DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and ABCC11

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_001319112.1	Gene:	ABCC11 / 839922	AraportID:	AT1G30420	Length:	1495	Species:	Arabidopsis thaliana

Alignment Length:	1326	Identity:	409/1326 - (30%)
Similarity:	674/1326 - (50%)	Gaps:	118/1326 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PVTKANFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLGHWEQELKRSKPNVL 76
            |...|:.||..:|.|...::..|.::.:...|:::.:...::..:.......|.:|.:|.||.:|
plant   228 PERYASIFSGIYFSWMTPLMQLGYRKPITERDVWQLDQWDQTETLIKRFQRCWTEESRRPKPWLL 292

  Fly    77 RMIFKAYGWSFVPASIVYSIMAIAVHTTQ---PLMLGGLVSFFSES----TGKITKHSAYLYAMG 134
            |.:..:.|..|    .:..|..:....:|   |::|..::....|.    .|.:   .|:|...|
plant   293 RALNNSLGRRF----WLGGIFKVGHDLSQFVGPVILSHILQSMIEGDPAWVGYV---YAFLIFFG 350

  Fly   135 V---VLCSLISGLFFHPFMKYLFRVGSRVRLACAGLVYRKFLRVSVAADNSGVSGYAISLMATDL 196
            |   |||.       ..:.:::.|||.|:|......::.|.||::..|..:..||...:::.||.
plant   351 VTFGVLCQ-------SQYFQHVGRVGFRLRSTLVAAIFHKSLRLTNKARKNFASGKVTNMITTDA 408

  Fly   197 PTFNESFYCFHELWRGPLEGVVFVYIIYQLIGWPAVVGLGTIVAFIPLQAWAARAIARYKRSSAD 261
            ..........|.||..|...:|.:.::||.:|..::.|...:...||.|....|.:.:..:....
plant   409 NALQLIAEQLHGLWSAPFRIIVSMVLLYQQLGVASIFGSLILFLLIPFQTLIVRKMRKLTKEGLQ 473

  Fly   262 VGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIRGSTYIYAG----LQCTGMISK 322
            ..|:||.::.||:|:|.::|.|||||||...|..:|.||:...|.:..:.|.    |..|.::..
plant   474 WTDKRVGIIYEILASMDIVKCYAWEKSFESRIQGIRNEELSWFRKAQLLSAFNSFILNSTPVVVT 538

  Fly   323 LSLFLSLVTYVFTGDIVTSQKVFIVASYYDHLNDSLLHSWPLAINMWVETFVVANRVKDFLFQHE 387
            |   :|...||..|..:|..:.|...|.:..|. |.|.:.|..|:..|...|...|:::.|...|
plant   539 L---VSFGVYVLLGGDLTPARAFTSLSLFAVLR-SPLSTLPNLISQAVNANVSLQRIEELLLSEE 599

  Fly   388 NPADGGVHNFKEAEDNPEHGNFFGRTHKPKAEVKSITVHKLSASWDQKKQEKRHRHIEDVSFQAQ 452
                      :....||        ..:|.|  .:|::.....|||.|..:..   :.|::.:..
plant   600 ----------RILAQNP--------PLQPGA--PAISIKNGYFSWDSKTSKPT---LSDINLEIP 641

  Fly   453 DQQFVGIVGTVGAGKSTLLQVILGELD-IISGSVEVNGVLSYAPQEPWLLRGSLRDNILFTEPYD 516
            ....|.|||..|.||::|:..:||||. ..:.||::.|.::|.||..|:...:||:||||...::
plant   642 VGSLVAIVGGTGEGKTSLISAMLGELSHAETSSVDIRGSVAYVPQVSWIFNATLRENILFGSDFE 706

  Fly   517 EQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLARAVYRKADIYLLDDPLSAV 581
            .:||...:.|..|..|::..|..|.|.:||.|.::|||||.|||:|||||..:|||:.|||.||:
plant   707 SERYWRAIDVTALQHDLDLFPGRDRTEIGERGVNISGGQKQRVSMARAVYSNSDIYIFDDPFSAL 771

  Fly   582 DSHVSKMLLDRCLNEFLSKKIRILVTHRVQLLRHVDHLVLLEGGRISVQGHYDALKK---LIRFR 643
            |:||:..:.|.|:...|..|.|:|||:::..|..:|.::|:..|.|..:|::..|.|   |.:..
plant   772 DAHVAHQVFDSCVKHELKGKTRVLVTNQLHFLPLMDRIILVSEGMIKEEGNFAELSKSGTLFKKL 836

  Fly   644 MSVA-----------NDVEVAKLRAMRTDSVYEEPEPRKSLS--QEEHMDRHEIEQQFKEQQQIG 695
            |..|           ||..::||....|..|.|     :||.  |:....|..:.:|  |:::.|
plant   837 MENAGKMDATQEVNTNDENISKLGPTVTIDVSE-----RSLGSIQQGKWGRSMLVKQ--EERETG 894

  Fly   696 SVKLQTYKEYFKVLGHPLVVVLILLMFVVARSSEATMDIFLSKWATWEETEPNQHEPIPEYHRTR 760
            .:.......|.|.:|...||:::|:.::...........:||.|.  :::.|..:.  |.::
plant   895 IISWDVVMRYNKAVGGLWVVMILLVCYLTTEVLRVLSSTWLSIWT--DQSTPKSYS--PGFY--- 952

  Fly   761 LRMMILYTFLILCTLIFYVLRTFGFFMMTLRISLRIHDQLFQGVIRAFMHFFTLATSGRILNRFS 825
               :::|..|....:......:|.....:|..:.|:||.:...::||.|.||....:||::||||
plant   953 ---IVVYALLGFGQVAVTFTNSFWLISSSLHAAKRLHDAMLNSILRAPMLFFETNPTGRVINRFS 1014

  Fly   826 SDVLAID---VNLPQAMMDSIEFAVNALAVLAVVSTANIWLLIPATVVVALLYGCRCLYIGASRS 887
            .|:..||   .||....|:.:...::..|::.:|||.::|.::|   ::.|.|.....|...||.
plant  1015 KDIGDIDRNVANLMNMFMNQLWQLLSTFALIGIVSTISLWAIMP---LLILFYATYIYYQSTSRE 1076

  Fly   888 LKRIETISRSPIYSHTNATFKGLATIRA---------LNGTKYMERDFHYYQNENTSALYLHVSI 943
            ::|:::::|||||:.......||::|||         :|| |.|:.:..:.....:|..:|.:..
plant  1077 VRRLDSVTRSPIYALFGEALNGLSSIRAYKAYDRMAKING-KSMDNNIRFTLASTSSNRWLTIRS 1140

  Fly   944 NRAFAFWTDLICVLYILAVTFSFLLFD--KHRGYYSGDVGLAITQSMKLVLMCQAGMRQTVELEN 1006
            .       .|..|:..|..||:.|.:.  :::..::..:||.::.::.:..:....:||..:.||
plant  1141 E-------SLGGVMIWLTATFAVLRYGNAENQAVFASTMGLLLSYTLNITTLLSGVLRQASKAEN 1198

  Fly  1007 MMTSVERVMEYVNIPSEPAYETEESVNLP-KHWPSGGQLDFRDLRLRYSNHGPYILKGLTFTIRG 1070
            .:.|||||..|:::|||.....|.  |.| ..|||.|.:.|.|:.|||....|.:|.||:|.:..
plant  1199 SLNSVERVGNYIDLPSEATAIIEN--NRPVSGWPSRGSIQFEDVHLRYRPGLPPVLHGLSFFVYP 1261

  Fly  1071 EEKIGIVGHTAAGKSSIVHALFRLAHI-NGHISIDGFETSQLGLHDLRRRISIIPQDPVLFSGSL 1134
            .||:|:||.|.|||||:::||:|:..: .|.|.||.::.::.||.||||.:|||||.||||||::
plant  1262 SEKVGVVGRTGAGKSSMLNALYRIVELEKGRILIDDYDVAKFGLTDLRRVLSIIPQSPVLFSGTV 1326

  Fly  1135 RFNLDPFEEKTDEELWLALEAVKLKEFVSNLKDGINCRLHDCGANFSMGQRQLVCLARALLRQNK 1199
            |||:|||.|..|.:||.|||...:|:.:.....|::..:.:.|.|||:|||||:.|||||||::|
plant  1327 RFNIDPFSEHNDADLWEALERAHIKDVIDRNPFGLDAEVSEGGENFSVGQRQLLSLARALLRRSK 1391

  Fly  1200 ILIMDEATANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGRVVELGHPHEL 1264
            ||.:|||||:||..||:|||..|..:|..||:|.|||||:|::|.|:::|:..|:|:|...|.||
plant  1392 ILFLDEATASVDVRTDSLIQRTIREEFKSCTMLIIAHRLNTIIDCDKILVLSSGQVLEYDSPQEL 1456

  Fly  1265 LHNRHGYLHRFVEKTGVGTAQHLRHL 1290
            |........:.|..||....|:|.:|
plant  1457 LSRDTSAFFKMVHSTGPENGQYLSNL 1482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	403/1302 (31%)
		ABC_membrane	92..358	CDD:294371	71/279 (25%)
		ABCC_MRP_domain1	423..626	CDD:213217	77/203 (38%)
		ABC_membrane	762..988	CDD:294371	60/239 (25%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	109/219 (50%)
ABCC11	NP_001319112.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	179	1.000	Domainoid score	I1056
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720