DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and ABCC10

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_191473.2	Gene:	ABCC10 / 825083	AraportID:	AT3G59140	Length:	1453	Species:	Arabidopsis thaliana

Alignment Length:	1332	Identity:	394/1332 - (29%)
Similarity:	665/1332 - (49%)	Gaps:	166/1332 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 KANFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLGHWEQELKRSK------- 72
            ||..||...|.|...::.:|..::|:..|:    |.|...:.:......:|:.|...|
plant   209 KAGLFSTLSFWWLNSLIKRGNVKDLEEEDI----PELRKEERAETCYSLFEENLIEQKRRLGSSC 269

  Fly    73 -PNVLRMIFKAYGWSFVPASIVYSIMAIAVHTTQPLMLGGLVSFFSESTGKITKHSAYLYAMGVV 136
             |::|::..... |..:..|..::.|.|...:..||:|...:        .:.:.:|.....|:|
plant   270 QPSILKVTVLCV-WRELLTSGFFAFMKIVAVSAGPLLLNAFI--------LVAEGNASFRYEGLV 325

  Fly   137 LCSLISGLFFHPFMKYL------FR---VGSRVRLACAGLVYRKFLRVSVAA----DNSGVSGYA 188
            |..|   |||...::.|      ||   ||.|||......:.:|.||::.::    ..|.:..||
plant   326 LAVL---LFFSKMIESLSQRQWYFRCRIVGLRVRSLLTAAINKKQLRLNNSSRLIHSGSEIMNYA 387

  Fly   189 ISLMATDLPTFNESFYCFHELWRGPLEGVVFVYIIYQLIGWPAVVGLGTIVAFIPLQAWAARAIA 253
                ..|.....|..|.||:||....:.::.:.|::..:|......|..|:..:...|..|:...
plant   388 ----TVDAYRIGEFPYWFHQLWTTSFQLLIALGILFHSVGVATFSALAVIILTVLCNAPIAKLQN 448

  Fly   254 RYKRSSADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIRG--STYIYAGLQC 316
            :::.......|||:|..||.:..|:::|:||||..|.|:|.|:|..|:.|::.  ....|..:
plant   449 KFQSELMTSQDERLKACNESLVNMKVLKLYAWESHFKKVIEKLRNIELKSLKAVQMRKAYNAV-- 511

  Fly   317 TGMISKLSLFLSLVTYV---FTGDIVTSQKVFIVASYYDHLNDSLLHSWPLAINMWVETFVVANR 378
              :.....:|:|..|:.   |....:.:..||...:....:.|. :...|..|.:.::..|..:|
plant   512 --LFWSSPVFVSAATFATCYFLDIPLRASNVFTFVATLRLVQDP-VRMIPDVIGVTIQAKVAFSR 573

  Fly   379 VKDFLFQHENP-ADGGVHNFKEAEDNPEHGNFFGRTHKPKAEVKSITVHKLSASWDQKKQEKRHR 442
            :..||   |.| ..||....|:..:..::               :|.:...|.||::|...|  .
plant   574 IATFL---EAPELQGGERRRKQRSEGNQN---------------AIIIKSASFSWEEKGSTK--P 618

  Fly   443 HIEDVSFQAQDQQFVGIVGTVGAGKSTLLQVILGELDIISGSVEVNGVLSYAPQEPWLLRGSLRD 507
            ::.:||.:.:..:.|.:.|.||:||||||..||||...:||:::..|.::|..|..|:..|::||
plant   619 NLRNVSLEVKFGEKVAVCGEVGSGKSTLLAAILGETPCVSGTIDFYGTIAYVSQTAWIQTGTIRD 683

  Fly   508 NILFTEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLARAVYRKADIY 572
            ||||....||.||.|.::...||:|:|.||.||.|.:||.|.:||||||.|:.||||:|:.||||
plant   684 NILFGGVMDEHRYRETIQKSSLDKDLELLPDGDQTEIGERGVNLSGGQKQRIQLARALYQDADIY 748

  Fly   573 LLDDPLSAVDSHVSKMLLDRCLNEFLSKKIRILVTHRVQLLRHVDHLVLLEGGRISVQGHYDAL- 636
            |||||.||||:|.:..|....:.:.|:.|..:||||:|..|...|.::|:..|.|:....|..|
plant   749 LLDDPFSAVDAHTASSLFQEYVMDALAGKAVLLVTHQVDFLPAFDSVLLMSDGEITEADTYQELL 813

  Fly   637 ------KKLIRFRMSVANDVEVAKLRAMRTDSVYEEP-EPRKSL-----SQEEHMDRHEIEQQFK 689
                  :.|:......|....|..:         |.| :|.|.:     ||.:.:....:.:|
plant   814 ARSRDFQDLVNAHRETAGSERVVAV---------ENPTKPVKEINRVISSQSKVLKPSRLIKQ-- 867

  Fly   690 EQQQIGSVKLQTYKEYF-KVLGHPLVVVLILLMFVVARSSEATM---DIFLSKWATWEETEPNQH 750
            |:::.|...|:.|.:|. :..|:        :.|.:|..::.|.   .|..:.|.......|..
plant   868 EEREKGDTGLRPYIQYMNQNKGY--------IFFFIASLAQVTFAVGQILQNSWMAANVDNPQV- 923

  Fly   751 EPIPEYHRTRLRMMILYTFLILCTLIFYVLRTFGFFMMTLRISLRIHDQLFQGVIRAFMHFFTLA 815
                    :.|:::::|..:.||:::..::|:....:|.::.|..:..||...:.||.|.|:...
plant   924 --------STLKLILVYLLIGLCSVLCLMVRSVCVVIMCMKSSASLFSQLLNSLFRAPMSFYDST 980

  Fly   816 TSGRILNRFSSDVLAIDVNLPQAMMDSIEFAVN---ALAVLAVVSTANIWLLIPATVVVALLYGC 877
            ..||||:|.|||:..:|:::|..::..:..:||   :|.|||:|:...:::.:|   :|.|.:..
plant   981 PLGRILSRVSSDLSIVDLDVPFGLIFVVASSVNTGCSLGVLAIVTWQVLFVSVP---MVYLAFRL 1042

  Fly   878 RCLYIGASRSLKRIETISRSPIYSHTNATFKGLATIRALN-GTKYMERD-----------FHYY- 929
            :..|...::.|.||...:||.:.:|...:..|..||||.: ..::.::.           ||.:
plant  1043 QKYYFQTAKELMRINGTTRSYVANHLAESVAGAITIRAFDEEERFFKKSLTLIDTNASPFFHSFA 1107

  Fly   930 -------QNENTSALYLHVSINRAFAFWTDLICVLYILAVTFSFLLFDKHRGYYSGDVGLAITQS 987
                   :.|..||:.|   .:.||       |::.:...|||           ||.:|:|::..
plant  1108 ANEWLIQRLETVSAIVL---ASTAF-------CMILLPTGTFS-----------SGFIGMALSYG 1151

  Fly   988 MKLVLMCQAGMRQTVELENMMTSVERVMEYVNIPSEPAYETEESVNLPKHWPSGGQLDFRDLRLR 1052
            :.|.:.....::....|.|.:.||||:.:|.::..| |.|..|....|.:||..|:::..||::|
plant  1152 LSLNMGLVYSVQNQCYLANWIISVERLNQYTHLTPE-APEVIEETRPPVNWPVTGRVEISDLQIR 1215

  Fly  1053 YSNHGPYILKGLTFTIRGEEKIGIVGHTAAGKSSIVHALFRLAH-INGHISIDGFETSQLGLHDL 1116
            |....|.:|||::.|..|..||||||.|.:||::::.|||||.. :.|.|.:||.:.|::|:|||
plant  1216 YRRESPLVLKGISCTFEGGHKIGIVGRTGSGKTTLISALFRLVEPVGGKIVVDGVDISKIGVHDL 1280

  Fly  1117 RRRISIIPQDPVLFSGSLRFNLDPFEEKTDEELWLALEAVKLKEFVSNLKDGINCRLHDCGANFS 1181
            |.|..||||||.||:|::||||||..:.:|.|:|..|...:|||.|...::|::..:.:.|:|:|
plant  1281 RSRFGIIPQDPTLFNGTVRFNLDPLCQHSDAEIWEVLGKCQLKEVVQEKENGLDSLVVEDGSNWS 1345

  Fly  1182 MGQRQLVCLARALLRQNKILIMDEATANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDR 1246
            ||||||.||.||:||::::|::|||||::|..||.::|:.|..:||.|||:|:|||:.||||...
plant  1346 MGQRQLFCLGRAVLRRSRVLVLDEATASIDNATDLILQKTIRREFADCTVITVAHRIPTVMDCTM 1410

  Fly  1247 VMVVDMGRVVELGHPHELLHNRHGYLHRFVEK 1278
            |:.:..||:||...|.:|:.:.:....:.|::
plant  1411 VLSISDGRIVEYDEPMKLMKDENSLFGKLVKE 1442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	393/1320 (30%)
		ABC_membrane	92..358	CDD:294371	67/283 (24%)
		ABCC_MRP_domain1	423..626	CDD:213217	89/202 (44%)
		ABC_membrane	762..988	CDD:294371	60/248 (24%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	104/219 (47%)
ABCC10	NP_191473.2	MRP_assoc_pro	194..1437	CDD:188098	393/1325 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.720