DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and ABCC8

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_001326629.1	Gene:	ABCC8 / 821679	AraportID:	AT3G21250	Length:	1470	Species:	Arabidopsis thaliana

Alignment Length:	1336	Identity:	405/1336 - (30%)
Similarity:	666/1336 - (49%)	Gaps:	153/1336 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 NP------VTKANFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLES-------TQVSSFLLG 62
            ||      :..|.|||...|.|...:|..|.::.|.|.|:....|..|:       :|....|||
plant   201 NPRKESARLATAGFFSILSFSWMNPLLSLGFKKPLSPEDIPSVVPEDEAQLAYKKFSQAWDTLLG 265

  Fly    63 HWEQELKRSKPNVLRMIFKAYGWSFVPASIVYSIMAIAVHTTQPLMLGGLVSFFSESTGKITKHS 127
              ::...:.:..|.|.:.|.|....:..::...:...|| .:.||||...|. ::.|..:..::.
plant   266 --DESSTKERNLVFRAVVKVYFKENIFIAVFAFLRTFAV-VSLPLMLYVFVD-YANSDHRDLRNG 326

  Fly   128 AYLYAMGVVLCSLISGLFFHPFMKYLFRVGSRVRLACAGLVYRKFLRVSVAADNSGVSGYAISLM 192
            .:..|. :|:..|:..|....:.....|.|.|:|.|.....|:|.|::|........||..::.:
plant   327 FFNLAC-LVMLKLVESLTMRHWYFASRRSGMRIRSALMVAAYKKQLKLSSLGRKRHSSGEIVNYI 390

  Fly   193 ATDLPTFNESFYCFHELWRGPLEGVVFVYIIYQLIGWPAVVGLGTIVAFIPLQAWAARAIARYKR 257
            |.|.....|..:.||..|...|:.::...:::.::|..|..||..::....|....|:.:...:.
plant   391 AVDAYRMGEFLWWFHSGWSLSLQLLLSTAVLFGVVGAGAFPGLILLLLCGLLNLPFAKMLQNCQT 455

  Fly   258 SSADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIRGSTYIYAGLQCTGMISK 322
            ......|:|::..:||:.:|::||:.:||..|.|.|...|.:|.      |:: |..|.|.....
plant   456 QFMIAQDKRLRSTSEILNSMKVIKLQSWEDEFKKKIESCRDDEF------TWL-AKAQLTKAFGS 513

  Fly   323 LSLFLS---LVTYVFTGDIVTSQKVFIVASYYDHLNDSLLHSWPL-----AINMWVETFVVANRV 379
            ...::|   :.:.||.|..:........::.:..|....:.|.|:     ||:..::..|...|:
plant   514 FLYWMSPTIVSSVVFLGCALLKSAPLNASTIFTVLATLRVMSEPVKIIPDAISAIIQGNVSFQRL 578

  Fly   380 KDFLFQHENPAD----GGVHNFKEAEDNPEHGNFFGRTHKPKAEVKSITVHKLSASWDQKKQEKR 440
            .:||...|...|    .|:.....|.| .:.|||   ..:|:.::.::                |
plant   579 NNFLLDDELKMDEIERSGLDASGTAVD-IQVGNF---GWEPETKIPTL----------------R 623

  Fly   441 HRHIEDVSFQAQDQQFVGIVGTVGAGKSTLLQVILGELDIISGSVEVNGVLSYAPQEPWLLRGSL 505
            :.|:|     .:..|.|.:.|.||||||:||..:|||:..:||:|:|.|.::|..|..|:..|::
plant   624 NIHLE-----IKHGQKVAVCGPVGAGKSSLLHAVLGEIPKVSGTVKVFGSIAYVSQTSWIQSGTI 683

  Fly   506 RDNILFTEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLARAVYRKAD 570
            |||||:.:|.:.:||...::.|.||:|:.....||.|.:|:.|.:||||||.|:.||||||..||
plant   684 RDNILYGKPMESRRYNAAIKACALDKDMNGFGHGDLTEIGQRGINLSGGQKQRIQLARAVYADAD 748

  Fly   571 IYLLDDPLSAVDSHVSKMLLDRCLNEFLSKKIRILVTHRVQLLRHVDHLVLLEGGRISVQGHYD- 634
            :||||||.||||:|.:.:|..:|:.:.|.:|..|||||:|:.|..||.::::|.|.|:..|.|:
plant   749 VYLLDDPFSAVDAHTAGVLFHKCVEDSLKEKTVILVTHQVEFLSEVDQILVMEEGTITQSGKYEE 813

  Fly   635 ------ALKKLIRFRMSVANDVEVA------------KLRAMRTDSVYEEPEPRKSLSQEEHMDR 681
                  |.::|:.........:.:|            |.|.:|..:|.|:.|     .:.|..|.
plant   814 LLMMGTAFQQLVNAHNDAVTVLPLASNESLGDLRKEGKDREIRNMTVVEKIE-----EEIEKTDI 873

  Fly   682 HEIEQQFKEQQQIGSVKLQTYKEYFKV-LGHPLV--VVLILLMFVVARSSEATMDIFLSKWATWE 743
            ..::...:|:::.|.|.::.:.:|..| .|..|:  .||..:.|||.:::.       :.|..:.
plant   874 PGVQLTQEEEKESGYVGMKPFLDYIGVSRGWCLLWSSVLGQVGFVVFQAAS-------TYWLAFA 931

  Fly   744 ETEPNQHEPIPEYHRTRLRMMILYTFLILCTLIFYVLRTFGFF----MMTLRISLRIHDQLFQG- 803
                   ..||:...|    |::..:.|:.||      :.||.    :.|..:.|:.....|.|
plant   932 -------IGIPKITNT----MLIGVYSIISTL------SAGFVYARAITTAHLGLKASKAFFSGF 979

  Fly   804 ---VIRAFMHFFTLATSGRILNRFSSDVLAIDVNLPQAMMDSIEFAVNALAVLAVVSTANIWLLI 865
               |.:|.|.||.....||||.|.|||:..:|.::|.|.:..:..||...|.|.:::.....::|
plant   980 TNAVFKAPMLFFDSTPVGRILTRASSDLNVLDYDVPFAFIFVVAPAVELTAALLIMTYVTWQVII 1044

  Fly   866 PATVVVALLYGCRCLYIGASRSLKRIETISRSPIYSHTNATFKGLATIRALNGTKYMERDFHYYQ 930
            .|.:.:|.....:..|:.::|.|.||...:::|:.::...|..|:.||||. ||  .||.|..|.
plant  1045 IALLALAATKVVQDYYLASARELIRINGTTKAPVMNYAAETSLGVVTIRAF-GT--AERFFKNYL 1106

  Fly   931 N--ENTSALYLHVSINRAFAFW-----------TDLICVLYILAVTFSFLLFDKHRGYYS-GDVG 981
            |  :..:.|:.   ::.|...|           |...|.|.::.:.         :||.: |.||
plant  1107 NLVDADAVLFF---LSNAAMEWVILRIETLQNVTLFTCALLLILIP---------KGYIAPGLVG 1159

  Fly   982 LAITQSMKLVLMCQAGMRQTVELENMMTSVERVMEYVNIPSEPAYETEESVNLPKHWPSGGQLDF 1046
            |:::.::.|........|....|.|.:.||||:.:|:|||.||....::. ..|..|||.|.:..
plant  1160 LSLSYALTLTQTQVFLTRWYCTLSNSIISVERIKQYMNIPEEPPAIIDDK-RPPSSWPSNGTIHL 1223

  Fly  1047 RDLRLRYSNHGPYILKGLTFTIRGEEKIGIVGHTAAGKSSIVHALFRLAH-INGHISIDGFETSQ 1110
            ::|::||..:.|.:|||::.|.|...::|:||.|.:|||:::.|||||.. .:|.|.|||.:.|:
plant  1224 QELKIRYRPNAPLVLKGISCTFREGTRVGVVGRTGSGKSTLISALFRLVEPASGCILIDGIDISK 1288

  Fly  1111 LGLHDLRRRISIIPQDPVLFSGSLRFNLDPFEEKTDEELWLALEAVKLKEFVSNLKDGINCRLHD 1175
            :||.|||.::|||||:|.||.|.:|.||||....:|:|:|.|||..:||..:|||.:.::..:.|
plant  1289 IGLKDLRMKLSIIPQEPTLFRGCIRTNLDPLGVYSDDEIWKALEKCQLKTTISNLPNKLDSSVSD 1353

  Fly  1176 CGANFSMGQRQLVCLARALLRQNKILIMDEATANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHT 1240
            .|.|:|:|||||.||.|.||::||||::|||||::|..||.:||..|..:||.|||:|:|||:.|
plant  1354 EGENWSVGQRQLFCLGRVLLKRNKILVLDEATASIDSATDAIIQRIIREEFADCTVITVAHRVPT 1418

  Fly  1241 VMDNDRVMVVDMGRVVELGHPHELLHNRHGYLHRFV 1276
            |:|:|.|||:..|.:||...|.:|:.. ..|..:.|
plant  1419 VIDSDMVMVLSFGDLVEYNEPSKLMET-DSYFSKLV 1453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	403/1326 (30%)
		ABC_membrane	92..358	CDD:294371	59/268 (22%)
		ABCC_MRP_domain1	423..626	CDD:213217	83/202 (41%)
		ABC_membrane	762..988	CDD:294371	64/247 (26%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	106/219 (48%)
ABCC8	NP_001326629.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720