DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and ABCC3

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_003777.2	Gene:	ABCC3 / 8714	HGNCID:	54	Length:	1527	Species:	Homo sapiens

Alignment Length:	1394	Identity:	436/1394 - (31%)
Similarity:	695/1394 - (49%)	Gaps:	179/1394 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SAVHEQRQPNPVTKANFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLGHWEQ 66
            ||.:....|.|.|.|.|.|:.||.|..::.:.|.:..|:..||:..:....|..|...||..|.:
Human   198 SAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEAWRK 262

  Fly    67 ELKRS----------------------------KPNVLRMIFKAYGWSFVPASIVYSIMAIAVHT 103
            :.|::                            ||:.|:.:...:|.||: .|..:.::...:..
Human   263 QEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFL-ISACFKLIQDLLSF 326

  Fly   104 TQPLMLGGLVSFFSESTGKITKHSAYLYAMGVVLCSLISGLFFHPFMKYLFRVGSRVRLACAGLV 168
            ..|.:|..|:.|.|....  .....:|.|..:.|||::..|....:..|:|..|.:.|....|::
Human   327 INPQLLSILIRFISNPMA--PSWWGFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVI 389

  Fly   169 YRKFLRVSVAADNSGVSGYAISLMATDLPTFNESFYCFHELWRGPLEGVVFVYIIYQLIGWPAVV 233
            |||.|.::.:...:...|..::||:.|...|.:.....:.||..||:.::.:|.::|.:|...:.
Human   390 YRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLA 454

  Fly   234 GLGTIVAFIPLQAWAARAIARYKRSSADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRK 298
            |:..:|..|||....|..:..::.....:.|.|:|||:||:..::::|:||||.||.|.:..:|:
Human   455 GVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQ 519

  Fly   299 EEMDSIRGSTYIYAGLQCTGMISKLSLFLSLVT-----YVFTGDIVTSQKVFIVASYYDHLNDSL 358
            .|:..:|.:.|::.....|.|.|  ...::|:|     ||...:::.::|.|:..|.::.|. ..
Human   520 GELQLLRTAAYLHTTTTFTWMCS--PFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILR-LP 581

  Fly   359 LHSWPLAINMWVETFVVANRVKDFLFQHE-NPADGGVHNFKEAEDNPEHGNFFGRTHKPKAEVKS 422
            |:..|..|:...:..|...|::.||.|.| :|     .:.:....:|.:               :
Human   582 LNMLPQLISNLTQASVSLKRIQQFLSQEELDP-----QSVERKTISPGY---------------A 626

  Fly   423 ITVHKLSASWDQKKQEKRHRHIEDVSFQAQDQQFVGIVGTVGAGKSTLLQVILGELDIISGSVEV 487
            ||:|..:.:|.|......|    .:..|......|.:||.||.|||:|:..:|||::.:.|.|.:
Human   627 ITIHSGTFTWAQDLPPTLH----SLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHM 687

  Fly   488 NGVLSYAPQEPWLLRGSLRDNILFTEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLS 552
            .|.::|.||:.|:...:|::|:||.:..:.:||.:.|..|.|..|:|.||.||.|.:||.|.:||
Human   688 KGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLS 752

  Fly   553 GGQKARVSLARAVYRKADIYLLDDPLSAVDSHVSKMLLDRCLNE--FLSKKIRILVTHRVQLLRH 615
            |||:.|||||||||..|||:|||||||||||||:|.:.|..:..  .|:.|.|:||||.:..|..
Human   753 GGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQ 817

  Fly   616 VDHLVLLEGGRISVQGHYDAL-----------------------------------KKLIRFRMS 645
            .|.:::|..|::|..|.|.||                                   |:.:....:
Human   818 TDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDT 882

  Fly   646 VANDVEVA---------------KLRAMRTDSVYE-EPEPRKSLSQEEHMDRHEIEQQ----FKE 690
            ::|..::.               :|.|:.:|...: .|.||:.|...|.:...|.:..    .:|
Human   883 LSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEE 947

  Fly   691 QQQIGSVKLQTYKEYFKVLGHPLVVVLILLMFVVARSSEAT-MDIFLSKWATWEETEPNQHEPIP 754
            :..||:|:|..:.:|.|.:|  |...|.:.:..|.:|:.|. .:::||.|......:..|
Human   948 KAAIGTVELSVFWDYAKAVG--LCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQ----- 1005

  Fly   755 EYHRTRLRMMILYTFLILCTLIFYVLRTFGFFMMTLRISLR---------IHDQLFQGVIRAFMH 810
              :.|.||:.:.....||          .||.:|...:::.         :|..|....||:...
Human  1006 --NNTSLRLGVYAALGIL----------QGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQS 1058

  Fly   811 FFTLATSGRILNRFSSDVLAIDVNLPQAMMDSIEFAVNALAVLAVVSTAN---IWLLIPATVVVA 872
            ||....||||||.||.|:..:|..|...::..:....||::.|.|:..:.   ..:::|..|:..
Human  1059 FFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYT 1123

  Fly   873 LLYGCRCLYIGASRSLKRIETISRSPIYSHTNATFKGLATIRALNGTKYMERDFHYYQ----NEN 933
            |:   :..|...||.|||:|::||||||||.:.|..|.:.|||.|    ..|||....    :.|
Human  1124 LV---QRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYN----RSRDFEIISDTKVDAN 1181

  Fly   934 TSALYLHVSINRAFAFWTDLI--CVLYILAVTFSFLLFDKHRGYYS---GDVGLAITQSMKLVLM 993
            ..:.|.::..||..:...:.:  ||: :.|..|:.:      |..|   |.|||:::.|:::...
Human  1182 QRSCYPYIISNRWLSIGVEFVGNCVV-LFAALFAVI------GRSSLNPGLVGLSVSYSLQVTFA 1239

  Fly   994 CQAGMRQTVELENMMTSVERVMEYVNIPSEPAYETEESVNLPKHWPSGGQLDFRDLRLRYSNHGP 1058
            ....:|...:||:.:.:||||.||....:|..:..|.| ..|:.||..|:::||:..:||.....
Human  1240 LNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGS-RPPEGWPPRGEVEFRNYSVRYRPGLD 1303

  Fly  1059 YILKGLTFTIRGEEKIGIVGHTAAGKSSIVHALFR-LAHINGHISIDGFETSQLGLHDLRRRISI 1122
            .:|:.|:..:.|.||:||||.|.|||||:...||| |....|.|.|||...:.:||||||.:::|
Human  1304 LVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTI 1368

  Fly  1123 IPQDPVLFSGSLRFNLDPFEEKTDEELWLALEAVKLKEFVSNLKDGINCRLHDCGANFSMGQRQL 1187
            |||||:||||:||.|||||...::|::|.|||...|..|||:...|::.:..:.|.|.|:|||||
Human  1369 IPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQL 1433

  Fly  1188 VCLARALLRQNKILIMDEATANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDM 1252
            |||||||||:::||::|||||.:|.|||||||..|.|:|..||||||||||:|:||..||:|:|.
Human  1434 VCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDK 1498

  Fly  1253 GRVVELGHPHELLHNRHGYLHRFVEKTGV 1281
            |.|.|...|..|:..| |..:......|:
Human  1499 GVVAEFDSPANLIAAR-GIFYGMARDAGL 1526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	431/1372 (31%)
		ABC_membrane	92..358	CDD:294371	68/270 (25%)
		ABCC_MRP_domain1	423..626	CDD:213217	87/204 (43%)
		ABC_membrane	762..988	CDD:294371	68/246 (28%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	117/219 (53%)
ABCC3	NP_003777.2	SunT	7..1526	CDD:331423	435/1392 (31%)
ABCC3	NP_003777.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	910..932		6/21 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151510
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.650