Protein Alignment CG11898 and TAP1

DIOPT Version :9

• Sequence 1: NP_651679.2
• Gene: CG11898 / 43451
• FlyBaseID: FBgn0039645
• Length: 1320
• Species: Drosophila melanogaster
• Sequence 2: NP_000584.3
• Gene: TAP1 / 6890
• HGNCID: 43
• Length: 748
• Species: Homo sapiens
• Alignment Length: 608
• Identity: 137/608 - (22%)
• Similarity: 256/608 - (42%)
• Gaps: 116/608 - (19%)

  Fly   717 LILLMFVVARSSEATMDIFLSKWATWEETEPNQHEPIPEYHRTRLRMMILYTFLILCTLIFYVLR 781
            |.|::.|::...|..:..|..:...|...:.:..        |..|.:.|.:.|.:.:.:...:.
Human   189 LFLVLVVLSSLGEMAIPFFTGRLTDWILQDGSAD--------TFTRNLTLMSILTIASAVLEFVG 245

  Fly   782 TFGFFMMTL-RISLRIHDQLFQGVIRAFMHFFTLATSGRILNRFSSDVLAIDVNLPQAMMDSIEF 845
            . |.:..|: .:...:..::|..|:|....||....:|.|::|.:.|...:..:|.:.:...:.:
Human   246 D-GIYNNTMGHVHSHLQGEVFGAVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSLFLWY 309

  Fly   846 AVNALAVLAVVSTANIWLLIPATVVVALLY--------GCRCLYIGASRSLKR-----IETISRS 897
            .|..|.:|.::...::.|.:...:.:.||:        ..:.|.:....||.:     ||.:|..
Human   310 LVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAM 374

  Fly   898 P-IYSHTNATFKG------LATIRALNGTKYMERDFHYYQNENTSALYLHVSINRAFAFWTDLIC 955
            | :.|..|...:.      |..|:.||            |.|         ::..|...||..|.
Human   375 PTVRSFANEEGEAQKFREKLQEIKTLN------------QKE---------AVAYAVNSWTTSIS 418

  Fly   956 -------VLYI--LAVT---------FSFLLFDKHRGYYSGDVGLAITQSMKLVLMCQAGMRQTV 1002
                   :|||  ..||         .:|:|:.           :..||:::::|.....:::.|
Human   419 GMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQ-----------MQFTQAVEVLLSIYPRVQKAV 472

  Fly  1003 ELENMMTSVERVMEYVNIPSEPAYETEESVNLPKHWPSG--------GQLDFRDLRLRYSNH-GP 1058
                  .|.|::.||::             ..|:..|||        |.:.|:|:...|.|. ..
Human   473 ------GSSEKIFEYLD-------------RTPRCPPSGLLTPLHLEGLVQFQDVSFAYPNRPDV 518

  Fly  1059 YILKGLTFTIRGEEKIGIVGHTAAGKSSIVHALFRLAH-INGHISIDGFETSQLGLHDLRRRISI 1122
            .:|:|||||:|..|...:||...:|||::...|..|.. ..|.:.:||....|.....|.|:::.
Human   519 LVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVAA 583

  Fly  1123 IPQDPVLFSGSLRFNL--DPFEEKTDEELWLALEAVKLKEFVSNLKDGINCRLHDCGANFSMGQR 1185
            :.|:|.:|..||:.|:  ...::.|.||:..|........|:|.|..|.:..:.:.|:..|.|||
Human   584 VGQEPQVFGRSLQENIAYGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQR 648

  Fly  1186 QLVCLARALLRQNKILIMDEATANVDPETDNLIQEAIH---TKFAHCTVLTIAHRLHTVMDNDRV 1247
            |.|.|||||:|:..:||:|:||:.:|..:...:::.::   .:::. :||.|...|..|...|.:
Human   649 QAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSR-SVLLITQHLSLVEQADHI 712

  Fly  1248 MVVDMGRVVELGHPHELLHNRHG 1270
            :.::.|.:.| |..|:.|..:.|
Human   713 LFLEGGAIRE-GGTHQQLMEKKG 734

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	136/604 (23%)
		ABC_membrane	92..358	CDD:294371
		ABCC_MRP_domain1	423..626	CDD:213217
		ABC_membrane	762..988	CDD:294371	49/264 (19%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	68/225 (30%)
TAP1	NP_000584.3	3a01208	18..740	CDD:273363	137/608 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910