DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and ABCC9

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_191575.2	Gene:	ABCC9 / 825186	AraportID:	AT3G60160	Length:	1506	Species:	Arabidopsis thaliana

Alignment Length:	1327	Identity:	400/1327 - (30%)
Similarity:	663/1327 - (49%)	Gaps:	130/1327 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 NPVTKANFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLGHWEQELKRSKP-- 73
            :|...|..|.:..|.|...:...|.:|.|:..|:    |.::....:.|....::|:||.:|.
plant   235 SPYGNATLFQRITFSWINPLFSLGYKRPLEKDDV----PDIDVKDSARFCSHAFDQKLKTTKEKE 295

  Fly    74 ---------NVLRMIFKAYGWSFVPASIVYSIMAIAVHTTQPLMLGGLVSFFSESTGKITKHSAY 129
                     :|||     |.|.....:.|::::..:.....|.::...|.|.||...:...| .|
plant   296 GPGNAFFYNSVLR-----YVWRKAAINAVFAVVNASTAYIGPYLINDFVEFLSEKQSQSLNH-GY 354

  Fly   130 LYAMGVVLCSLISGLFFHPFMKYLFRVGSRVRLACAGLVYRKFLRVSVAADNSGVSGYAISLMAT 194
            |.|:|.:...::..:....::....::|.|:|.|....:|:|.|.:|..:..|..||..|:.|:.
plant   355 LLALGFLTAKIVETVTQRQWIFGARQLGLRLRAALISHIYQKGLVLSSQSRQSHTSGEIINYMSV 419

  Fly   195 DLPTFNESFYCFHELWRGPLEGVVFVYIIYQLIGWPAVVGLGTIVAFIPLQAWAARAIARYKRSS 259
            |:....:..:..:.:|..|::....:||:.:.:|..|:..|.|.:..:.......|....|:...
plant   420 DVQRITDFIWYVNNIWMLPIQIFSAIYILQKHLGLGALAALVTTLMVMACNYPLTRLQRNYQSDI 484

  Fly   260 ADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIRGS-------TYIYAGLQCT 317
            .:..|:|:|..:||:..|:::|:.||:..|...:..:||:|.|.:..|       |:|..|  ..
plant   485 MNAKDDRMKATSEILKNMKILKLQAWDNQFLNKVKTLRKKEYDCLWKSLRLQAFTTFILWG--AP 547

  Fly   318 GMISKLSLFLSLVTYVFTGDIVTSQKVFIVASYYDHLNDSLLHSWPLAINMWVETFVVANRVKDF 382
            .:||    .::.||.:..|..:|:..|....:.:..| .|.:...|..::..|::.|.|:|:..:
plant   548 SLIS----VVTFVTCMLMGVKLTAGAVLSALATFQML-QSPIFGLPDLLSALVQSKVSADRIASY 607

  Fly   383 LFQHENPADGGVHNFKEAEDNPEHGNFFGRTHKPKAEVKSITVHKLSASWDQKKQEKRHRHIEDV 447
            |.|.|...|...:..|   |:.|               .|:.:...:.||:   .|.....::|:
plant   608 LQQSETQKDAVEYCSK---DHTE---------------LSVEIENGAFSWE---PESSRPTLDDI 651

  Fly   448 SFQAQDQQFVGIVGTVGAGKSTLLQVILGELDIISGSVEVNGVLSYAPQEPWLLRGSLRDNILFT 512
            ..:.:....|.:.|.||:|||:||..||||:..:.|:|.|:|..:|.||.||:|.|::||||||.
plant   652 ELKVKSGMKVAVCGAVGSGKSSLLSSILGEIQKLKGTVRVSGKQAYVPQSPWILSGTIRDNILFG 716

  Fly   513 EPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLARAVYRKADIYLLDDP 577
            ..|:.::|...::.|.|.:|.|....||.|.:||.|.::|||||.|:.:|||||:.|||||||||
plant   717 SMYESEKYERTVKACALIKDFELFSNGDLTEIGERGINMSGGQKQRIQIARAVYQNADIYLLDDP 781

  Fly   578 LSAVDSHVSKMLLDRCLNEFLSKKIRILVTHRVQLLRHVDHLVLLEGGRISVQGHY-DALKKLIR 641
            .||||:|..:.|.:.||...|..|..:.|||:|:.|...|.:::::.||:...|.: :.||:.|.
plant   782 FSAVDAHTGRELFEDCLMGILKDKTVLYVTHQVEFLPAADLILVMQNGRVMQAGKFEELLKQNIG 846

  Fly   642 FRMSVA--NDVEVAKLRAMRTDSVYEEPEPRKSLSQEE----HMD-RHEIEQQFK---------E 690
            |.:.|.  |:...:.|...::...::|.....:.|..|    |.| .|.|..:.|         |
plant   847 FEVLVGAHNEALDSILSIEKSSRNFKEGSKDDTASIAESLQTHCDSEHNISTENKKKEAKLVQDE 911

  Fly   691 QQQIGSVKLQTYKEYFKVLGHPLVVVLILLMFVVARSSEATMDIFLSKWATWEETEPNQHEPIPE 755
            :.:.|.:..:.|..|...:...|:|..|:|    |:|....:.|..:.|..|  |.|...|.||:
plant   912 ETEKGVIGKEVYLAYLTTVKGGLLVPFIIL----AQSCFQMLQIASNYWMAW--TAPPTAESIPK 970

  Fly   756 YHRTRLRMMILYTFLI----LCTLIFYVLRTFGFFMMTLRISLRIHDQLFQGVIRAFMHFFTLAT 816
            ....|:  :::|..|.    ||.|...:|...|    .|..:.....::...:.||.|.||....
plant   971 LGMGRI--LLVYALLAAGSSLCVLARTILVAIG----GLSTAETFFSRMLCSIFRAPMSFFDSTP 1029

  Fly   817 SGRILNRFSSDVLAIDVNLPQAMMDSIEFAVN----ALAVLAVVSTANI-----W----LLIPAT 868
            :||||||.|:|         |:::| :|.||.    |.:::.:|.|..:     |    :.||
plant  1030 TGRILNRASTD---------QSVLD-LEMAVKLGWCAFSIIQIVGTIFVMSQVAWQVCVIFIP-- 1082

  Fly   869 VVVALLYGCRCLYIGASRSLKRIETISRSPIYSHTNATFKGLATIRALNGTKYMERDFHYYQN-- 931
            |.||.::..| .|...:|.|.|:..:.|:||..|...:..|..||||.:     :||.....|
plant  1083 VAVACVFYQR-YYTPTARELSRMSGVERAPILHHFAESLAGATTIRAFD-----QRDRFISSNLV 1141

  Fly   932 --ENTSALYLHVSINRAFAFWTDLICVLYILAVTFSF-LLFDKHRGYYSGDV-GLAITQSMKLVL 992
              ::.|..:.||:  .|..:.:..:.:|......||. ||.....|..:..: ||.:|..:.|.:
plant  1142 LIDSHSRPWFHVA--SAMEWLSFRLNLLSHFVFAFSLVLLVTLPEGVINPSIAGLGVTYGLSLNV 1204

  Fly   993 MCQAGMRQTVELENMMTSVERVMEYVNIPSEPAYETEESVNLPKHWPSGGQLDFRDLRLRYSNHG 1057
            :....:......||.|.||||:::|..||||.....:....| .:||:.|.:.||||::||:.|.
plant  1205 LQATVIWNICNAENKMISVERILQYSKIPSEAPLVIDGHRPL-DNWPNVGSIVFRDLQVRYAEHF 1268

  Fly  1058 PYILKGLTFTIRGEEKIGIVGHTAAGKSSIVHALFRLAH-INGHISIDGFETSQLGLHDLRRRIS 1121
            |.:||.:|....|.:|||:||.|.:|||:::.||||:.. ..|.|.||..:.:::||||||.|:.
plant  1269 PAVLKNITCEFPGGKKIGVVGRTGSGKSTLIQALFRIVEPSQGTIVIDNVDITKIGLHDLRSRLG 1333

  Fly  1122 IIPQDPVLFSGSLRFNLDPFEEKTDEELWLALEAVKLKEFVSNLKDGINCRLHDCGANFSMGQRQ 1186
            ||||||.||.|::|.||||..:.||.|:|.|::..:|.:.:....:.::..:.:.|.|:|:||||
plant  1334 IIPQDPALFDGTIRLNLDPLAQYTDHEIWEAIDKCQLGDVIRAKDERLDATVVENGENWSVGQRQ 1398

  Fly  1187 LVCLARALLRQNKILIMDEATANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVD 1251
            ||||.|.||:::.||::|||||:||..||.:||:.|:.:|...||:|||||:|||:::|.|:|:.
plant  1399 LVCLGRVLLKKSNILVLDEATASVDSATDGVIQKIINQEFKDRTVVTIAHRIHTVIESDLVLVLS 1463

  Fly  1252 MGRVVELGHPHELLHNRHGYLHRFVEK 1278
            .||:.|...|.:||.....:..:.:::
plant  1464 DGRIAEFDSPAKLLQREDSFFSKLIKE 1490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	400/1315 (30%)
		ABC_membrane	92..358	CDD:294371	61/272 (22%)
		ABCC_MRP_domain1	423..626	CDD:213217	82/202 (41%)
		ABC_membrane	762..988	CDD:294371	65/248 (26%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	102/219 (47%)
ABCC9	NP_191575.2	PLN03232	68..1488	CDD:215640	400/1323 (30%)
		ABC_membrane	319..586	CDD:294371	62/274 (23%)
		ABCC_MRP_domain1	630..830	CDD:213217	82/202 (41%)
		ABC_membrane	973..1209	CDD:294371	67/261 (26%)
		ABCC_MRP_domain2	1253..1473	CDD:213211	102/219 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720