DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and ABCC8

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	XP_016873686.1	Gene:	ABCC8 / 6833	HGNCID:	59	Length:	1604	Species:	Homo sapiens

Alignment Length:	1413	Identity:	400/1413 - (28%)
Similarity:	671/1413 - (47%)	Gaps:	188/1413 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 NFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLGHWEQELKRSKPNV--LRMI 79
            |..||..:.|....:....::.:|...:.:...::.:......|...::.::::.....  .|.|
Human   223 NLLSKGTYWWMNAFIKTAHKKPIDLRAIGKLPIAMRALTNYQRLCEAFDAQVRKDIQGTQGARAI 287

  Fly    80 FKAYGWSF---VPASIVYSIMAIAVHTTQPLMLGGLVS------------------FFSESTGKI 123
            ::|...:|   :..|..:.|:|..:....||.:.|:|.                  :|..|...:
Human   288 WQALSHAFGRRLVLSSTFRILADLLGFAGPLCIFGIVDHLGKENDVFQPKTQFLGVYFVSSQEFL 352

  Fly   124 TKHSAYLYAMGVVLCSLISGLFFHPFMKYLFRVGSRVRLACAGLVYRKFLRVSVAADNSG--VSG 186
            .  :||:.|:.:.|..|:...|...........|..:|.|....:|.|.:.:|.:..:.|  .:|
Human   353 A--NAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAG 415

  Fly   187 YAISLMATDLPTFNESFYCFHELWRGPLEGVVFVYIIYQLIGWPAVVGLGTIVAFIPLQAWAARA 251
            ...:|:|.|.......|:....||..|::.:|.|.::|.::|..|::|...|:...|:|.:.|..
Human   416 QICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATK 480

  Fly   252 IARYKRSSADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIRGSTYIYAGLQC 316
            :::.:||:.:..:||:|..||::..::|:|:||||..|...:...|::||.|:|... ||
Human   481 LSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAFA-IY----- 539

  Fly   317 TGMISKLSLFLS--------LVTYV----FTGDIVTSQKVFIVASYYDHLNDSLLHSWPLAINMW 369
                :.:|:|::        |:|:|    |..:...|..|...:....|:..:.|......:...
Human   540 ----TSISIFMNTAIPIAAVLITFVGHVSFFKEADFSPSVAFASLSLFHILVTPLFLLSSVVRST 600

  Fly   370 VETFVVANRVKDFLFQ----------HENPADGGVHNFKEAED-----------------NPEHG 407
            |:..|...::.:||..          ||....|....::..|:                 :|:..
Human   601 VKALVSVQKLSEFLSSAEIREEQCAPHEPTPQGPASKYQAVEEGLPSLHSSQPSGSSPPNHPQPL 665

  Fly   408 NFFGRTHKPKAEVKSIT--VHKLSASWDQKKQE--------------KRHRHIEDVSFQAQDQQF 456
            ....|....:.:.:.:|  :..|..|.|.....              .....:.:::.:....|.
Human   666 RVVNRKRPAREDCRGLTGPLQSLVPSADGDADNCCVQIMGGYFTWTPDGIPTLSNITIRIPRGQL 730

  Fly   457 VGIVGTVGAGKSTLLQVILGELDIISGSV---------EV------------------NGVLSYA 494
            ..|||.||.|||:||...|||:..:||:|         |:                  .|.::||
Human   731 TMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSSLPDSEIGEDPSPERETATDLDIRKRGPVAYA 795

  Fly   495 PQEPWLLRGSLRDNILFTEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARV 559
            .|:||||..::.:||:|..|:::|||..|:..|.|..|::.||.||.|::||.|.:|||||:.|:
Human   796 SQKPWLLNATVEENIIFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRI 860

  Fly   560 SLARAVYRKADIYLLDDPLSAVDSHVSKMLLDRCLNEFL--SKKIRILVTHRVQLLRHVDHLVLL 622
            |:|||:|:.|::..||||.||:|.|:|..|:...:.|.|  .|:..:||||::|.|.|.|.::.:
Human   861 SVARALYQHANVVFLDDPFSALDIHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAM 925

  Fly   623 EGGRISVQGHYDALKKLIRFRMSVANDVEVAKLRAMRTDSVYEE--------PEPRKSLS----- 674
            :.|.|..:|   .||.   |:.|.....|..|....|.|...|:        .||.:.||
Human   926 KDGTIQREG---TLKD---FQRSECQLFEHWKTLMNRQDQELEKETVTERKATEPPQGLSRAMSS 984

  Fly   675 -----QEEHMDRHEIEQQFKEQQQIGSVKLQ----TYKEYFKVLGHPLVVVLILLMF--VVARSS 728
                 |:|..:..|..:. :|...:.|:..|    .::...|.|....:::|.||:|  ::....
Human   985 RDGLLQDEEEEEEEAAES-EEDDNLSSMLHQRAEIPWRACAKYLSSAGILLLSLLVFSQLLKHMV 1048

  Fly   729 EATMDIFLSKWATWEET-EPNQHEPIPEYHRTRLRMMILYTFLILCTL--IFYVLRTFGFFMMTL 790
            ...:|.:|:||.....| .|...........|..:.:....|.:||:|  :..::.:.......|
Human  1049 LVAIDYWLAKWTDSALTLTPAARNCSLSQECTLDQTVYAMVFTVLCSLGIVLCLVTSVTVEWTGL 1113

  Fly   791 RISLRIHDQLFQGVIRAFMHFFTLATSGRILNRFSSDVLAIDVNLP---QAMMDSIEFAVNALAV 852
            :::.|:|..|...:|.|.|.||.....|.||||||||...||.::|   :.:..|....|:||||
Human  1114 KVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALAV 1178

  Fly   853 LAVVSTANIWLLIPATVVVALLYGCRCLYIG-----ASRSLKRIETISRSPIYSHTNATFKGLAT 912
            ::.|:...:..|:|..:|        |.:|.     |||.|::::..::.|:.||...|.:||.|
Human  1179 ISYVTPVFLVALLPLAIV--------CYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTT 1235

  Fly   913 IRALN-GTKYMERDFHYYQNENTSALYLHVSINRAFAFWTDL------ICVLYILAVTFSFLLFD 970
            |||.. ..::.::...|..:.|.::|:| .:.||    |.::      .||:.|.|||  .:...
Human  1236 IRAFRYEARFQQKLLEYTDSNNIASLFL-TAANR----WLEVRMEYIGACVVLIAAVT--SISNS 1293

  Fly   971 KHRGYYSGDVGLAITQSMKLVLMCQAGMRQTVELENMMTSVERVMEYVNIPSEPAYETEESVNL- 1034
            .||...:|.|||.:|.::.:.......:|...::|..:.:|:|:...:...:| :||...:.:|
Human  1294 LHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLLKTEAE-SYEGLLAPSLI 1357

  Fly  1035 PKHWPSGGQLDFRDLRLRYSNHGPYILKGLTFTIRGEEKIGIVGHTAAGKSSIVHALFRLAH-IN 1098
            ||:||..|::..::|.:||.:....:||.:...|...:||||.|.|.:||||...|.||:.. ..
Human  1358 PKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFE 1422

  Fly  1099 GHISIDGFETSQLGLHDLRRRISIIPQDPVLFSGSLRFNLDPFEEKTDEELWLALEAVKLKEFVS 1163
            |||.|||.:.::|.||.||.|:|||.||||||||::||||||..:.:|..||.|||..:||..|.
Human  1423 GHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLWEALEIAQLKLVVK 1487

  Fly  1164 NLKDGINCRLHDCGANFSMGQRQLVCLARALLRQNKILIMDEATANVDPETDNLIQEAIHTKFAH 1228
            .|..|::..:.:.|.|||.|||||.|||||.:|:..|.|||||||::|..|:|::|:.:.|.||.
Human  1488 ALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFAD 1552

  Fly  1229 CTVLTIAHRLHTVMDNDRVMVVDMGRVVELGHPHELLHNRHGYLHRFV 1276
            .||:|||||:||::..|.|:|:..|.::|...|.:||..:......||
Human  1553 RTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRKDSVFASFV 1600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	398/1403 (28%)
		ABC_membrane	92..358	CDD:294371	69/297 (23%)
		ABCC_MRP_domain1	423..626	CDD:213217	82/247 (33%)
		ABC_membrane	762..988	CDD:294371	71/242 (29%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	104/219 (47%)
ABCC8	XP_016873686.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151571
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.650