||..:||::.:..|.|.|||.|:|..|:.|:..|::|:||||.|.||.|||...:|||.
Human   516 GSGKSSLLAALLGQMQLQKGVVAVNGTLAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCG 580

  Fly   529 LDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLARAVYRKADIYLLDDPLSAVDSHVSKMLLDRC 593
            |.:|:..||.||.|.:||.|.:|||||:.|:|||||||....:|||||||||||:||.|.:.:.|
Human   581 LQKDLSNLPYGDLTEIGERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEEC 645

  Fly   594 LNEFLSKKIRILVTHRVQLLRHVDHLVLLEGGRISVQGHYDAL-------KKLIR---------- 641
            :.:.|..|..:||||::|.|...|.::|||.|.|..:|.:..|       .|||.
Human   646 IKKTLRGKTVVLVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDP 710

  Fly   642 -----------FRMSVANDVEVAKLRAMRTDSVYEEPEPRKSLSQEEHMDRHEIEQQF--KEQQQ 693
                       |:.|.|...|.|.:..:...:  |:.|.::|.:..|.:|....|.|.  .|..|
Human   711 EHLYNAAMVEAFKESPAEREEDAGIIVLAPGN--EKDEGKESETGSEFVDTKVPEHQLIQTESPQ 773

  Fly   694 IGSVKLQTYKEYFKVLGHPLVVVLILLMFVVARSSEATMDIFLSKWATWEETEPNQHEPIPEYHR 758
            .|:|..:||..|.|..|..|:.:..:.:|::...|.|..:.:|..|.    .:.::....|:.:|
Human   774 EGTVTWKTYHTYIKASGGYLLSLFTVFLFLLMIGSAAFSNWWLGLWL----DKGSRMTCGPQGNR 834

  Fly   759 TRLRM------------MILYTFLILCTLIFYVLRTFGFFMMTLRISLRIHDQLFQGVIRAFMHF 811
            |...:            ..:||..::..|:|.|.:.|.|...||..|..:||.:|..::::.|.|
Human   835 TMCEVGAVLADIGQHVYQWVYTASMVFMLVFGVTKGFVFTKTTLMASSSLHDTVFDKILKSPMSF 899

  Fly   812 FTLATSGRILNRFSSDVLAIDVNLP---QAMMDSIEFAVNALAVLAVVSTANIWLLIPATVVVAL 873
            |....:||::||||.|:..:||.||   :..:......|..|.:||.|..|  .||:.|::.|..
Human   900 FDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFMVVFILVILAAVFPA--VLLVVASLAVGF 962

  Fly   874 LYGCRCLYIGASRSLKRIETISRSPIYSHTNATFKGLATIRALNGTKYMERDFHYYQNENTSALY 938
            ....|..:.|. :.||::|.:||||.::|..::.:||..|.|. |.|.....:|        .||
Human   963 FILLRIFHRGV-QELKKVENVSRSPWFTHITSSMQGLGIIHAY-GKKESCITYH--------LLY 1017

  Fly   939 LHVSINRAFAFWTDLICVLYILAVTFSFLLFDKHRGYYSGDVGLAITQSMKLVLMCQAGMRQTVE 1003
            .:.:: |.||...|::  :.||..|.:.|:........:...||:::..::|..:.|..:|...|
Human  1018 FNCAL-RWFALRMDVL--MNILTFTVALLVTLSFSSISTSSKGLSLSYIIQLSGLLQVCVRTGTE 1079

  Fly  1004 LENMMTSVERVMEYVNIPSEPAYETEESVNLPKHWPSGGQLDFRDLRLRYSNHGPYILKGLTFTI 1068
            .:...||||.:.||::..........:....||.|||.|::.|||.::||.::.|.:|..|...|
Human  1080 TQAKFTSVELLREYISTCVPECTHPLKVGTCPKDWPSRGEITFRDYQMRYRDNTPLVLDSLNLNI 1144

  Fly  1069 RGEEKIGIVGHTAAGKSSIVHALFRLAH-INGHISIDGFETSQLGLHDLRRRISIIPQDPVLFSG 1132
            :..:.:||||.|.:||||:..|||||.. .:|.|.||..:...|.|.|||.::::||||||||.|
Human  1145 QSGQTVGIVGRTGSGKSSLGMALFRLVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVG 1209

  Fly  1133 SLRFNLDPFEEKTDEELWLALEAVKLKEFVSNLKDGINCRLHDCGANFSMGQRQLVCLARALLRQ 1197
            ::|:||||||..|||.||..||...:::.:..|.:.:...:.:.|.|||:|:|||:|:||||||.
Human  1210 TVRYNLDPFESHTDEMLWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRN 1274

  Fly  1198 NKILIMDEATANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGRVVELGHPH 1262
            :||:::|||||::|.:||.|:|..|...|..||||||||||:||::.|.|:|::.|:|:|...|.
Human  1275 SKIILLDEATASMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPE 1339

  Fly  1263 EL 1264
            .|
Human  1340 VL 1341

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	MRP_assoc_pro	2..1268	CDD:188098	423/1367 (31%)
ABCC12	NP_150229.2	MRP_assoc_pro	43..1344	CDD:188098	423/1367 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	446..491		5/44 (11%)