DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and Abcb9

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_063928.2	Gene:	Abcb9 / 56325	MGIID:	1861729	Length:	762	Species:	Mus musculus

Alignment Length:	664	Identity:	165/664 - (24%)
Similarity:	283/664 - (42%)	Gaps:	144/664 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   692 QQIGSVKLQTYKEYFKVLGHPLVVVLILLMF--VVARSSEATMDIFLSKWATWEETEPNQHEPIP 754
            :|.....||....|.|    |.|..|:...|  :||...|.    ||                 |
Mouse   163 EQASGATLQKLLSYTK----PDVAFLVAASFFLIVAALGET----FL-----------------P 202

  Fly   755 EYHRTRLRMMILY--------TFLILCTLIFYVLRTFG-----FFMMTLRISLRIHDQLFQGVIR 806
            .|....:..:::.        ..:::|.|........|     |.::..|:::|:.:.||:.::.
Mouse   203 YYTGRAIDSIVIQKSMDQFTTAVVVVCLLAIGSSLAAGIRGGIFTLVFARLNIRLRNCLFRSLVS 267

  Fly   807 AFMHFFTLATSGRILNRFSSDVLAI------DVNLPQAMMDSIEFAVNALAVLAVV--STANIWL 863
            ....||....:|.:::|.:||...:      ::|:         |..|.:.|..||  ..:..|.
Mouse   268 QETSFFDENRTGDLISRLTSDTTMVSDLVSQNINI---------FLRNTVKVTGVVVFMFSLSWQ 323

  Fly   864 L-------IPATVVVALLYGCRCLYIGASRSLKRIETISRSPI-YSHTNA--TFKGLATIRALNG 918
            |       .|..::|:.:||         :..||:....:|.: .:.|.|  |...:.|:|:...
Mouse   324 LSLVTFMGFPIIMMVSNIYG---------KYYKRLSKEVQSALARASTTAEETISAMKTVRSFAN 379

  Fly   919 TKYMERDF------HYYQNENTSALYLHVSINRAFAFWTDLICVLYILAVTFSFLLFDKHRGYYS 977
            .:.....|      .|..|...:|.|:      ::.:.:.|.    :|.|..|.|.:..|. ..|
Mouse   380 EEEEAEVFLRKLQQVYKLNRKEAAAYM------SYVWGSGLT----LLVVQVSILYYGGHL-VIS 433

  Fly   978 GDVG-----------LAITQSMKLVLMCQAGMRQTVELENMMTSVERVMEYVNIPSEPAYETEES 1031
            |.:.           ..:...|:.|....:|:.|.|      .:.|:|.|:::  .:|....:.|
Mouse   434 GQMSSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGV------GAAEKVFEFID--RQPTMVHDGS 490

  Fly  1032 VNLPKHWPSGGQLDFRDLRLRYSNHGPY--ILKGLTFTIRGEEKIGIVGHTAAGKSSIVHALFRL 1094
            : .|.|..  |::||.::...|... |:  :|:.::|::...:...:||.:.:||||.|:.|...
Mouse   491 L-APDHLE--GRVDFENVTFTYRTR-PHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENF 551

  Fly  1095 AHI-NGHISIDGFETSQLGLHD---LRRRISIIPQDPVLFSGSLRFNLD------PFEEKTDEEL 1149
            ..: .|.:.:||   ..:|.:|   |.|.||::.|:||||:.|:..|:.      |||...:
Mouse   552 YPLQGGRVLLDG---KPIGAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVE--- 610

  Fly  1150 WLALEAVKLKEFVSNLKDGINCRLHDCGANFSMGQRQLVCLARALLRQNKILIMDEATANVDPET 1214
              |.:......|:..|:||.:....:.||..|.||:|.|.:||||:|...:||:||||:.:|.|:
Mouse   611 --AAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAES 673

  Fly  1215 DNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGRVVELGHPHELLHNRHGYLHRFVEKT 1279
            :.|||:|||......|||.|||||.||.....::|:|.||||:.| .|:.|..:.|...:.|::.
Mouse   674 EYLIQQAIHGNLQRHTVLIIAHRLSTVERAHLIVVLDKGRVVQQG-THQQLLAQGGLYAKLVQRQ 737

  Fly  1280 GVG-------TAQH 1286
            .:|       ||.|
Mouse   738 MLGLEHPLDYTASH 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	159/637 (25%)
		ABC_membrane	92..358	CDD:294371
		ABCC_MRP_domain1	423..626	CDD:213217
		ABC_membrane	762..988	CDD:294371	47/273 (17%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	82/230 (36%)
Abcb9	NP_063928.2	3a01208	44..734	CDD:273363	160/645 (25%)
		ABC_membrane	189..451	CDD:279056	55/311 (18%)
		ABCC_TAP	489..714	CDD:213215	81/236 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000