DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and ABCC13

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_001323940.1	Gene:	ABCC13 / 815414	AraportID:	AT2G07680	Length:	1426	Species:	Arabidopsis thaliana

Alignment Length:	1301	Identity:	408/1301 - (31%)
Similarity:	667/1301 - (51%)	Gaps:	119/1301 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 WFFIWT----REILVKGLQRNLDPSDLYETEPSLESTQVSSFLLGHWE-QELKR-SKPNVLRMIF 80
            |:.::|    ..|:..|..:.|:..:|....|.::.......||..|: ||... |.|:::..|:
plant   195 WWDLFTFGYIGSIMKHGSVKQLELENLLTLPPEMDPFTCCENLLRCWQLQECNNYSTPSLIWSIY 259

  Fly    81 KAYGWSFVPASIVYSIMAIAVHTTQPLMLGGLVSFFSESTGKITKHSAYLYAMGVVLCSLISGLF 145
            ..|||.:....:: .:....:....||:|..|:.:..:.:|     |:..|.:.:.| ..||  .
plant   260 GVYGWPYFRLGLL-KVFNDCIGFAGPLLLNRLIKYLEKGSG-----SSVGYTLAISL-GFIS--I 315

  Fly   146 FHPFM--KYLFRVGS---RVRLACAGLVYRKFLRVSVAADNSGVS-GYAISLMATDLPTFNESFY 204
            |..|:  :|.||:..   ::|.:...::|||.|.|: .|:.||.| |...:.|:.|.........
plant   316 FKSFLDTQYTFRLSKLKLKLRSSIMSVIYRKCLWVN-TANRSGFSEGEIQTFMSVDADRIVNLCN 379

  Fly   205 CFHELWRGPLEGVVFVYIIYQLIGWPAVVGLGTIVAFIPLQAWAARAIARYKRSSADVGDERVKL 269
            ..|:||..||:..:.:|::|..:.:..:.||...:..||:..|.:..||........:.|||::.
plant   380 SLHDLWSLPLQIGIALYLLYTQVKFAFLSGLAITILLIPVNKWISVLIASATEKMMKLKDERIRK 444

  Fly   270 MNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIRGSTYIYAGLQCTGMISKLSLFLSLVT--- 331
            ..|::..::.:|||.|:..||..:.:.|..|:..:  :|..|....|....:......||.|
plant   445 TGELLTNIRTLKMYGWDNWFADWLKETRATEVTHL--ATRKYLDAWCVFFWATTPTLFSLCTFGL 507

  Fly   332 YVFTGDIVTSQKVFIVASYYDHLNDSLLHSWPLAINMWVETFVVANRVKDFLFQHENPADGGVHN 396
            :...|..:.:..||...:.::.| .|.|:|:|..||..::.|:...||..||...|:..|..:.:
plant   508 FALMGHQLDAATVFTCLALFNSL-ISPLNSFPWVINGLIDAFISTRRVSKFLCCLEHSRDFSIDS 571

  Fly   397 FKEAEDNPEHGNFFGRTHKPKAEVKSITVHKLSASWDQKKQEKRHRHIEDVSFQAQDQQFVGIVG 461
            ...:||                  .::.|...|.:|....:|..:..|:.||.:.....||.::|
plant   572 GFTSED------------------LAVCVEDASCTWSSNVEEDYNLTIKQVSLRVPKGSFVAVIG 618

  Fly   462 TVGAGKSTLLQVILGELDIISGSVEVNGVLSYAPQEPWLLRGSLRDNILFTEPYDEQRYLEVLRV 526
            .||:||::||..:|||:..:.||:.:||.::|.||.||||.|::|:||||.:|:|.:||.|.|..
plant   619 EVGSGKTSLLNSLLGEMRCVHGSILLNGSVAYVPQVPWLLSGTVRENILFGKPFDSKRYFETLSA 683

  Fly   527 CHLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLARAVYRKADIYLLDDPLSAVDSHVSKMLLD 591
            |.||.|:..:..||...:|:.|.:|||||:||.:||||||..:|:|||||.||||||.|...:|.
plant   684 CALDVDISLMVGGDMACIGDKGLNLSGGQRARFALARAVYHGSDMYLLDDVLSAVDSQVGCWILQ 748

  Fly   592 RC-LNEFLSKKIRILVTHRVQLLRHVDHLVLLEGGRISVQGHYDALKKLIRFRMSVANDVEVAKL 655
            |. |...|:||.|::.||.:|.:...|.:|:::.|:::..|....:.|.|....|:.|:.:::
plant   749 RALLGPLLNKKTRVMCTHNIQAISCADMIVVMDKGKVNWSGSVTDMPKSISPTFSLTNEFDMS-- 811

  Fly   656 RAMRTDSVYEEPEPRKSLS-QEEHMDRHEIEQQFK-----EQQQIGSVKLQTYKEYFKVLGHPLV 714
                  |.....:.:::|| :|:.:|  ||.:...     |:::.|.|::..|:.| .|.....:
plant   812 ------SPNHLTKRKETLSIKEDGVD--EISEAAADIVKLEERKEGRVEMMVYRNY-AVFSGWFI 867

  Fly   715 VVLILLMFVVARSSEATMDIFLSKWATWEETEPNQHEPIPEYHRTRLRMMILYTFLILCTLIFYV 779
            .::||:..|:.:.|....|::||.|.  ::|...     ..::.|...:|:|..|.|:.:::..|
plant   868 TIVILVSAVLMQGSRNGNDLWLSYWV--DKTGKG-----VSHYSTSFYLMVLCIFCIINSILTLV 925

  Fly   780 LRTFGFFMMTLRISLRIHDQLFQGVIRAFMHFFTLATSGRILNRFSSDVLAIDVNLPQAMMDSIE 844
             |.|.|....|:.::.:|:.|...:|.|...||....|||||||||||:..||        ||:.
plant   926 -RAFSFAFGGLKAAVHVHNALISKLINAPTQFFDQTPSGRILNRFSSDLYTID--------DSLP 981

  Fly   845 FAVNAL-----------AVLAVVSTANIWLLIPATVVVALLYGCRCLYIGASRSLKRIETISRSP 898
            |.:|.|           .||:.|....:.||:|...:.:.|   :..|...||.|:|::::||||
plant   982 FILNILLANFVGLLGIIVVLSYVQVLFLLLLLPFWYIYSKL---QVFYRSTSRELRRLDSVSRSP 1043

  Fly   899 IYSHTNATFKGLATIRALNGTKYMERDF--HYYQNENTSALYLHVSINRAFA-FWTDL------- 953
            ||:....|..|.:||||....::....|  |.       .||...|.:...| .|..|
plant  1044 IYASFTETLDGSSTIRAFKSEEHFVGRFIEHL-------TLYQRTSYSEIIASLWLSLRLQLLGS 1101

  Fly   954 ICVLY--ILAVTFSFLLFDKHRGYYSGDVGLAITQSMKLVLMCQAGMRQTVELENMMTSVERVME 1016
            :.||:  ::||..|...|....| ..|.||||::.:..||.:..:.:....|.|..|.|||||::
plant  1102 MIVLFVAVMAVLGSGGNFPISFG-TPGLVGLALSYAAPLVSLLGSLLTSFTETEKEMVSVERVLQ 1165

  Fly  1017 YVNIPSEPAYETEESVNLPKHWPSGGQLDFRDLRLRYSNHGPYILKGLTFTIRGEEKIGIVGHTA 1081
            |:::|.|   |.....:|...||..|.::|.::.:||.:..|..|..::|||:|...:|::|.|.
plant  1166 YMDVPQE---EVSGPQSLSDKWPVHGLVEFHNVTMRYISTLPPALTQISFTIQGGMHVGVIGRTG 1227

  Fly  1082 AGKSSIVHALFRLAHI-NGHISIDGFETSQLGLHDLRRRISIIPQDPVLFSGSLRFNLDPFEEKT 1145
            ||||||::|||||..: :|.|.:||...|.|.:.:||..::::||.|.||.||||.||||.....
plant  1228 AGKSSILNALFRLTPVCSGEILVDGKNISHLPIRELRSCLAVVPQSPFLFQGSLRDNLDPLGLSE 1292

  Fly  1146 DEELWLALEAVKLKEFVSNLKDGINCRLHDCGANFSMGQRQLVCLARALLRQNKILIMDEATANV 1210
            |..:|..|:..|:|..|.:: .|::..:.:.|.:||:|||||:|||||||:.:|||.:||.|||:
plant  1293 DWRIWEILDKCKVKAAVESV-GGLDSYVKESGCSFSVGQRQLLCLARALLKSSKILCLDECTANI 1356

  Fly  1211 DPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGRVVELGHPHELLHNRHGYLHRF 1275
            |..|.:|:...|.::....||:|||||:.||:|.|.::::|.|.:||.|.|..||.:.......|
plant  1357 DVHTASLLHNTISSECKGVTVITIAHRISTVVDLDSILILDRGILVEQGKPQHLLQDDSSTFSSF 1421

  Fly  1276 V 1276
            |
plant  1422 V 1422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	406/1291 (31%)
		ABC_membrane	92..358	CDD:294371	64/274 (23%)
		ABCC_MRP_domain1	423..626	CDD:213217	88/203 (43%)
		ABC_membrane	762..988	CDD:294371	77/248 (31%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	95/219 (43%)
ABCC13	NP_001323940.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	50	1.000	Domainoid score	I4365
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720