Protein Alignment CG11898 and YBT1

DIOPT Version :9

• Sequence 1: NP_651679.2
• Gene: CG11898 / 43451
• FlyBaseID: FBgn0039645
• Length: 1320
• Species: Drosophila melanogaster
• Sequence 2: NP_013052.1
• Gene: YBT1 / 850678
• SGDID: S000003971
• Length: 1661
• Species: Saccharomyces cerevisiae
• Alignment Length: 1469
• Identity: 433/1469 - (29%)
• Similarity: 699/1469 - (47%)
• Gaps: 263/1469 - (17%)

  Fly    10 PNPVTKANFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLGHW----EQELKR 70
            |.|||....|..|  .|....:.|..:.::...|::    .|.....|.|::..:    :.::||
Yeast   280 PEPVTSIAGFICW--AWLDSFVWKAHKVSIKVKDIW----GLMMQDYSFFVVKKFRYFVDHKVKR 338

  Fly    71 SKPNVLRMIF--------KAYGWSFVPASIVYSIMAIAVHTTQPLMLGGLVSF-----------F 116
            .:...|.:.|        :.: |:|                     ||.::||           :
Yeast   339 KRIFSLNLFFFFSNYLVLQCF-WAF---------------------LGSVLSFIPTVLLKRILEY 381

  Fly   117 SESTGKITKHSAYLYA----MGVVLCSL--ISGLFFHPFMKYLFRVGSRVRLACAGLVYRKFLR- 174
            .|.......:.|:.|.    :|.:|.::  ...|||..      ||..|::......:|.|.||
Yeast   382 VEDQSSAPSNLAWFYVTVMFVGRILVAICQAQALFFGR------RVCIRMKSIIISEIYTKALRR 440

  Fly   175 --------------------VSVAADNSGVS----GYAISLMATDLPTFNESFYC--FHELWRGP 213
                                .|:..|....|    |..|:|||.|  .|..|..|  .|......
Yeast   441 KISTNKTKPSNEDPQEINDQKSINGDEESTSSANLGAIINLMAID--AFKVSEICGYLHSFLEAF 503

  Fly   214 LEGVVFVYIIYQLIGWPAVVGLGTIVAFIPLQAWAARAIARYKRSSADVGDERVKLMNEIIAAMQ 278
            :..||.:.::|:|:|:.|:||:..|||.:||....|:.|...::.:..|.|.|::.:||...|::
Yeast   504 VMTVVALALLYRLLGFAAIVGVLIIVAMLPLNYKLAKYIGDLQKKNLAVTDNRIQKLNEAFQAIR 568

  Fly   279 LIKMYAWEKSFAKLIGKVRKEEMDSIRGSTYIYAGLQCTGMISKLSLFLSLVT-----------Y 332
            :||.::||::|.|.|..:|:.|:..:...:.:::          :|.||..||           |
Yeast   569 IIKYFSWEENFEKDINTIRENELSLLLMRSIVWS----------ISSFLWFVTPTIVTAASFAYY 623

  Fly   333 VFT-GDIVTSQKVFIVASYYDHLNDSLLHSWPL-----AINMWVETFVVANRVKDFLFQHENPAD 391
            ::. |:::|:...|...|.:..|.|      ||     .::..|::.|..:||:|||.:::
Yeast   624 IYVQGEVLTTPVAFTALSLFTLLRD------PLDRLSDMLSFVVQSKVSLDRVQDFLNEND---- 678

  Fly   392 GGVHNFKEAEDNPEHGNFFGRTHKPKAEVKSITVHKLSASWDQKKQEKRHRHIEDVSFQAQDQQF 456
              ...:.:...:| :||.|.        .::.|:     |||:..|:.:   ::|::.:.:..:.
Yeast   679 --TKKYDQLTIDP-NGNRFA--------FENSTI-----SWDKDNQDFK---LKDLNIEFKTGKL 724

  Fly   457 VGIVGTVGAGKSTLLQVILGELDIISGS-------------VEVNGV---LSYAPQEPWLLRGSL 505
            ..::|..|:||::||..:|||:.:::|.             |:.||.   ::|..|..|||..::
Yeast   725 NVVIGPTGSGKTSLLMALLGEMYLLNGKVVVPALEPRQELIVDANGTTNSIAYCSQAAWLLNDTV 789

  Fly   506 RDNILFTEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLARAVYRKAD 570
            ::||||..|::|.||..|:..|.|.||.|.|..||.|.:||.|.:||||||.|||||||:|..|.
Yeast   790 KNNILFNSPFNEARYKAVVEACGLKRDFEILKAGDLTEIGEKGITLSGGQKQRVSLARALYSNAR 854

  Fly   571 IYLLDDPLSAVDSHVSKMLLDRCL-NEFLSKKIRILVTHRVQL-LRHVDHLVLLEGGRISVQGH- 632
            ..||||.|||||||.:..:.|.|: ...:..:..|||:|.:.| ||:.:.:||||.||:..||.
Yeast   855 HVLLDDCLSAVDSHTASWIYDNCITGPLMEDRTCILVSHNIALTLRNAELVVLLEDGRVKDQGDP 919

  Fly   633 YDALKK-------LIR----------FRMSVANDVEVAKLRAMRTDSV--------YEEPEPRKS 672
            .|.|:|       |::          ..::..:...::.|.|::...|        :|..:.:||
Yeast   920 IDMLQKGLFGEDELVKSSILSRANSSANLAAKSSTSLSNLPAVKEQQVSVNNNSSHFEAKKLQKS 984

  Fly   673 LSQEEHM--DRHEIEQQFKEQQQIGSVKLQTYKEYFKVLGHPLVVVLILLMFVVA---------- 725
            |..|...  |...|:::.||:   |.|.|..||.|.|:.|...:|..:..:|::|
Yeast   985 LRTEAERTEDGKLIKEETKEE---GVVGLDVYKWYLKIFGGWKIVSFLASLFLIAQLLYIGQSWW 1046

  Fly   726 ---------------RSSEATMDIFLSK-------WATWEETEPNQHEPIPEYHRTRLRMMILYT 768
                           |:..|.  .|:||       |....:......|..|....:.:..::||.
Yeast  1047 VRAWASHNVIAKIIPRAQRAI--AFISKKASHLIDWRGSSQISMASAENQPSSGHSTMYYLVLYL 1109

  Fly   769 FLILCTLIFYVLRTFGFFMMTLRISLRIHDQLFQGVIRAFMHFFTLATSGRILNRFSSDVLAIDV 833
            .:.....:....:|...|:..:..|.:|.:.:...|:.:.:.||....:|||:||||.|:.|||.
Yeast  1110 IIGFAQALLGAGKTILNFVAGINASRKIFNMILNKVLHSKIRFFDATPTGRIMNRFSKDIEAIDQ 1174

  Fly   834 NLPQAMMDSIEFAVNALAVLAVVSTANIWLLIPATVVVALLYGCRCLYIGASRSLKRIETISRSP 898
            .|...:..:....:..|:.:.:::......|..|.||..|.|.....|:..||.|||.|:|||||
Yeast  1175 ELTPYIQGAFYSLIECLSTVILITFITPQFLSVAIVVSILYYFVGYFYMAGSRELKRFESISRSP 1239

  Fly   899 IYSHTNATFKGLATIRALNGT-KYMERDFHYYQNENTSALYLHVSINRAFAFWTDLICVLYILAV 962
            ||.|.:.|..|:.||||.... ::|:.:.|.....|....||.|: ||..||..|:|..|.|...
Yeast  1240 IYQHFSETLVGVTTIRAFGDEGRFMQENLHKIDENNKPFFYLWVA-NRWLAFRIDMIGSLVIFGA 1303

  Fly   963 TFSFLLFDKHRGYYSGDVGLAITQSMKLVLMCQAGMRQTVELENMMTSVERVMEYVNIPSEPAYE 1027
            .. |:||:.: ...||..|:::|.::.........:|...|:|..|.|||||.||:.|..||..|
Yeast  1304 GL-FILFNIN-NLDSGMAGISLTYAISFTEGALWLVRLYSEVEMNMNSVERVKEYMEIEQEPYNE 1366

  Fly  1028 TEESVNLPKHWPSGGQLDFRDLRLRYSNHGPYILKGLTFTIRGEEKIGIVGHTAAGKSSIVHALF 1092
            .:|..  |..||..|:::..||.|||:.:.|.::|.::|::..:.||||||.|.||||:|:.|||
Yeast  1367 HKEIP--PPQWPQDGKIEVNDLSLRYAPNLPRVIKNVSFSVDAQSKIGIVGRTGAGKSTIITALF 1429

  Fly  1093 R-LAHINGHISIDGFETSQLGLHDLRRRISIIPQDPVLFSGSLRFNLDPFEEKTDEELWLALEAV 1156
            | |....|||.||..:.|.:.|..|||.|:||||||.||||:::.||||::|.:|.:::.||:.|
Yeast  1430 RFLEPETGHIKIDNIDISGVDLQRLRRSITIIPQDPTLFSGTIKTNLDPYDEFSDRQIFEALKRV 1494

  Fly  1157 KL----------------------KEFVSNLKDGINCRLHDCGANFSMGQRQLVCLARALLRQNK 1199
            .|                      .|.|:...| ::..:.:.|:|.|.|||||:||||:|||..|
Yeast  1495 NLISEEQLQQGATRETSNEASSTNSENVNKFLD-LSSEISEGGSNLSQGQRQLMCLARSLLRSPK 1558

  Fly  1200 ILIMDEATANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGRVVELGHPHEL 1264
            |:::|||||::|..:|..|||.|..:|...|:|||||||.:|:|.|:::|:|.|.|.|..||:.|
Yeast  1559 IILLDEATASIDYSSDAKIQETIRKEFQGSTILTIAHRLRSVIDYDKILVMDAGEVKEYDHPYSL 1623

  Fly  1265 LHNRHGYLHRFVEKTGVGTAQHLRHLAEQSYRKRVLGRK 1303
            |.|:....:...|.:  |....|..||::::.:::..:|
Yeast  1624 LLNKQSAFYSMCEHS--GELDILIELAKKAFVEKLNSKK 1660

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	426/1432 (30%)
		ABC_membrane	92..358	CDD:294371	74/321 (23%)
		ABCC_MRP_domain1	423..626	CDD:213217	84/220 (38%)
		ABC_membrane	762..988	CDD:294371	70/226 (31%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	105/241 (44%)
YBT1	NP_013052.1	MRP_assoc_pro	<353..1639	CDD:188098	412/1367 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344650
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.640