DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and Abcc6

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_112275.1	Gene:	Abcc6 / 81642	RGDID:	620268	Length:	1502	Species:	Rattus norvegicus

Alignment Length:	1362	Identity:	422/1362 - (30%)
Similarity:	666/1362 - (48%)	Gaps:	158/1362 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PNPVTKANFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLGHWEQELKRS--- 71
            |.|..:|:|.||..|.|...:|.||.::.|.|.||:    |||....|..|:...|:|.:|:
  Rat   208 PCPEAEASFPSKAMFWWASGLLWKGYRKLLGPKDLW----SLERENSSEELVSQLEREWRRNFSE 268

  Fly    72 -------------------KPN------VLRMIFKAYGWSFVPASIVYSIMAIAVHTTQPLMLGG 111
                               :|.      :||.|     |....::.:...:::.:.......:..
  Rat   269 LPGHKGHSGMGTPETEAFLQPERSQRGPLLRAI-----WRVFRSTFLLGTLSLVISDAFRFAVPK 328

  Fly   112 LVSFFSESTGKI--TKHSAYLYAMGVVLCSLISGLFFHPFMKYLFRV---GSRVRLACAGLVYRK 171
            |:|.|.|..|.:  :..:.:|.|:.:.|.:.:..||   ..:|::||   ..|:|.|..||||||
  Rat   329 LLSLFLEFMGDLESSAWTGWLLAVLMFLSACLQTLF---EQQYMYRVKVLQMRLRTAITGLVYRK 390

  Fly   172 FLRVSVAADNSGVSGYAISLMATDLPTFNESFYCFHELWRGPLEGVVFVYII------YQLIGWP 230
            .|.:|..:..|..:|..::|::.|:....||....:.||      ::|::||      :||:|..
  Rat   391 VLVLSSGSRKSSAAGDVVNLVSVDVQRLVESILHLNGLW------LLFLWIIVCFVYLWQLLGPS 449

  Fly   231 AVVGLGTIVAFIPLQAWAARAIARYKRSSADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGK 295
            |:..:...::.:||..:..:..:.::.........|.:|.:.::..::.||.:.||.:|.:.:..
  Rat   450 ALTAVAVFLSLLPLNFFITKKRSFHQEEQMRQKASRARLTSSMLRTVRTIKSHGWECAFLERLLH 514

  Fly   296 VRKEEMDSIRGSTYIYAGLQCTGMIS-KLSLFL-SLV-----TYVFTGDIVTSQKVFIVASYYDH 353
            :|.:|:.:::.|.::::    ..::| ::|.|| :||     |.|...:.:.::|.|:..:....
  Rat   515 IRGQELGALKTSAFLFS----VSLVSFQVSTFLVALVVFAVHTLVAEDNAMDAEKAFVTLTVLSI 575

  Fly   354 LNDSLLHSWPLAINMWVETFVVANRVKDFLFQHENPADGGVHNFKEAEDNPEHGNFFGRTHKPKA 418
            ||.:... .|.:::..|:..|..:|:..||...|...:|.|.:.........
  Rat   576 LNKAQAF-LPFSVHCLVQARVSFDRLAAFLCLEEVDPNGMVLSPSRCSSKDR------------- 626

  Fly   419 EVKSITVHKLSASWDQKKQEKRHRHIEDVSFQAQDQQFVGIVGTVGAGKSTLLQVILGELDIISG 483
                |::|..:.:|.|:.....|    .::........:.:||.||||||:||..:||||..:.|
  Rat   627 ----ISIHNGTFAWSQESPPCLH----GINLTVPQGCLLAVVGPVGAGKSSLLSALLGELLKVEG 683

  Fly   484 SVEVNGVLSYAPQEPWLLRGSLRDNILFTEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGG 548
            ||.:.|.::|.|||.|:...|:.:|:.|.:..|.....|||..|.|..||...|.|..|.|||.|
  Rat   684 SVSIEGSVAYVPQEAWVQNTSVVENVCFRQELDLPWLQEVLEACALGSDVASFPAGVHTPVGEQG 748

  Fly   549 ASLSGGQKARVSLARAVYRKADIYLLDDPLSAVDSHVSKMLLDRCL--NEFLSKKIRILVTHRVQ 611
            .:||||||.|:||||||||:|.:||:||||:|:|:|||:.:..:.:  :..|....||||||.:.
  Rat   749 MNLSGGQKQRLSLARAVYRRAAVYLMDDPLAALDAHVSQEVFKQVIGPSGLLQGTTRILVTHTLH 813

  Fly   612 LLRHVDHLVLLEGGRISVQGHYD-------ALKKLIRFRMSVANDVEVAKLRAMRTDSV------ 663
            :|...|.:::|..|.|:..|.|.       ||..|:......|.:.|.....|..:|.:
  Rat   814 VLPQADQILVLANGTIAEMGSYQDLLHRNGALVGLLDGARQPAGEGEGEAHAAATSDDLGGFSGG 878

  Fly   664 ------YEEPEP------RKSLSQ---EEHMDRHEIE--QQFKEQQQIGSVKLQTYKEYFKVLGH 711
                  .|.|.|      :.|.|:   |..:|..|:.  ...::..|.|.||..||..|.:.:|.
  Rat   879 GTPTRRPERPRPSDAAPVKGSTSEAQMEPSLDDVEVTGLTAGEDSVQYGRVKSATYLSYLRAVGT 943

  Fly   712 PLVVVLILLMFVVARSSEATMDIFLSKWATWEETEPNQHEPI---PEYHRTRLRMMILYTFLILC 773
            || ....|.:|:..:.:......:||.||         .:|:   .:.| :.||..|.  .|:.|
  Rat   944 PL-CTYTLFLFLCQQVASFCQGYWLSLWA---------DDPVVDGKQMH-SALRGSIF--GLLGC 995

  Fly   774 TLIFYVLRTFGF-------FMMTLRISLRIHDQLFQGVIRAFMHFFTLATSGRILNRFSSDVLAI 831
                  |:..|.       |:...|.|..:...|...|.|:.:.||.....|.:|||||.:...:
  Rat   996 ------LQAIGLFASMAAVFLGGARASCLLFRSLLWDVARSPIGFFERTPVGNLLNRFSKETDIV 1054

  Fly   832 DVNLPQAMMDSIEFAVNALAVLAVVSTANIWLLIPATVVVALLY-GCRCLYIGASRSLKRIETIS 895
            ||::|..|...:.:|...|.|...||.|.. |.|.|.:.:.||| |.:.||:.....|:|:|:.|
  Rat  1055 DVDIPDKMRTLLTYAFGLLEVGLAVSMATP-LAIVAILPLMLLYAGFQSLYVATCCQLRRLESAS 1118

  Fly   896 RSPIYSHTNATFKGLATIRALNGTKYMERDFHYYQNENTSALYLHVSINRAFAFWTDLICVLYIL 960
            .|.:.||...||:|...:||...............:||....:..:..:|..|...:|:....:.
  Rat  1119 YSSVCSHLAETFQGSQVVRAFQAQGPFTAQHDALMDENQRISFPRLVADRWLAANLELLGNGLVF 1183

  Fly   961 AVTFSFLLFDKHRGYYSGDVGLAITQSMKLVLMCQAGMRQTVELENMMTSVERVMEYVNIPSEPA 1025
            ......:|...|..  :|..|.:::.::::....|..:|...:|||.|.:||||.:||:.|.|..
  Rat  1184 VAATCAVLSKAHLS--AGLAGFSVSAALQVTQTLQWVVRSWTDLENSMVAVERVQDYVHTPKEAP 1246

  Fly  1026 YETEESVNLPKHWPSGGQLDFRDLRLRYSNHGPYILKGLTFTIRGEEKIGIVGHTAAGKSSIVHA 1090
            :....|...|. ||.|||::|||..||:....|..::|::..|...||:||||.|.|||||:...
  Rat  1247 WRLPSSAAQPL-WPCGGQIEFRDFGLRHRPELPMAVQGVSLKIHAGEKVGIVGRTGAGKSSLTWG 1310

  Fly  1091 LFRLAH-INGHISIDGFETSQLGLHDLRRRISIIPQDPVLFSGSLRFNLDPFEEKTDEELWLALE 1154
            |.||.. ..|.|.|||...:.:|||.||.||:|||||||||.||||.|||..:|.|||.:|.|||
  Rat  1311 LLRLQEATEGGIWIDGVPITDMGLHTLRSRITIIPQDPVLFPGSLRMNLDLLQENTDEGIWAALE 1375

  Fly  1155 AVKLKEFVSNLKDGINCRLHDCGANFSMGQRQLVCLARALLRQNKILIMDEATANVDPETDNLIQ 1219
            .|:||.||::|...:.......|.:.|:||:||:||||||||:.:|||:|||||:|||.|:..:|
  Rat  1376 TVQLKAFVTSLPGQLQYECSGQGDDLSVGQKQLLCLARALLRKTQILILDEATASVDPGTEIQMQ 1440

  Fly  1220 EAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGRVVELGHPHELLHNRHGYLHRFVEKTGV 1281
            .|:...||.||||.|||||.:||:..||:|:|.|:|.|.|.|.:||..: |..:|..:::|:
  Rat  1441 AALERWFAQCTVLLIAHRLRSVMNCARVLVMDEGQVAESGSPAQLLAQK-GLFYRLAQESGL 1501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	419/1347 (31%)
		ABC_membrane	92..358	CDD:294371	63/283 (22%)
		ABCC_MRP_domain1	423..626	CDD:213217	83/204 (41%)
		ABC_membrane	762..988	CDD:294371	60/233 (26%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	116/219 (53%)
Abcc6	NP_112275.1	MRP_assoc_pro	36..1501	CDD:188098	421/1360 (31%)
		ABC_membrane	313..577	CDD:294371	61/276 (22%)
		ABCC_MRP_domain1	627..828	CDD:213217	83/204 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	854..909		10/54 (19%)
		ABC_membrane	950..1215	CDD:294371	69/285 (24%)
		ABCC_MRP_domain2	1262..1482	CDD:213211	116/219 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345095
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.650