DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and ABCC7

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_187917.3	Gene:	ABCC7 / 820498	AraportID:	AT3G13100	Length:	1493	Species:	Arabidopsis thaliana

Alignment Length:	1322	Identity:	390/1322 - (29%)
Similarity:	652/1322 - (49%)	Gaps:	135/1322 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PVTKANFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLG------HWEQ-ELK 69
            |.:.|.|.|...|.|...::|.|.::.:|..|:    |.::::..:..|..      .|:. |.:
plant   231 PFSNAGFLSHVSFSWMSPLIVLGNEKIIDSEDV----PQVDNSDRAEKLFWIFRSKLEWDDGERR 291

  Fly    70 RSKPNVLRMIFKAYGWSFVPASIVYS-IMAIAVHTTQPLM------LGGLVSFFSESTGKITKHS 127
            .:...:::.:|.:. |..:..|.::: :..::.:....||      |.|...:.::....:|.
plant   292 ITTYKLIKALFFSV-WRDILLSTLFAFVYTVSCYVAPYLMDTFVQYLNGQRQYSNQGVVLVTT-- 353

  Fly   128 AYLYAMGVVLCSLISGLFFHPFMKYLFRVGSRVRLACAGLVYRKFLRVSVAADNSGVSGYAISLM 192
              .:...:|.|......:|.     |.:.|..:|.....::|.|.|.:...:.....||..|:||
plant   354 --FFVAKLVECQARRNWYFR-----LQKAGIGMRSVLVSMIYEKGLTLPCYSKQGHTSGEIINLM 411

  Fly   193 ATDLPTFNESFYCFHELWRGPLEGVVFVYIIYQLIGWPAVVGLGTIVAF----------IPLQAW 247
            ..|....:...:..|:.|...|:..:.:.|:|:.:      |||:|.||          |||
plant   412 TVDAERISAFSWYMHDPWILVLQISLALLILYRSL------GLGSIAAFAATFLVMLGNIPL--- 467

  Fly   248 AARAIARYKRSSADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIRGSTYIYA 312
             |:...:::.:..:..|.|:|..:|.:..|:::|:..||..|...|..:|..|...::  .::|.
plant   468 -AKLEEKFQGNLMESKDNRMKKTSEALLNMRILKLQGWEMKFLHKILDLRGIEAGWLK--KFVYN 529

  Fly   313 GLQCTGMISKLSLFLSLVTY---------VFTGDIVTSQKVFIVASYYDHLNDSLLHSWPLAINM 368
            ....:.::.....|:|...:         :.:|.|:.:...|       .:..:.::..|..|:|
plant   530 SAAISSVLWAAPSFVSATAFGACMLLKIPLESGKIIAALATF-------RILQTPIYKLPDTISM 587

  Fly   369 WVETFVVANRVKDFLFQHENPADGGVHNFKEAEDNPEHGNFFGRTHKPKAEVK-SITVHKLSASW 432
            .|:|.|..:|:..||...:...|                   |....|....| .:.|...:.||
plant   588 IVQTKVSLDRIATFLCLDDLQQD-------------------GMERLPSGSSKMDVEVSNGAFSW 633

  Fly   433 DQKKQEKRHRHIEDVSFQAQDQQFVGIVGTVGAGKSTLLQVILGELDIISGSVEVNGVLSYAPQE 497
            |.......   ::|:.|:......:.|.||||:|||:||..||||:..|||:::|.|..:|..|.
plant   634 DDSSPIPT---LKDIRFKIPHGMNIAICGTVGSGKSSLLSSILGEVPKISGNLKVCGRKAYIAQS 695

  Fly   498 PWLLRGSLRDNILFTEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLA 562
            ||:..|.:.:||||.:|...:.|..||..|.|::|:|..|..|.|.:||.|.:||||||.|:.:|
plant   696 PWIQSGKVEENILFGKPMQREWYQRVLEACSLNKDLEVFPFRDQTVIGERGINLSGGQKQRIQIA 760

  Fly   563 RAVYRKADIYLLDDPLSAVDSHVSKMLLDRCLNEFLSKKIRILVTHRVQLLRHVDHLVLLEGGRI 627
            ||:|:.|||||.|||.||||:|....|....|...|..|..|.|||:::.|...|.:::::.|||
plant   761 RALYQDADIYLFDDPFSAVDAHTGSHLFKEVLLGLLRNKTVIYVTHQLEFLPEADLILVMKDGRI 825

  Fly   628 SVQGHYDALKKLIRFRMSVANDVEVAKLRAMRTDSV-----YEE--PEPRKSLSQEEHMDRHEIE 685
            :..|.|:.:         :.:..:..:|....||::     ||:  ...:.:.|:|..:...|.:
plant   826 TQAGKYNEI---------LESGTDFMELVGAHTDALAAVDSYEKGSASAQSTTSKESKVSNDEEK 881

  Fly   686 QQ-----------FKEQQQIGSVKLQTYKEYFKVLGHPLVVVLILLMFVVARSSEATMDIFLSKW 739
            |:           .:|:::.|.|....|::|.|:.....:|.:||::.::.:    .::|..:.|
plant   882 QEEDLPSPKGQLVQEEEREKGKVGFTVYQKYMKLAYGGALVPIILVVQILFQ----VLNIGSNYW 942

  Fly   740 ATWEETEPNQHEPIPEYHRTRLRMMILYTFLILCTLIFYVLRTFGFFMMTLRISLRIHDQLFQGV 804
            ..|........:|:.    :...::::|.||...:....::|.....|...:|:..:.:|:...:
plant   943 MAWVTPVSKDVKPLV----SGSTLILVYVFLATASSFCILVRAMLSAMTGFKIATELFNQMHFRI 1003

  Fly   805 IRAFMHFFTLATSGRILNRFSSDVLAIDVNLPQAMMDSIEFAVNALAVLAVVSTANIWLLIPATV 869
            .||.|.||.....||||||.|:|..|:|:.||....:....|||.|.::.|:......:||....
plant  1004 FRASMSFFDATPIGRILNRASTDQSAVDLRLPSQFSNLAIAAVNILGIIGVMGQVAWQVLIVFIP 1068

  Fly   870 VVALLYGCRCLYIGASRSLKRIETISRSPIYSHTNATFKGLATIRALNGTKYMERDFHYYQNENT 934
            |:|.....|..||.|:|.|.|:..|||||:..|.:.|..|:.|||:.:.......|. ...|:..
plant  1069 VIAACTWYRQYYISAARELARLSGISRSPLVQHFSETLSGITTIRSFDQEPRFRTDI-MRLNDCY 1132

  Fly   935 SALYLH-VSINRAFAFWTDLI-CVLYILAVTFSFLLFDKHRGYYSGD-VGLAITQSMKLVLMCQA 996
            |.|..| :|......|..||: .|.:.|::.   :|.....|..:.. .|||:|.::.|..: ||
plant  1133 SRLRFHAISAMEWLCFRLDLLSTVAFALSLV---ILVSVPEGVINPSFAGLAVTYALNLNSL-QA 1193

  Fly   997 GMRQTV-ELENMMTSVERVMEYVNIPSEPAYETEESVNLPKHWPSGGQLDFRDLRLRYSNHGPYI 1060
            .:..|: :|||.|.||||:::|::|||||:. ..||....|.||..|::...:|::||..|.|.:
plant  1194 TLIWTLCDLENKMISVERMLQYIDIPSEPSL-VIESTRPEKSWPCRGEITICNLQVRYGPHLPMV 1257

  Fly  1061 LKGLTFTIRGEEKIGIVGHTAAGKSSIVHALFRLAH-INGHISIDGFETSQLGLHDLRRRISIIP 1124
            |:|||.|.||..|.||||.|..|||:::..|||:.. ..|.|.|||.....:||||||.|:||||
plant  1258 LRGLTCTFRGGLKTGIVGRTGCGKSTLIQTLFRIVEPAAGEIRIDGINILTIGLHDLRSRLSIIP 1322

  Fly  1125 QDPVLFSGSLRFNLDPFEEKTDEELWLALEAVKLKEFVSNLKDGINCRLHDCGANFSMGQRQLVC 1189
            |:|.:|.|::|.||||.||..|:::|.||:..:|.:.:...:..::..:.:.|.|:|:|||||||
plant  1323 QEPTMFEGTVRSNLDPLEEYADDQIWEALDKCQLGDEIRKKELKLDSPVSENGQNWSVGQRQLVC 1387

  Fly  1190 LARALLRQNKILIMDEATANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGR 1254
            |.|.||:::|:||:|||||:||..||.||||.:...|:.|||:|||||:.:|:|:|.|:::|.|.
plant  1388 LGRVLLKRSKVLILDEATASVDTATDTLIQETLRQHFSGCTVITIAHRISSVIDSDMVLLLDQGL 1452

  Fly  1255 VVELGHPHELLHNRHGYLHRFV 1276
            :.|...|..||.::.....:.|
plant  1453 IEEHDSPARLLEDKSSSFSKLV 1474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	389/1312 (30%)
		ABC_membrane	92..358	CDD:294371	53/291 (18%)
		ABCC_MRP_domain1	423..626	CDD:213217	82/202 (41%)
		ABC_membrane	762..988	CDD:294371	68/228 (30%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	103/219 (47%)
ABCC7	NP_187917.3	PLN03232	34..1474	CDD:215640	389/1320 (29%)
		ABC_membrane	309..578	CDD:294371	54/296 (18%)
		ABCC_MRP_domain1	624..824	CDD:213217	82/202 (41%)
		ABC_membrane	925..1199	CDD:294371	77/286 (27%)
		ABCC_MRP_domain2	1239..1459	CDD:213211	103/219 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.720