DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and ABCC2

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_001189675.1	Gene:	ABCC2 / 818031	AraportID:	AT2G34660	Length:	1623	Species:	Arabidopsis thaliana

Alignment Length:	1362	Identity:	425/1362 - (31%)
Similarity:	678/1362 - (49%)	Gaps:	150/1362 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VHEQRQPNPVTKANFFSKWFFIWTREILVKGLQRNLDPSDLY------ETEPSLESTQVSSFLLG 62
            :.:.:|..|...||.|.|.||.|...::..|.:|.|...|::      :||....|.|.|
plant   219 ISDGQQICPEKHANIFDKIFFSWMNPLMTLGSKRPLTEKDVWYLDTWDQTETLFTSFQHS----- 278

  Fly    63 HWEQELKRSKPNVLRMIFKAYGWSFVPASIVYSIMAIAVHTTQPLMLGGLVSFFSESTGKITKHS 127
             |::||::.:|.:||.:..:.|..|..... :.|.........||:|..|:....|..   ....
plant   279 -WDKELQKPQPWLLRALNNSLGGRFWWGGF-WKIGNDCSQFVGPLLLNQLLKSMQEDA---PAWM 338

  Fly   128 AYLYA----MGVVLCSLISGLFFHPFMKYLFRVGSRVRLACAGLVYRKFLRVSVAADNSGVSGYA 188
            .|:||    :|||...|....:|...|    |||.|:|.|....|:||.||::........:|..
plant   339 GYIYAFSIFVGVVFGVLCEAQYFQNVM----RVGYRLRSALIAAVFRKSLRLTNEGRRKFQTGKI 399

  Fly   189 ISLMATDLPTFNESFYCFHELWRGPLEGVVFVYIIYQLIGWPAVVGLGTIVAFIPLQAWAARAIA 253
            .:||.||..:..:.....|.:|..|...::.:.::||.:|..:::|...:|...|||......:.
plant   400 TNLMTTDAESLQQICQSLHTMWSAPFRIIIALILLYQQLGVASLIGALLLVLMFPLQTVIISKMQ 464

  Fly   254 RYKRSSADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIRGSTYIYAGLQCTG 318
            :..:......|:|:.||||::|||..:|.||||.||...:..||.:|:...|.|..:  |.....
plant   465 KLTKEGLQRTDKRIGLMNEVLAAMDTVKCYAWENSFQSKVQTVRDDELSWFRKSQLL--GALNMF 527

  Fly   319 MISKLSLFLSLVTY-VFT---GDIV-----TSQKVFIVASYYDHLNDSLLHSWPLAINMWVETFV 374
            :::.:.:.:::|:: |||   ||:.     ||..:|.|..:       .|...|..|...|...|
plant   528 ILNSIPVLVTIVSFGVFTLLGGDLTPARAFTSLSLFAVLRF-------PLFMLPNIITQVVNANV 585

  Fly   375 VANRVKDFLFQHEN------PADGGVHNFKEAEDNPEHGNFFGRTHKPKAEVKSITVHKLSASWD 433
            ...|:::.|...|.      |.:.|                     :|     :|::.....|||
plant   586 SLKRLEEVLATEERILLPNPPIEPG---------------------EP-----AISIRNGYFSWD 624

  Fly   434 QKKQEKRHRHIEDVSFQAQDQQFVGIVGTVGAGKSTLLQVILGELDIISGS-VEVNGVLSYAPQE 497
            .|.....   :.:::........|.:||:.|.||::|:..|||||...|.: |.:.|.::|.||.
plant   625 SKGDRPT---LSNINLDVPLGSLVAVVGSTGEGKTSLISAILGELPATSDAIVTLRGSVAYVPQV 686

  Fly   498 PWLLRGSLRDNILFTEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLA 562
            .|:...::||||||..|:|.::|...:.|..|..|:|.||.||.|.:||.|.::|||||.|||:|
plant   687 SWIFNATVRDNILFGSPFDREKYERAIDVTSLKHDLELLPGGDLTEIGERGVNISGGQKQRVSMA 751

  Fly   563 RAVYRKADIYLLDDPLSAVDSHVSKMLLDRCLNEFLSKKIRILVTHRVQLLRHVDHLVLLEGGRI 627
            ||||..:|:|:.||||||:|:||.:.:.::|:...|.:|.|:|||:::..|..||.:||:..|.:
plant   752 RAVYSNSDVYIFDDPLSALDAHVGQQVFEKCIKRELGQKTRVLVTNQLHFLSQVDRIVLVHEGTV 816

  Fly   628 SVQGHYDALKK---LIRFRMSVANDVE--VAKLRAMRTDSVYEEP--------------EPRKSL 673
            ..:|.|:.|..   |.:..|..|..||  ..:......|...|:|              :.:||.
plant   817 KEEGTYEELSSNGPLFQRLMENAGKVEEYSEENGEAEADQTAEQPVANGNTNGLQMDGSDDKKSK 881

  Fly   674 SQEEHMDRHEIEQQFKEQQQIGSVKLQTYKEYFKVLGHPLVVVLILLMFVVARSSEATMDIFLSK 738
            ...:...:..:.:|  |:::.|.|..:..|.|...||...||:::||.:|:......|...:||:
plant   882 EGNKKGGKSVLIKQ--EERETGVVSWRVLKRYQDALGGAWVVMMLLLCYVLTEVFRVTSSTWLSE 944

  Fly   739 WATWEETEPNQHEPIPEYHRTRLRMMILYTFLILCTLIFYVLRTFGFFMMTLRISLRIHDQLFQG 803
            |.  :...|..|.|        |...::|..|....::..:..::...|.:|..:.::||.:...
plant   945 WT--DAGTPKSHGP--------LFYNLIYALLSFGQVLVTLTNSYWLIMSSLYAAKKLHDNMLHS 999

  Fly   804 VIRAFMHFFTLATSGRILNRFSSDV------LAIDVNLPQAMMDSIEFAVNALAVLAVVSTANIW 862
            ::||.|.||.....|||:|||:.|:      :|:.||:   .|..:...::.:.::.:|||.::|
plant  1000 ILRAPMSFFHTNPLGRIINRFAKDLGDIDRTVAVFVNM---FMGQVSQLLSTVVLIGIVSTLSLW 1061

  Fly   863 LLIPATVVVALLYGCRCLYIGASRSLKRIETISRSPIYSHTNATFKGLATIRA---------LNG 918
            .::|   ::.|.||....|...:|.:||:::|||||:|:.......||:||||         :||
plant  1062 AIMP---LLVLFYGAYLYYQNTAREVKRMDSISRSPVYAQFGEALNGLSTIRAYKAYDRMADING 1123

  Fly   919 TKYMERDFHYYQNENTSALYLHVSINRAFAFWTDLICVLYILAVTFSFLLFDKHRG----YYSGD 979
            ..         .:.|.....:::..||......:.:..|.|. :|.||.:....|.    .::..
plant  1124 RS---------MDNNIRFTLVNMGANRWLGIRLETLGGLMIW-LTASFAVMQNGRAENQQAFAST 1178

  Fly   980 VGLAITQSMKLVLMCQAGMRQTVELENMMTSVERVMEYVNIPSE--PAYETEESVNLPKHWPSGG 1042
            :||.::.::.:..:....:|.....||.:.:||||..|:.||.|  |..|....   |..|||.|
plant  1179 MGLLLSYALNITSLLTGVLRLASLAENSLNAVERVGNYIEIPPEAPPVIENNRP---PPGWPSSG 1240

  Fly  1043 QLDFRDLRLRYSNHGPYILKGLTFTIRGEEKIGIVGHTAAGKSSIVHALFRLAHI-NGHISIDGF 1106
            .:.|.|:.|||....|.:|.|::|.|...:|:||||.|.|||||:::||||:..: .|.|.||..
plant  1241 SIKFEDVVLRYRPQLPPVLHGVSFFIHPTDKVGIVGRTGAGKSSLLNALFRIVEVEKGRILIDDC 1305

  Fly  1107 ETSQLGLHDLRRRISIIPQDPVLFSGSLRFNLDPFEEKTDEELWLALEAVKLKEFVSNLKDGINC 1171
            :..:.||.|||:.:.||||.||||||::|||||||.|..|.:||.:||...||:.:.....|::.
plant  1306 DVGKFGLMDLRKVLGIIPQSPVLFSGTVRFNLDPFGEHNDADLWESLERAHLKDTIRRNPLGLDA 1370

  Fly  1172 RLHDCGANFSMGQRQLVCLARALLRQNKILIMDEATANVDPETDNLIQEAIHTKFAHCTVLTIAH 1236
            .:.:.|.|||:|||||:.|:|||||::|||::|||||.||..||.|||:.|..:|..||:|.|||
plant  1371 EVSEAGENFSVGQRQLLSLSRALLRRSKILVLDEATAAVDVRTDALIQKTIREEFKSCTMLIIAH 1435

  Fly  1237 RLHTVMDNDRVMVVDMGRVVELGHPHELLHNRHGYLHRFVEKTGVGTAQHLRHLAEQSYRKR 1298
            ||:|::|.|:::|:|.|||.|...|..||.|......:.|:.||...|::||.|...:.|.:
plant  1436 RLNTIIDCDKILVLDSGRVQEFSSPENLLSNEGSSFSKMVQSTGAANAEYLRSLVLDNKRAK 1497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	416/1325 (31%)
		ABC_membrane	92..358	CDD:294371	74/278 (27%)
		ABCC_MRP_domain1	423..626	CDD:213217	81/203 (40%)
		ABC_membrane	762..988	CDD:294371	59/244 (24%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	110/219 (50%)
ABCC2	NP_001189675.1	PLN03130	1..1623	CDD:215595	425/1362 (31%)
		ABC_membrane	309..570	CDD:279056	74/276 (27%)
		ABCC_MRP_domain1	614..815	CDD:213217	81/203 (40%)
		ABC_membrane	925..1179	CDD:294371	68/279 (24%)
		ABCC_MRP_domain2	1240..1460	CDD:213211	110/219 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	179	1.000	Domainoid score	I1056
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720