Protein Alignment CG11898 and Abcb11

DIOPT Version :9

• Sequence 1: NP_651679.2
• Gene: CG11898 / 43451
• FlyBaseID: FBgn0039645
• Length: 1320
• Species: Drosophila melanogaster
• Sequence 2: NP_113948.1
• Gene: Abcb11 / 83569
• RGDID: 619930
• Length: 1321
• Species: Rattus norvegicus
• Alignment Length: 1343
• Identity: 289/1343 - (21%)
• Similarity: 515/1343 - (38%)
• Gaps: 335/1343 - (24%)

  Fly   111 GLVSFFSESTGKITKHSAYLYAMGVVLCSLISGLFFHPFMKYLFRVGSRVRLACAGLVYRKFLRV 175
            |||...||    :.|.|. :|| ||.:..||.|.|   .::.....|:|.......:.:|:.:|:
  Rat   130 GLVDIESE----MIKFSG-IYA-GVGMTVLILGYF---QIRLWVITGARQIRRMRKIYFRRIMRM 185

  Fly   176 SVAADNSGVSGYAISLMATDLPTFNESF--------------YC-----FHELWRGPLEGVVFVY 221
            .:...:....|...|..|.|:...|::.              .|     |:..|:..|    .:.
  Rat   186 EIGWFDCTSVGELNSRFADDIEKINDAIADQLAHFLQRMSTAMCGLLLGFYRGWKLTL----VIL 246

  Fly   222 IIYQLIG-WPAVVGLGTIVAFIPLQAWAARAIARYKRSSADVGDERVKLMNEIIAAMQLIKMYAW 285
            .:..||| ..||:|| :|..|..|:      :..|.::.:        :.:|::::::.:..:..
  Rat   247 AVSPLIGIGAAVIGL-SIAKFTELE------LKAYAKAGS--------IADEVLSSIRTVAAFGG 296

  Fly   286 EKSFAKLIGKVRKEEMDSIRGSTY-IYAGLQC---TGMISKLSLFLSLVTYVFTGDIVTSQK--- 343
            |..      :|.:.|.:.:....: |:.|:..   ||.:..|..|...:.:.:...:|..::
  Rat   297 ENK------EVERYEKNLVFAQRWGIWKGMVMGFFTGYMWCLIFFCYALAFWYGSTLVLDEEEYT 355

  Fly   344 ----------VFIVASYYDHLNDSLLHSWPLAINMWVETFVVANRVKDFLFQHENPADGGVHNFK 398
                      |.:.|....|.:..|            |.|             ........:.|:
  Rat   356 PGTLVQIFLCVILAAMNIGHASSCL------------EIF-------------STGCSAATNIFQ 395

  Fly   399 EAEDNPEHGNFFGRTHKPKAEVKSITVHKLSASWDQKKQEKRHRHIEDVSFQAQDQQFVGIVGTV 463
            ..:..|......|..:|.......|..|.::..:..:...|   .::::|...:..:...:||:.
  Rat   396 TIDRQPVIDCMSGDGYKLDRIKGEIEFHNVTFHYPSRPDVK---ILDNLSMVIKPGETTALVGSS 457

  Fly   464 GAGKSTLLQVILGELDIISGSVEVNG-------------VLSYAPQEPWLLRGSLRDNILF-TEP 514
            ||||||.||:|....|...|.|.::|             .:....|||.|...::.:||.| .|.
  Rat   458 GAGKSTALQLIQRFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLFSTTIAENIRFGRED 522

  Fly   515 YDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLARAVYRKADIYLLDDPLS 579
            ...:..::..:..:....:..||....|.|||||..:|||||.||::|||:.|...|.|||...|
  Rat   523 ATMEDIVQAAKDANAYNFIMALPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATS 587

  Fly   580 AVDSHVSKMLLDRCLNEFLSKKIRILVTHRVQLLRHVDHLVLLEGGRISVQGHYDAL--KKLIRF 642
            |:|:. |:..:...||:.......|.|.||:..:|..|.::..|.|....:|.::.|  :|.:.|
  Rat   588 ALDNE-SEARVQEALNKIQHGHTIISVAHRLSTVRAADVIIGFEHGVAVERGTHEELLERKGVYF 651

  Fly   643 RMSVANDVEVAKLRAMRTDSVYEEPEPRKSLSQEEHMDRHEIEQQFKEQQQIGSVKL---QTYKE 704
            .:.....         :.|:.::|    .|:..::..:...:|:.|.......|::.   |..|.
  Rat   652 MLVTLQS---------QGDNAHKE----TSIMGKDATEGGTLERTFSRGSYRDSLRASIRQRSKS 703

  Fly   705 YFKVLGH--PLVVVLILLMFVVARSSEATMDIFLSKWATWEETEPNQHEP--------IPEYH-- 757
            ...:|.|  ||.|......:..::.::..:          ||.||   .|        |||:|
  Rat   704 QLSLLTHDPPLAVADHKSSYKDSKDNDVLV----------EEVEP---APVRRILKYNIPEWHYI 755

  Fly   758 ------------------------------------RTRLRMMILYTFLILCTLIFYVLRTFGFF 786
                                                |:.:..|.|:..::.|..||
  Rat   756 LVGSLSAAINGAVTPIYSLLFSQLLGTFSLLDKEQQRSEIHSMCLFFVILGCVSIF--------- 811

  Fly   787 MMTLRISLRIHDQLFQGVIRAFMHFFTLATSGRILNR----------FSSDV------------- 828
                       .|..||        :|.|.||.:|.:          ...|:
  Rat   812 -----------TQFLQG--------YTFAKSGELLTKRLRKFGFKAMLGQDIGWFDDLRNNPGVL 857

  Fly   829 ---LAIDVNLPQA--------MMDSIEFAVNALAV-------LAVVSTANI-WLLIPATVVVALL 874
               ||.|.:..|.        |::|....:.||.:       |:::.|... :|.:...|...:|
  Rat   858 TTRLATDASQVQGATGSQVGMMVNSFTNIIAALLIAFFFSWKLSLIITIFFPFLALSGAVQTKML 922

  Fly   875 YGCRCLYIGASRSLKRIETISRSPIYSHTNATFKGLATIRALNGTKYMERDFHYYQNE-NTSALY 938
            .|.      ||:..:.:|...:        .|.:.|:.||.:.|.....|....::.| .||
  Rat   923 TGF------ASQDKQALEKAGQ--------ITSEALSNIRTVAGIGVEGRFIKAFEVELQTS--- 970

  Fly   939 LHVSINRA------FAFWTDLICVLYILAVTFSFLLFDKHRGYYSGDVGLAITQSMKLVLMCQAG 997
            ...::.:|      |||...:.    .||.:.::    ::.||.....||..:...::|
  Rat   971 YKTAVRKANIYGLCFAFSQGIA----FLANSAAY----RYGGYLIAYEGLGFSHVFRVV------ 1021

  Fly   998 MRQTVELENMMTSVERVMEYVNIPSEPAY--------------ETEESVNL----PKHWPS-GGQ 1043
              .:|.|.  .|:|.|...|.     |:|              :.:..:|:    .:.|.: .|:
  Rat  1022 --SSVALS--ATAVGRTFSYT-----PSYAKAKISAARFFQLLDRKPPINVYSEAGEKWDNFQGK 1077

  Fly  1044 LDFRDLRLRY-SNHGPYILKGLTFTIRGEEKIGIVGHTAAGKSSIVHALFRLAHIN-GHISIDGF 1106
            :||.|.:..| |.....:|.||:.::...:.:..||.:..|||:.:..|.|....: |.:.|||.
  Rat  1078 IDFIDCKFTYPSRPDIQVLNGLSVSVNPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGTVMIDGH 1142

  Fly  1107 ETSQLGLHDLRRRISIIPQDPVLFSGSLRFNL---DPFEEKTDEELWLALEAVKLKEFVSNLKDG 1168
            ::.::.:..||..|.|:.|:||||..|:..|:   |..:|.:.|....|.:..:|.:||.:|.:.
  Rat  1143 DSKKVNIQFLRSNIGIVSQEPVLFDCSIMDNIKYGDNTKEISVERAIAAAKQAQLHDFVMSLPEK 1207

  Fly  1169 INCRLHDCGANFSMGQRQLVCLARALLRQNKILIMDEATANVDPETDNLIQEAIHTKFAHCTVLT 1233
            ....:...|:..|.|::|.:.:|||::|..|||::||||:.:|.|::..:|.|:.......|.:.
  Rat  1208 YETNVGIQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQTALDKAREGRTCIV 1272

  Fly  1234 IAHRLHTVMDNDRVMVVDMGRVVELGHPHELLHNRHGYLHRFV 1276
            |||||.|:.::|.:.||..|.|:|.| .||.|..:.|..::.|
  Rat  1273 IAHRLSTIQNSDIIAVVSQGVVIEKG-THEKLMAQKGAYYKLV 1314

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	287/1333 (22%)
		ABC_membrane	92..358	CDD:294371	53/283 (19%)
		ABCC_MRP_domain1	423..626	CDD:213217	63/216 (29%)
		ABC_membrane	762..988	CDD:294371	50/274 (18%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	72/223 (32%)
Abcb11	NP_113948.1	PTZ00265	150..1314	CDD:240339	277/1315 (21%)
		Interaction with HAX1. /evidence=ECO:0000269|PubMed:15159385	651..674		4/35 (11%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000