DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11898 and Abcb10

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_062425.1	Gene:	Abcb10 / 56199	MGIID:	1860508	Length:	715	Species:	Mus musculus

Alignment Length:	622	Identity:	159/622 - (25%)
Similarity:	271/622 - (43%)	Gaps:	92/622 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   704 EYFKVLG--HPLVVVLILLMFVVARSSEATMD--IFLSKWATWEETEPNQHEPIPEYHRTRLRMM 764
            |.:|:||  .|....|...:..:|.||..||.  .||.:......|.|::     .|..:..|:.
Mouse   121 EVWKLLGLVRPERGRLSAAVGFLAVSSVITMSAPFFLGRIIDVIYTNPSE-----GYGDSLTRLC 180

  Fly   765 ILYTFLILC-----TLIFYVLRTFGFFMMTLRISLRIHDQLFQGVIRAFMHFFTLATSGRILNRF 824
            .:.|.:.||     .:..|::::.|..::.     |:...||..::|..:.||....:|.::||.
Mouse   181 AVLTCVFLCGAAANGIRVYLMQSSGQSIVN-----RLRTSLFSSILRQEVAFFDKTRTGELINRL 240

  Fly   825 SSDVLAIDVNLPQAMMDSIEFAVNALAVLAVV-----STANIWL-LIPATVVVALLYGCRCLYIG 883
            |||...:..::.:.:.|.:.....|...:.::     |.|...| ::|...|:|::||
Mouse   241 SSDTALLGRSVTENLSDGLRAGAQASVGVGMMFFVSPSLATFVLSVVPPISVLAVIYG------- 298

  Fly   884 ASRSLKRIETISRSPIYSHTNATFKGLATIRALNG--------TKYMERDFHYYQNENTSALYLH 940
              |.|:::...::..:...|....:.:..||.:..        .||..|.....|.....||
Mouse   299 --RYLRKLSKATQDSLAEATQLAEERIGNIRTIRAFGKEMTEVEKYTGRVDQLLQLAQKEAL--- 358

  Fly   941 VSINRAFAFWTDLICVLYILAVTF-----------------SFLLFDKHRGYYSGDVGLAITQSM 988
              ....|.....|...|.:|:|.:                 |||:       |:..|||:|
Mouse   359 --ARAGFFGAAGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLM-------YAFWVGLSI---- 410

  Fly   989 KLVLMCQAGMRQTV-ELENMMTSVERVMEYVNIPSEPAYETEESVNLPKHWPSGGQLDFRDLRLR 1052
                   .|:.... ||...:.:..|:.|.  :..:|.....|.:.|.:. ...|.|:||::...
Mouse   411 -------GGLSSFYSELMKGLGAGGRLWEL--LERQPRLPFNEGMVLDEK-TFQGALEFRNVHFT 465

  Fly  1053 Y-SNHGPYILKGLTFTIRGEEKIGIVGHTAAGKSSIVHALFRLAHIN-GHISIDGFETSQLGLHD 1115
            | :.....:.:..:.:|.......:||.:.:|||::|..|.||...| |.:|:||.:..||....
Mouse   466 YPARPEVSVFQDFSLSIPSGSVTALVGPSGSGKSTVVSLLLRLYDPNSGTVSLDGHDIRQLNPVW 530

  Fly  1116 LRRRISIIPQDPVLFSGSLRFNL----DPFEEKTDEELWLALEAVKLKEFVSNLKDGINCRLHDC 1176
            ||.:|..:.|:|||||.|:..|:    |.....|.:::..|.|.....||:.:...|.:..:.:.
Mouse   531 LRSKIGTVSQEPVLFSCSVAENIAYGADNLSSVTAQQVERAAEVANAAEFIRSFPQGFDTVVGEK 595

  Fly  1177 GANFSMGQRQLVCLARALLRQNKILIMDEATANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHTV 1241
            |...|.||:|.:.:|||||:..|||::||||:.:|.|.::|:|||:.......|||.|||||.|:
Mouse   596 GILLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEHLVQEALDRLMEGRTVLIIAHRLSTI 660

  Fly  1242 MDNDRVMVVDMGRVVELGHPHELLHNRHGYLHRFVEK 1278
            .:.:.|.|:|.|::.|.|...|||...:|...:.:.|
Mouse   661 KNANFVAVLDHGKICEHGTHEELLLKPNGLYRKLMNK 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	157/610 (26%)
		ABC_membrane	92..358	CDD:294371
		ABCC_MRP_domain1	423..626	CDD:213217
		ABC_membrane	762..988	CDD:294371	52/261 (20%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	78/224 (35%)
Abcb10	NP_062425.1	3a01208	8..694	CDD:273363	158/617 (26%)
		ABC_membrane	142..403	CDD:279056	57/291 (20%)
		ABC_MTABC3_MDL1_MDL2	458..698	CDD:213216	81/240 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000