DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and ABCC6

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_187916.3	Gene:	ABCC6 / 820497	AraportID:	AT3G13090	Length:	1466	Species:	Arabidopsis thaliana

Alignment Length:	1341	Identity:	410/1341 - (30%)
Similarity:	653/1341 - (48%)	Gaps:	172/1341 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PVTKANFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLG------HWEQ-ELK 69
            |.:||...|:..|.|...::..|.::.:|..|:    |.|:.:..:..|..      .|:. |.:
plant   208 PFSKAGILSRMSFSWMSPLITLGNEKIIDIKDV----PQLDRSDTTESLFWIFRSKLEWDDGERR 268

  Fly    70 RSKPNVLRMIFKAYGWSFVPASIVYSIMAIAVHTTQ----PLMLGGLVSFFSESTGKITKHSAYL 130
            .:...:::.:|.:. |    ..||.|.:...|:|..    |.::...|.:.:.:  :..|:..|:
plant   269 ITTFKLIKALFLSV-W----RDIVLSALLAFVYTVSCYVAPYLMDNFVQYLNGN--RQYKNQGYV 326

  Fly   131 -----YAMGVVLCSLISGLFFHPFMKYLFRVGSRVRLACAGLVYRKFLRVSVAADNSGVSGYAIS 190
                 :...:|.|......||..     .:.|..:|.....::|.|.|.:...:.....||..|:
plant   327 LVTTFFVAKLVECQTQRQWFFRG-----QKAGLGMRSVLVSMIYEKGLTLPCHSKQGHTSGEIIN 386

  Fly   191 LMATDLPTFNESFYCFHELWRGPLEGVVFVYIIYQLIGWPAVVGLGTIVAF-----IPLQAWA-A 249
            |||.|....:...:..|:.|...|:..:.::|:|:.:      |||:|.||     :.|..:. |
plant   387 LMAVDADRISAFSWFMHDPWILVLQVSLALWILYKSL------GLGSIAAFPATILVMLANYPFA 445

  Fly   250 RAIARYKRSSADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIRGSTYIYAGL 314
            :...:::.|.....|.|:|..:|::..|:::|:..||..|...|.::|..|...::  .::|...
plant   446 KLEEKFQSSLMKSKDNRMKKTSEVLLNMKILKLQGWEMKFLSKILELRHIEAGWLK--KFVYNSS 508

  Fly   315 QCTGMISKLSLFLSLVTY---------VFTGDIVTSQKVFIVASYYDHLNDSLLHSWPLAINMWV 370
            ....::.....|:|...:         :.:|.|:.:...|       .:....::..|..|:|.|
plant   509 AINSVLWAAPSFISATAFGACLLLKIPLESGKILAALATF-------RILQGPIYKLPETISMIV 566

  Fly   371 ETFVVANRVKDFLFQHENPADGGVHNFKEAEDNPEHGNFFGRTHKPKAEVKSITVHKLSASWDQK 435
            :|.|..||:..||...:...|                 ..||.....:|: ::.:...:.|||..
plant   567 QTKVSLNRIASFLCLDDLQQD-----------------VVGRLPSGSSEM-AVEISNGTFSWDDS 613

  Fly   436 KQEKRHRHIEDVSFQAQDQQFVGIVGTVGAGKSTLLQVILGELDIISGSVEVNGVLSYAPQEPWL 500
            .....   :.|::|:......|.|.||||:|||:||..||||:..|||:::|.|..:|..|.||:
plant   614 SPIPT---LRDMNFKVSQGMNVAICGTVGSGKSSLLSSILGEVPKISGNLKVCGRKAYIAQSPWI 675

  Fly   501 LRGSLRDNILFTEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLARAV 565
            ..|.:.:||||.:|.:.:.|..||..|.|::|:|.||..|.|.:||.|.:||||||.|:.:|||:
plant   676 QSGKVEENILFGKPMEREWYDRVLEACSLNKDLEILPFHDQTVIGERGINLSGGQKQRIQIARAL 740

  Fly   566 YRKADIYLLDDPLSAVDSHVSKMLLDRCLNEFLSKKIRILVTHRVQLLRHVDHLVLLEGGRISVQ 630
            |:.|||||.|||.||||:|....|....|...|..|..|.|||:|:.|...|.:::::.|:|:..
plant   741 YQDADIYLFDDPFSAVDAHTGSHLFKEVLLGLLRHKTVIYVTHQVEFLPEADLILVMKDGKITQA 805

  Fly   631 GHYDALKKLIRFRMSVANDVEV--AKLRAMRT-DSVYEEPEPRKSLSQEEHMDRHEIEQQ----- 687
            |.|..:..      |..:.:|:  |...|:.| ||........||.:.:|:...|..|:|
plant   806 GKYHEILD------SGTDFMELVGAHTEALATIDSCETGYASEKSTTDKENEVLHHKEKQENGSD 864

  Fly   688 --------FKEQQQIGSVKLQTYKEYFKVLGHPLVVVLILLMFVVARSSEATMDIFLSKWATW-- 742
                    .:|:::.|.|....||:|..:.....|:.|||::.|:.:    .:.|..:.|.||
plant   865 NKPSGQLVQEEEREKGKVGFTVYKKYMALAYGGAVIPLILVVQVLFQ----LLSIGSNYWMTWVT 925

  Fly   743 ---EETEPNQHEPIPEYHRTRLRMMILYTFLIL----CTLIFYVLRTFGFFMMTLRISLRIHDQL 800
               ::.||    |:..:     .::::|..|.:    |.||..:|.....|.|...:..::|.::
plant   926 PVSKDVEP----PVSGF-----TLILVYVLLAVASSFCILIRALLVAMTGFKMATELFTQMHLRI 981

  Fly   801 FQGVIRAFMHFFTLATSGRILNRFSSDVLAIDVNLPQAMMDSIEFAVNALAVLAVVSTANIWLLI 865
            |    ||.|.||.....||||||.|:|....|:.||.........|:|.|.::.|:......:||
plant   982 F----RASMSFFDATPMGRILNRASTDQSVADLRLPGQFAYVAIAAINILGIIGVIVQVAWQVLI 1042

  Fly   866 PATVVVALLYGCRCLYIGASRSLKRIETISRSPIYSHTNATFKGLATIRALN------------G 918
            ....|||.....|..||.|:|.|.|:..|||||:..|.:.|..|:.|||:.:            .
plant  1043 VFIPVVAACAWYRQYYISAARELARLAGISRSPVVHHFSETLSGITTIRSFDQEPRFRGDIMRLS 1107

  Fly   919 TKYMERDFHYYQNENTSALYLHVSINRAFAFWTDLICVLYILAVTFSF-----LLFDKHRGYYSG 978
            ..|....||     :|.|:              :.:|....|..||:|     :|.....|..:.
plant  1108 DCYSRLKFH-----STGAM--------------EWLCFRLELLSTFAFASSLVILVSAPEGVINP 1153

  Fly   979 DV-GLAITQSMKLVLMCQAGMRQTV-ELENMMTSVERVMEYVNIPSEPAYETEESVNLPKHWPSG 1041
            .: |||||.::.|..: ||.:..|: :|||.|.||||:::|.||||||.. ..|:....|.|||.
plant  1154 SLAGLAITYALNLNTL-QATLIWTLCDLENKMISVERMLQYTNIPSEPPL-VIETTRPEKSWPSR 1216

  Fly  1042 GQLDFRDLRLRYSNHGPYILKGLTFTIRGEEKIGIVGHTAAGKSSIVHALFRLAH-INGHISIDG 1105
            |::...:|::||..|.|.:|.|||.|..|..|.||||.|..|||:::..|||:.. ..|.|.|||
plant  1217 GEITICNLQVRYGPHLPMVLHGLTCTFPGGLKTGIVGRTGCGKSTLIQTLFRIVEPAAGEIRIDG 1281

  Fly  1106 FETSQLGLHDLRRRISIIPQDPVLFSGSLRFNLDPFEEKTDEELWLALEAVKLKEFVSNLKDGIN 1170
            .....:||||||.|:|||||||.:|.|::|.||||.||.||:::|.||:..:|.:.|...:..::
plant  1282 INILSIGLHDLRSRLSIIPQDPTMFEGTIRSNLDPLEEYTDDQIWEALDNCQLGDEVRKKELKLD 1346

  Fly  1171 CRLHDCGANFSMGQRQLVCLARALLRQNKILIMDEATANVDPETDNLIQEAIHTKFAHCTVLTIA 1235
            ..:.:.|.|:|:||||||||.|.||:::|:|::|||||::|..|||||||.:...||.|||:|||
plant  1347 SPVSENGQNWSVGQRQLVCLGRVLLKRSKLLVLDEATASIDTATDNLIQETLRHHFADCTVITIA 1411

  Fly  1236 HRLHTVMDNDRVMVVDMGRVVELGHPHELLHNRHGYLHRFV 1276
            ||:.:|:|:|.|:::|.|.:.|...|..||.:|.....:.|
plant  1412 HRISSVIDSDMVLLLDQGLIKEHDSPARLLEDRSSLFSKLV 1452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	408/1331 (31%)
		ABC_membrane	92..358	CDD:294371	57/289 (20%)
		ABCC_MRP_domain1	423..626	CDD:213217	84/202 (42%)
		ABC_membrane	762..988	CDD:294371	70/247 (28%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	105/219 (48%)
ABCC6	NP_187916.3	PLN03232	67..1452	CDD:215640	409/1339 (31%)
		ABC_membrane	286..555	CDD:294371	57/290 (20%)
		ABCC_MRP_domain1	601..801	CDD:213217	84/202 (42%)
		ABC_membrane	902..1173	CDD:294371	84/307 (27%)
		ABCC_MRP_domain2	1217..1437	CDD:213211	105/219 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720