DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and ABCC1

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_001031116.1	Gene:	ABCC1 / 839920	AraportID:	AT1G30400	Length:	1622	Species:	Arabidopsis thaliana

Alignment Length:	1354	Identity:	416/1354 - (30%)
Similarity:	678/1354 - (50%)	Gaps:	155/1354 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PVTKANFFSKWFFIWTREILVKGLQRNLDPSDLY------ETEPSLESTQVSSFLLGHWEQELKR 70
            |...||.|...||.|...::..|.:|.|...|::      :||..:.|.|.|      |::||::
plant   227 PERHANLFDSIFFSWLNPLMTLGSKRPLTEKDVWHLDTWDKTETLMRSFQKS------WDKELEK 285

  Fly    71 SKPNVLRMIFKAYG--------W-------SFVPASIVYSIMAIAVHTTQPLMLGGLVSFFSEST 120
            .||.:||.:..:.|        |       .||...::..::. ::...:|..:|
plant   286 PKPWLLRALNNSLGGRFWWGGFWKIGNDCSQFVGPLLLNELLK-SMQLNEPAWIG---------- 339

  Fly   121 GKITKHSAYLYA----MGVVLCSLISGLFFHPFMKYLFRVGSRVRLACAGLVYRKFLRVSVAADN 181
                    |:||    :||||..|....:|...|    |||.|:|.|....|:||.||::.....
plant   340 --------YIYAISIFVGVVLGVLCEAQYFQNVM----RVGYRLRSALIAAVFRKSLRLTNEGRK 392

  Fly   182 SGVSGYAISLMATDLPTFNESFYCFHELWRGPLEGVVFVYIIYQLIGWPAVVGLGTIVAFIPLQA 246
            ...:|...:||.||..:..:.....|.:|..|...:|.:.::||.:|..:::|...:|...|:|.
plant   393 KFQTGKITNLMTTDAESLQQICQSLHTMWSAPFRIIVALVLLYQQLGVASIIGALFLVLMFPIQT 457

  Fly   247 WAARAIARYKRSSADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIRGSTYIY 311
            .......:..:......|:|:.||||::|||..:|.||||.||...:..||.:|:...|.:..:.
plant   458 VIISKTQKLTKEGLQRTDKRIGLMNEVLAAMDTVKCYAWENSFQSKVQTVRDDELSWFRKAQLLS 522

  Fly   312 AGLQCTGMISKLSLFLSLVTY-VFT---GDIVTSQKVFIVASYYDHLNDSLLHSWPLAINMWVET 372
            |....  :::.:.:.:::|:: ||:   ||: |..:.|...|.:..|...|. ..|..|...|..
plant   523 AFNMF--ILNSIPVLVTVVSFGVFSLLGGDL-TPARAFTSLSLFSVLRFPLF-MLPNIITQMVNA 583

  Fly   373 FVVANRVKDFLFQHENPADGGVHNFKEAEDNPEHGNFFGRTHKPKAEVK----SITVHKLSASWD 433
            .|..||:::.|...|                        |...|...::    :|::.....|||
plant   584 NVSLNRLEEVLSTEE------------------------RVLLPNPPIEPGQPAISIRNGYFSWD 624

  Fly   434 QKKQEKRHRHIEDVSFQAQDQQFVGIVGTVGAGKSTLLQVILGELDIIS-GSVEVNGVLSYAPQE 497
            .|.....   :.:::........|.:||:.|.||::|:..:||||...| .:|.:.|.::|.||.
plant   625 SKADRPT---LSNINLDIPLGSLVAVVGSTGEGKTSLISAMLGELPARSDATVTLRGSVAYVPQV 686

  Fly   498 PWLLRGSLRDNILFTEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLA 562
            .|:...::||||||..|:|:::|..|:.|..|..|:|.||.||.|.:||.|.::|||||.|||:|
plant   687 SWIFNATVRDNILFGAPFDQEKYERVIDVTALQHDLELLPGGDLTEIGERGVNISGGQKQRVSMA 751

  Fly   563 RAVYRKADIYLLDDPLSAVDSHVSKMLLDRCLNEFLSKKIRILVTHRVQLLRHVDHLVLLEGGRI 627
            ||||..:|:.:|||||||:|:||.:.:.::|:...|.:..|:|||:::..|..||.::|:..|.:
plant   752 RAVYSNSDVCILDDPLSALDAHVGQQVFEKCIKRELGQTTRVLVTNQLHFLSQVDKILLVHEGTV 816

  Fly   628 SVQGHYDAL---KKLIRFRMSVANDVEVAKLRAMRTDSVYEEPEPRKSLSQ----------EEHM 679
            ..:|.|:.|   ..|.:..|..|..||           .|.|......:.|          ..::
plant   817 KEEGTYEELCHSGPLFQRLMENAGKVE-----------DYSEENGEAEVDQTSVKPVENGNANNL 870

  Fly   680 DRHEIEQQ----------FKEQQQIGSVKLQTYKEYFKVLGHPLVVVLILLMFVVARSSEATMDI 734
            .:..||.:          .:|:::.|.|..:..:.|...||...||:::::.:|:.:....:...
plant   871 QKDGIETKNSKEGNSVLVKREERETGVVSWKVLERYQNALGGAWVVMMLVICYVLTQVFRVSSST 935

  Fly   735 FLSKWATWEETEPNQHEPIPEYHRTRLRMMILYTFLILCTLIFYVLRTFGFFMMTLRISLRIHDQ 799
            :||:|.  :...|..|.|        |...|:|..|....:...::.::...|.:|..:.::||.
plant   936 WLSEWT--DSGTPKTHGP--------LFYNIVYALLSFGQVSVTLINSYWLIMSSLYAAKKMHDA 990

  Fly   800 LFQGVIRAFMHFFTLATSGRILNRFSSDV------LAIDVNLPQAMMDSIEFAVNALAVLAVVST 858
            :...::||.|.||.....|||:|||:.|:      :|:.||:   .|.||...::.:.::.:|||
plant   991 MLGSILRAPMVFFQTNPLGRIINRFAKDMGDIDRTVAVFVNM---FMGSIAQLLSTVILIGIVST 1052

  Fly   859 ANIWLLIPATVVVALLYGCRCLYIGASRSLKRIETISRSPIYSHTNATFKGLATIRALNGTKYME 923
            .::|.::|..||   .||....|...||.:||:::.:|||:|:.......||::|||......|.
plant  1053 LSLWAIMPLLVV---FYGAYLYYQNTSREIKRMDSTTRSPVYAQFGEALNGLSSIRAYKAYDRMA 1114

  Fly   924 RDFHYYQNENTSALYLHVSINRAFAFWTDLICVLYI-LAVTFSFLLFDK--HRGYYSGDVGLAIT 985
            .......:.|.....::::.||......:::..|.: |..:.:.:...|  ::..|:..:||.::
plant  1115 EINGRSMDNNIRFTLVNMAANRWLGIRLEVLGGLMVWLTASLAVMQNGKAANQQAYASTMGLLLS 1179

  Fly   986 QSMKLVLMCQAGMRQTVELENMMTSVERVMEYVNIPSEPAYETEESVNLPKHWPSGGQLDFRDLR 1050
            .::.:.....|.:|.....||.:.|||||..|:.||||.....|.: ..|..|||.|.:.|.|:.
plant  1180 YALSITSSLTAVLRLASLAENSLNSVERVGNYIEIPSEAPLVIENN-RPPPGWPSSGSIKFEDVV 1243

  Fly  1051 LRYSNHGPYILKGLTFTIRGEEKIGIVGHTAAGKSSIVHALFRLAHI-NGHISIDGFETSQLGLH 1114
            |||....|.:|.|::|.|...:|:||||.|.|||||:::||||:..: .|.|.||..:..:.||.
plant  1244 LRYRPELPPVLHGVSFLISPMDKVGIVGRTGAGKSSLLNALFRIVELEKGRILIDECDIGRFGLM 1308

  Fly  1115 DLRRRISIIPQDPVLFSGSLRFNLDPFEEKTDEELWLALEAVKLKEFVSNLKDGINCRLHDCGAN 1179
            |||:.:.||||.||||||::|||||||.|..|.:||.:||...||:.:.....|::..:.:.|.|
plant  1309 DLRKVLGIIPQAPVLFSGTVRFNLDPFSEHNDADLWESLERAHLKDTIRRNPLGLDAEVTEAGEN 1373

  Fly  1180 FSMGQRQLVCLARALLRQNKILIMDEATANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDN 1244
            ||:|||||:.|||||||::|||::|||||.||..||.|||:.|..:|..||:|.|||||:|::|.
plant  1374 FSVGQRQLLSLARALLRRSKILVLDEATAAVDVRTDVLIQKTIREEFKSCTMLIIAHRLNTIIDC 1438

  Fly  1245 DRVMVVDMGRVVELGHPHELLHNRHGYLHRFVEKTGVGTAQHLRHLAEQSYRKR 1298
            |:|:|:|.|:|.|...|..||.|......:.|:.||...|::||.:..::.|.|
plant  1439 DKVLVLDSGKVQEFSSPENLLSNGESSFSKMVQSTGTANAEYLRSITLENKRTR 1492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	407/1322 (31%)
		ABC_membrane	92..358	CDD:294371	69/273 (25%)
		ABCC_MRP_domain1	423..626	CDD:213217	79/203 (39%)
		ABC_membrane	762..988	CDD:294371	58/234 (25%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	111/219 (51%)
ABCC1	NP_001031116.1	PLN03130	1..1622	CDD:215595	416/1354 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	179	1.000	Domainoid score	I1056
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720