DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and ABCC12

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_001319111.1	Gene:	ABCC12 / 839921	AraportID:	AT1G30410	Length:	1498	Species:	Arabidopsis thaliana

Alignment Length:	1338	Identity:	411/1338 - (30%)
Similarity:	676/1338 - (50%)	Gaps:	139/1338 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PVTKANFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLGHWEQELKRSKPNVL 76
            |...|:.||:.:|.|...::..|.::.:...|:::.:...::..:.......|.:|.:|.||.:|
plant   228 PERHASIFSRIYFGWITPLMQLGYRKPITEKDVWQLDKWDQTETLIKRFQRCWTEESRRPKPWLL 292

  Fly    77 RMIFKAYGWSFVPASIVYSIMAIAVHTTQ---PLMLGGLVSFFSESTGKITKHSAYLYA----MG 134
            |.:..:.|..|..|.| :.:..|....:|   |::|..|:....|..   .....|:||    :|
plant   293 RALNNSLGGRFWLAGI-FKVTRIGNDLSQFVGPVILSHLLRSMQEGD---PAWVGYVYAFIIFVG 353

  Fly   135 VVLCSLISGLFFHPFMKYLFRVGSRVRLACAGLVYRKFLRVSVAADNSGVSGYAISLMATDLPTF 199
            |.|..|....:|    :.::|||.|:|......::.|.||::..|..:..||...:::.||....
plant   354 VTLGVLCEAQYF----QNVWRVGFRLRSTLVAAIFHKSLRLTHEARKNFASGKVTNMITTDANAL 414

  Fly   200 NESFYCFHELWRGPLEGVVFVYIIYQLIGWPAVVGLGTIVAFIPLQAWAARAIARYKRSSADVGD 264
            .:.....|.||..|...:|.:.::||.:|..::.|...:...||||......:.:..:......|
plant   415 QQISQQLHGLWSAPFRIIVSMILLYQQLGVASLFGSLILFLLIPLQTLIISKMRKLTKEGLQWTD 479

  Fly   265 ERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIRGSTYIYAGLQCTGMISKLSLFLSL 329
            :||.:.|||:::|..:|.|||||||...|..:|.||:...|.:..:.|  ..:.:::.:.:.:::
plant   480 KRVGITNEILSSMDTVKCYAWEKSFESRIQGIRNEELSWFRKAQLLSA--FNSFILNSIPVVVTV 542

  Fly   330 VTY-VFT---GDIV-----TSQKVFIVASYYDHLNDSLLHSWPLAINMWVETFVVANRVKDFLFQ 385
            |:: ||.   ||:.     ||..:|.|..:       .|:..|..::..|...|...|:::.|..
plant   543 VSFGVFVLLGGDLTPARAFTSLSLFAVLRF-------PLNMLPNLLSQVVNANVSLQRIEELLLS 600

  Fly   386 HENPADGGVHNFKEAEDNPEHGNFFGRTHKP-KAEVKSITVHKLSASWDQKKQEKRHRHIEDVSF 449
            .|          :....||           | :....:|::.....|||.|..:..   :.|::.
plant   601 EE----------RILAQNP-----------PLQPGTPAISIKNGYFSWDSKTTKPT---LSDINL 641

  Fly   450 QAQDQQFVGIVGTVGAGKSTLLQVILGELD-IISGSVEVNGVLSYAPQEPWLLRGSLRDNILFTE 513
            :......|.|||..|.||::|:..:||||. ..:.||.:.|.::|.||..|:...::|:||||..
plant   642 EIPVGTLVAIVGGTGEGKTSLISAMLGELSHAETTSVVIRGSVAYVPQVSWIFNATVRENILFGS 706

  Fly   514 PYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLARAVYRKADIYLLDDPL 578
            .::.:||...:....|..|::.||..|.|.:||.|.::|||||.|||:|||||..:|:|:.||||
plant   707 DFESERYWRAIDATALQHDLDLLPGRDLTEIGERGVNISGGQKQRVSMARAVYSNSDVYIFDDPL 771

  Fly   579 SAVDSHVSKMLLDRCLNEFLSKKIRILVTHRVQLLRHVDHLVLLEGGRISVQGHYDALKK---LI 640
            ||:|:||:..:.|.|:.:.|..|.|:|||:::..|..:|.::|:..|.|..:|.:..|.|   |.
plant   772 SALDAHVAHQVFDSCMKDELRGKTRVLVTNQLHFLPLMDKIILVSEGMIKEEGTFVELSKSGILF 836

  Fly   641 RFRMSVA-----------NDVEVAKLRAMRTDSVYEEPEPRKSLSQEEHMDRHEIEQQFKEQQQI 694
            :..|..|           ||..:.||....|..|.|     ::|...:...|.......:|:::.
plant   837 KKLMENAGKMDATQEVNTNDENILKLGPTVTVDVSE-----RNLGSTKQGKRRRSVLIKQEERET 896

  Fly   695 GSVKLQTYKEYFKVLGHPLVVVLILLMFVVARSSEATMDIFLSKWATWEETEPNQHEPIPEYHRT 759
            |.:.......|.:.:|...||:::|..::.......:...:||.| |.:.|..|..   |.::
plant   897 GIISWNVLMRYKEAVGGLWVVMILLACYLATEVLRVSSSTWLSIW-TDQSTSKNYS---PGFY-- 955

  Fly   760 RLRMMILYTFLILCTLIFYVLRTFG---------FFMMT--LRISLRIHDQLFQGVIRAFMHFFT 813
                           ::.|.|..||         |:::|  |..:.|:||.:...::||.|.||.
plant   956 ---------------IVVYALLGFGQVAVTFTNSFWLITSSLHAARRLHDAMLSSILRAPMLFFH 1005

  Fly   814 LATSGRILNRFSSDVLAID---VNLPQAMMDSIEFAVNALAVLAVVSTANIWLLIPATVVVALLY 875
            ...:||::||||.|:..||   .||....|:.:...::..|::..|||.::|.::|   ::.|.|
plant  1006 TNPTGRVINRFSKDIGDIDRNVANLMNMFMNQLWQLLSTFALIGTVSTISLWAIMP---LLILFY 1067

  Fly   876 GCRCLYIGASRSLKRIETISRSPIYSHTNATFKGLATIRA---------LNGTKYMERDFHYYQN 931
            .....|...||.::|:::::|||||:.......||::|||         :|| |.|:.:..:...
plant  1068 AAYLYYQSTSREVRRLDSVTRSPIYAQFGEALNGLSSIRAYKAYDRMAKING-KSMDNNIRFTLA 1131

  Fly   932 ENTSALYLHVSINRAFAFWTDLICVLYILAVTFSFLL--FDKHRGYYSGDVGLAITQSMKLVLMC 994
            ..:|..:|.:.:.       .|..|:..|..||:.|.  ...::..::..:||.::.::.:..:.
plant  1132 NTSSNRWLTIRLE-------TLGGVMIWLTATFAVLQNGNTNNQAGFASTMGLLLSYTLNITSLL 1189

  Fly   995 QAGMRQTVELENMMTSVERVMEYVNIPSEPAYETEESVNLPK-HWPSGGQLDFRDLRLRYSNHGP 1058
            ...:||....||.:.|||||..|:::|||.....|.  |.|. .|||||.:.|.|:.|||....|
plant  1190 SGVLRQASRAENSLNSVERVGNYIDLPSEATDIIEN--NRPVCGWPSGGSIKFEDVHLRYRPGLP 1252

  Fly  1059 YILKGLTFTIRGEEKIGIVGHTAAGKSSIVHALFRLAHI-NGHISIDGFETSQLGLHDLRRRISI 1122
            .:|.||||.:...||:|:||.|.|||||:::||||:..: .|.|.||..:.::.||.|:||.:||
plant  1253 PVLHGLTFFVSPSEKVGVVGRTGAGKSSMLNALFRIVEVEKGRIMIDDCDVAKFGLTDVRRVLSI 1317

  Fly  1123 IPQDPVLFSGSLRFNLDPFEEKTDEELWLALEAVKLKEFVSNLKDGINCRLHDCGANFSMGQRQL 1187
            |||.||||||::|||:|||.|..|..||.||....:|:.:|....|::..:.:.|.|||:|||||
plant  1318 IPQSPVLFSGTVRFNIDPFSEHNDAGLWEALHRAHIKDVISRNPFGLDAEVCEGGENFSVGQRQL 1382

  Fly  1188 VCLARALLRQNKILIMDEATANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDM 1252
            :.|||||||::|||::|||||:||..||:|||..|..:|..||:|.|||||:|::|.|:::|:..
plant  1383 LSLARALLRRSKILVLDEATASVDVRTDSLIQRTIREEFKSCTMLVIAHRLNTIIDCDKILVLSS 1447

  Fly  1253 GRVVELGHPHELLHNRHGYLHRFVEKTGVGTAQHLRHL 1290
            |:|:|...|.|||........|.|..||...||:|.:|
plant  1448 GQVLEYDSPQELLSRDTSAFFRMVHSTGPANAQYLSNL 1485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	403/1314 (31%)
		ABC_membrane	92..358	CDD:294371	71/281 (25%)
		ABCC_MRP_domain1	423..626	CDD:213217	76/203 (37%)
		ABC_membrane	762..988	CDD:294371	63/250 (25%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	110/219 (50%)
ABCC12	NP_001319111.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	179	1.000	Domainoid score	I1056
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720