DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and Abcc3

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_001350116.1	Gene:	Abcc3 / 76408	MGIID:	1923658	Length:	1523	Species:	Mus musculus

Alignment Length:	1360	Identity:	440/1360 - (32%)
Similarity:	704/1360 - (51%)	Gaps:	162/1360 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PNPVTKANFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLGHWEQEL------ 68
            |.|...|.|||:..|.|...:.:.|.:|.|:..||:.......|.:|...||..|:::.
Mouse   206 PCPEASAGFFSRLSFWWFTRLAILGYRRPLEDRDLWSLSEEDCSHKVVQRLLEAWQKQQNQASRS 270

  Fly    69 ---------------------KRSKPNVLRMIFKAYGWSFVPASIVYSIMAIAVHTTQPLMLGGL 112
                                 |..:|:.||.:.:.:..|.: .|..::::...:....|.:|..|
Mouse   271 QTATAEPKIPGEDAVLLKPRPKSKQPSFLRALVRTFTSSLL-MSACFNLIQNLLGFVNPQLLSIL 334

  Fly   113 VSFFSESTGKITKHSAYLYAMGVVLCSLISGLFFHPFMKYLFRVGSRVRLACAGLVYRKFLRVSV 177
            :.|.|:.|.  .....:|.|..:.|.|.:..|..|.:...:|.:..|:|.|..|::|||.|.::.
Mouse   335 IRFISDPTA--PTWWGFLLAGLMFLSSTMQTLILHQYYHCIFVMALRLRTAIIGVIYRKALVITN 397

  Fly   178 AADNSGVSGYAISLMATDLPTFNESFYCFHELWRGPLEGVVFVYIIYQLIGWPAVVGLGTIVAFI 242
            :.......|..::||:.|...|.:.....:.||..||:.::.:|.::|::|..|:.|:..||..|
Mouse   398 SVKRESTVGEMVNLMSVDAQRFMDVSPFINLLWSAPLQVILAIYFLWQILGPSALAGVAVIVLLI 462

  Fly   243 PLQAWAARAIARYKRSSADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIRGS 307
            ||....:..:..|:.......|.|:|||:||:..::::|:||||.||.:.:..:|:.|:..:|..
Mouse   463 PLNGAVSMKMKTYQVKQMKFKDSRIKLMSEILNGIKVLKLYAWEPSFLEQVKGIRQSELQLLRKG 527

  Fly   308 TYIYAGLQ----CTGMISKLSLFLSLVTYVFTGDIVTSQKVFIVASYYDHLNDSLLHSWPLAINM 368
            .|:.|...    ||..:..| :.|.:..||...:::.::|.|:..|.::.|... |:..|..|:.
Mouse   528 AYLQAISTFIWICTPFLVTL-ITLGVYVYVDESNVLDAEKAFVSLSLFNILKIP-LNMLPQLISG 590

  Fly   369 WVETFVVANRVKDFLFQHE-NPADGGVHNFKEAEDNPEHGNFFGRTHKPKAEVKSITVHKLSASW 432
            ..:..|...|::|||.|:| :|     ...:....:|.:               :||:|..:.:|
Mouse   591 LTQASVSLKRIQDFLNQNELDP-----QCVERKTISPGY---------------AITIHNGTFTW 635

  Fly   433 DQKKQEKRHRHIEDVSFQAQDQQFVGIVGTVGAGKSTLLQVILGELDIISGSVEVNGVLSYAPQE 497
            .|......|    .::.|......|.:||.||.|||:|:..:|||::.:.|.|.|.|.::|.||:
Mouse   636 AQDLPPTLH----SLNIQIPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGVVSVKGSVAYVPQQ 696

  Fly   498 PWLLRGSLRDNILFTEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLA 562
            .|:...:|::|:||.:|.:.:||.:.|..|.|..|::.||.||.|.:||.|.:|||||:.|||||
Mouse   697 AWIQNCTLQENVLFGQPMNPKRYQQALETCALLADLDVLPGGDQTEIGEKGINLSGGQRQRVSLA 761

  Fly   563 RAVYRKADIYLLDDPLSAVDSHVSKMLLDRCLNE--FLSKKIRILVTHRVQLLRHVDHLVLLEGG 625
            ||||..|:|:|||||||||||||:|.:.|:.:..  .|:.|.|:||||.:..|...|.:::|.||
Mouse   762 RAVYSDANIFLLDDPLSAVDSHVAKHIFDQVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLAGG 826

  Fly   626 RISVQGHYDALKKLIRFRMSVAN------------DVEVAKLRA------------MRTDSVYEE 666
            ::|..|||.|   |::...|.||            |.|.|...|            ..||....|
Mouse   827 QVSEMGHYSA---LLQHDGSFANFLRNYAPDEDQEDHEAALQNANEEVLLLEDTLSTHTDLTDNE 888

  Fly   667 P---EPRK-------SLSQEEHMDR--------HEIEQQ------------FKEQ-QQIGSVKLQ 700
            |   |.||       |||.|..:..        :.:|::            .||: .:.|:|||.
Mouse   889 PAIYEVRKQFMREMSSLSSEGEVQNRTMPKKHTNSLEKEALVTKTKETGALIKEEIAETGNVKLS 953

  Fly   701 TYKEYFKVLGHPLVVVLILLMFVVARSSEAT-MDIFLSKWATWEETEPNQHEPIPEYHRTRLRMM 764
            .|.:|.|.:|  |...|.:.:....:|:.|. .:::||.|:       |..|...:.::|.:|:.
Mouse   954 VYWDYAKSMG--LCTTLSICLLYGGQSAAAIGANVWLSAWS-------NDAEEHGQQNKTSVRLG 1009

  Fly   765 ILYTFLILCTLIFYVLRTFGFFMMTLRISLRIHDQLFQGVIRAFMHFFTLATSGRILNRFSSDVL 829
            : |..|.:...:..:|..|...:..::.:..:|:.|....||:...||....|||||||||.|:.
Mouse  1010 V-YAALGILQGLLVMLSAFTMVVGAIQAARLLHEALLHNKIRSPQSFFDTTPSGRILNRFSKDIY 1073

  Fly   830 AID-VNLPQAMMDSIEFAVNALAVLAVVSTANIWLLIPATVVVALLYG-CRCLYIGASRSLKRIE 892
            .|| |..|..:|....|..:...::.:|::..:::::  .:.:|:||| .:..|:..||.|||:|
Mouse  1074 VIDEVLAPTILMLLNSFFTSISTIMVIVASTPLFMVV--VLPLAVLYGFVQRFYVATSRQLKRLE 1136

  Fly   893 TISRSPIYSHTNATFKGLATIRA---------LNGTKYMERDFHYYQNENTSALYLHVSINRAFA 948
            :||||||:||.:.|..|.:.|||         |:.||.         :.|..:.|.:::.||...
Mouse  1137 SISRSPIFSHFSETVTGTSVIRAYGRIQDFKVLSDTKV---------DNNQKSSYPYIASNRWLG 1192

  Fly   949 FWTDLI--CVLYILAVTFSFLLFDKHRGYYSGDVGLAITQSMKLVLMCQAGMRQTVELENMMTSV 1011
            ...:.:  ||: :.|..|:.:   .......|.|||:::.::::.:.....:|...:||:.:.:|
Mouse  1193 VHVEFVGNCVV-LFAALFAVI---GRNSLNPGLVGLSVSYALQVTMALNWMIRMISDLESNIIAV 1253

  Fly  1012 ERVMEYVNIPSEPAYETEESVNLPKHWPSGGQLDFRDLRLRYSNHGPYILKGLTFTIRGEEKIGI 1076
            |||.||....:|..: ..||...|:.||:.|.::||:..:||......:||.:|..::|.||:||
Mouse  1254 ERVKEYSKTKTEAPW-VVESNRAPEGWPTRGMVEFRNYSVRYRPGLELVLKNVTVHVQGGEKVGI 1317

  Fly  1077 VGHTAAGKSSIVHALFR-LAHINGHISIDGFETSQLGLHDLRRRISIIPQDPVLFSGSLRFNLDP 1140
            ||.|.|||||:...||| |....|.|.|||...:.:||||||.:::||||||:||||:||.||||
Mouse  1318 VGRTGAGKSSMTLCLFRILEAAEGEIVIDGLNVAHIGLHDLRSQLTIIPQDPILFSGTLRMNLDP 1382

  Fly  1141 FEEKTDEELWLALEAVKLKEFVSNLKDGINCRLHDCGANFSMGQRQLVCLARALLRQNKILIMDE 1205
            |...::|::|.|||...|..|||:...|::.:..:.|.|.|:||||||||||||||::::|::||
Mouse  1383 FGRYSEEDIWRALELSHLNTFVSSQPAGLDFQCAEGGDNLSVGQRQLVCLARALLRKSRVLVLDE 1447

  Fly  1206 ATANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGRVVELGHPHELL 1265
            |||.:|.|||:|||..|.|:|..||||||||||:|:||.:||:|:|.|.|.|...|..|:
Mouse  1448 ATAAIDLETDDLIQGTIRTQFEDCTVLTIAHRLNTIMDYNRVLVLDKGVVAEFDSPVNLI 1507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	440/1360 (32%)
		ABC_membrane	92..358	CDD:294371	70/269 (26%)
		ABCC_MRP_domain1	423..626	CDD:213217	88/204 (43%)
		ABC_membrane	762..988	CDD:294371	67/238 (28%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	116/219 (53%)
Abcc3	NP_001350116.1	MRP_assoc_pro	7..1522	CDD:188098	440/1360 (32%)
Abcc3	NP_001350116.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	903..923		4/19 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841639
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.650