DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and ABCC5

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_171908.1	Gene:	ABCC5 / 839277	AraportID:	AT1G04120	Length:	1514	Species:	Arabidopsis thaliana

Alignment Length:	1368	Identity:	422/1368 - (30%)
Similarity:	667/1368 - (48%)	Gaps:	183/1368 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PVTKANFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLGHWEQ---ELKRSKP 73
            |.:.|...|.....|...:|..|.:|.|:..|:....|...:......|..:|::   |.....|
plant   229 PYSTAGLVSLITLSWLDPLLSAGSKRPLELKDIPLLAPRDRAKSSYKVLKSNWKRCKSENPSKPP 293

  Fly    74 NVLRMIFKAYGWSFVPASIVYSIMAIAVHTTQPLMLGGLVSFFSESTG--KITKHSAYLYAMGVV 136
            ::.|.|.|:: |.....:.|::.:...|....|.    |:|:|.:..|  :|..|..|:.| |:.
plant   294 SLARAIMKSF-WKEAACNAVFAGLNTLVSYVGPY----LISYFVDYLGGKEIFPHEGYVLA-GIF 352

  Fly   137 LCS-LISGLFFHPFMKYLFRVGSRVRLACAGLVYRKFLRVSVAADNSGVSGYAISLMATDLPTFN 200
            ..| ||..:....:...:..:|..||.|...:||||.|::|..|..:..||..::.||.|:....
plant   353 FTSKLIETVTTRQWYMGVDILGMHVRSALTAMVYRKGLKLSSIAKQNHTSGEIVNYMAVDVQRIG 417

  Fly   201 ESFYCFHELWRGPLEGVVFVYIIYQLIGWPAVVGL-GTIVAF---IPLQAWAARAIARYKRSSAD 261
            :..:..|::|..|::.|:.:.|:|:.:|..||..| .||::.   |||    |:....|:.....
plant   418 DYSWYLHDIWMLPMQIVLALAILYKSVGIAAVATLVATIISILVTIPL----AKVQEDYQDKLMT 478

  Fly   262 VGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIRGSTYIYAGLQCTGMISKLSLF 326
            ..|||::..:|.:..|:::|:.|||..:...:.::|:||...:|.:.|..|.:  |.:.....:|
plant   479 AKDERMRKTSECLRNMRVLKLQAWEDRYRVRLEEMREEEYGWLRKALYSQAFV--TFIFWSSPIF 541

  Fly   327 LSLVTY---VFTGDIVTSQKVFIVASYYDHLNDSLLHSWPLAINMWVETFVVANRVKDFLFQHEN 388
            ::.||:   :|.|..:|:..|....:.:..|.:. |.::|..::|..:|.|..:|:..||.:.|.
plant   542 VAAVTFATSIFLGTQLTAGGVLSALATFRILQEP-LRNFPDLVSMMAQTKVSLDRISGFLQEEEL 605

  Fly   389 PADG------GVHNFK-EAEDNPEHGNFFGRTHKPKAEVKSITVHKLSASWDQKKQEKRHRHIED 446
            ..|.      |:.|.. |.:|    |.|.......:..:..|          |.|.||..|
plant   606 QEDATVVIPRGLSNIAIEIKD----GVFCWDPFSSRPTLSGI----------QMKVEKGMR---- 652

  Fly   447 VSFQAQDQQFVGIVGTVGAGKSTLLQVILGELDIISGSVEVNGVLSYAPQEPWLLRGSLRDNILF 511
                      |.:.||||:|||:.:..||||:..|||.|.:.|...|..|..|:..|::.:||||
plant   653 ----------VAVCGTVGSGKSSFISCILGEIPKISGEVRICGTTGYVSQSAWIQSGNIEENILF 707

  Fly   512 TEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLARAVYRKADIYLLDD 576
            ..|.::.:|..|::.|.|.:|:|....||.|.:||.|.:||||||.||.||||:|:.||||||||
plant   708 GSPMEKTKYKNVIQACSLKKDIELFSHGDQTIIGERGINLSGGQKQRVQLARALYQDADIYLLDD 772

  Fly   577 PLSAVDSHVSKMLLDRCLNEFLSKKIRILVTHRVQLLRHVDHLVLLEGGRISVQGHYDAL----- 636
            |.||:|:|....|....:...|::|..:.|||:|:.|...|.:::|:.|||...|.||.|
plant   773 PFSALDAHTGSDLFRDYILSALAEKTVVFVTHQVEFLPAADLILVLKEGRIIQSGKYDDLLQAGT 837

  Fly   637 --KKLIR-----------------------FRMSVA----------NDVE-VAK----------L 655
              |.|:.                       .|.|:.          ||:| :||          |
plant   838 DFKALVSAHHEAIEAMDIPSPSSEDSDENPIRDSLVLHNPKSDVFENDIETLAKEVQEGGSASDL 902

  Fly   656 RAMRTDSVYEEPEPRKSLSQEEHMDRHEIEQQFKEQQQIGSVKLQTYKEYFKVLGHPLVVVLILL 720
            :|::......:...:|.|.||             |::..|.|.::.|..|........::.||:|
plant   903 KAIKEKKKKAKRSRKKQLVQE-------------EERVKGKVSMKVYLSYMGAAYKGALIPLIIL 954

  Fly   721 MFVVARSSEATMDIFLSKWATW--EETEPNQHEPIPEYHRTRLRMMILYTFLILCTLIFYVLR-- 781
                |:::...:.|..:.|..|  .:||.::.:..|..      ::|:||.|...:.:|..:|
plant   955 ----AQAAFQFLQIASNWWMAWANPQTEGDESKVDPTL------LLIVYTALAFGSSVFIFVRAA 1009

  Fly   782 ---TFGFFMMTLRISLRIHDQLFQGVIRAFMHFFTLATSGRILNRFSSDVLAIDVNLPQAMMDSI 843
               |||     |..:.::...:.:.|.||.|.||....:||||||.|.|...:|:::|..:....
plant  1010 LVATFG-----LAAAQKLFLNMLRSVFRAPMSFFDSTPAGRILNRVSIDQSVVDLDIPFRLGGFA 1069

  Fly   844 EFAVNALAVLAVVS--TANIWLLIPATVVVALLYGCRCLYIGASRSLKRIETISRSPIYSHTNAT 906
            ...:....::||::  |..::||: ..|.||..: .:..|:.:||.|.||.:|.:|||......:
plant  1070 STTIQLCGIVAVMTNVTWQVFLLV-VPVAVACFW-MQKYYMASSRELVRIVSIQKSPIIHLFGES 1132

  Fly   907 FKGLATIRALNGTK-YMERDFHYYQNENTSALYLHVSINRAFAFWT----DLICVLYILAVTFSF 966
            ..|.||||.....| :::|:           |||.....|.| |.:    :.:|:...|..|..|
plant  1133 IAGAATIRGFGQEKRFIKRN-----------LYLLDCFVRPF-FCSIAAIEWLCLRMELLSTLVF 1185

  Fly   967 ------LLFDKHRGYYSGDVGLAITQSMKLVLMCQAGMRQTVELENMMTSVERVMEYVNIPSE-P 1024
                  |:...|........|||:|..:.|.......:....:|||.:.|:||:.:|..|..| |
plant  1186 AFCMVLLVSFPHGTIDPSMAGLAVTYGLNLNGRLSRWILSFCKLENKIISIERIYQYSQIVGEAP 1250

  Fly  1025 AYETEESVNLPKHWPSGGQLDFRDLRLRYSNHGPYILKGLTFTIRGEEKIGIVGHTAAGKSSIVH 1089
            |  ..|....|..||:.|.::..|:::||:.:.|.:|.|::....|.:||||||.|.:|||:::.
plant  1251 A--IIEDFRPPSSWPATGTIELVDVKVRYAENLPTVLHGVSCVFPGGKKIGIVGRTGSGKSTLIQ 1313

  Fly  1090 ALFRLAH-INGHISIDGFETSQLGLHDLRRRISIIPQDPVLFSGSLRFNLDPFEEKTDEELWLAL 1153
            |||||.. ..|.|:||..:.||:||||||.|:.||||||.||.|::|.||||.||.:|:::|.||
plant  1314 ALFRLIEPTAGKITIDNIDISQIGLHDLRSRLGIIPQDPTLFEGTIRANLDPLEEHSDDKIWEAL 1378

  Fly  1154 EAVKLKEFVSNLKDGINCRLHDCGANFSMGQRQLVCLARALLRQNKILIMDEATANVDPETDNLI 1218
            :..:|.:.|......::..:.:.|.|:|:||||||.|.||||:|.|||::|||||:||..|||||
plant  1379 DKSQLGDVVRGKDLKLDSPVLENGDNWSVGQRQLVSLGRALLKQAKILVLDEATASVDTATDNLI 1443

  Fly  1219 QEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGRVVELGHPHELLHNRHGYLHRFV-----EK 1278
            |:.|.|:|..|||.|||||:.||:|:|.|:|:..|||.|...|..||.::.....:.|     ..
plant  1444 QKIIRTEFEDCTVCTIAHRIPTVIDSDLVLVLSDGRVAEFDTPARLLEDKSSMFLKLVTEYSSRS 1508

  Fly  1279 TGV 1281
            ||:
plant  1509 TGI 1511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	419/1348 (31%)
		ABC_membrane	92..358	CDD:294371	72/275 (26%)
		ABCC_MRP_domain1	423..626	CDD:213217	80/202 (40%)
		ABC_membrane	762..988	CDD:294371	67/243 (28%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	110/219 (50%)
ABCC5	NP_171908.1	MRP_assoc_pro	229..1493	CDD:188098	419/1348 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.720