DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and abcc9

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	XP_005164758.1	Gene:	abcc9 / 561160	ZFINID:	ZDB-GENE-050517-23	Length:	1583	Species:	Danio rerio

Alignment Length:	1388	Identity:	386/1388 - (27%)
Similarity:	670/1388 - (48%)	Gaps:	197/1388 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 NFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLGHWEQELKRSK-----PNVL 76
            |..||..:.|...:::...:|.::...:.:...::.:......|...:|::.:.::     |::.
Zfish   223 NLLSKATYWWMNPLIIGAHKRPIELKKIGKLPIAMRALTNYLRLKDSYEEQRQNTEDPEKSPSIW 287

  Fly    77 RMIFKAYGWSFVPASIVYSIMAIAVHTTQPLMLGGLVSFFSES--------TGKITKHSAYLYAM 133
            :.:::|:|.|.:.:| .:..||..:....||.:.|:|.....|        ||.:| ...|..:.
Zfish   288 KSMYRAFGGSILLSS-TFRYMADLLGFAGPLCISGIVEHLHNSTEIDRTNKTGNMT-FGVYFMSS 350

  Fly   134 GVVL--CSLISGLFF------HPFMKYLFRV----GSRVRLACAGLVYRKFLRVSVAADNSG--V 184
            ..:|  .|:::.|.|      ..|::..:.|    |..:|.|...::|.|.||:|.:..:.|  .
Zfish   351 TELLQNTSVLAVLLFLALVLQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNMSMGEMT 415

  Fly   185 SGYAISLMATDLPTFNESFYCFHELWRGPLEGVVFVYIIYQLIGWPAVVGLGTIVAFIPLQAWAA 249
            .|...:|:|.:........:....||..|::.::.|.::|.|:|..|::|.|.|:...|:|...|
Zfish   416 LGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYYLLGNSALIGAGVILLLAPVQYLIA 480

  Fly   250 RAIARYKRSSADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIRGSTYIYAGL 314
            ..:|..::|:.|...:|:|...||:..::|:|:||||..|...:.:.|.:|:.|::  |:
Zfish   481 TKLADIQKSTLDYSTDRLKKTTEILKGIKLLKLYAWENIFCDRVEETRGKELTSLK--TF----- 538

  Fly   315 QCTGMISKLSLFLS--------LVTYV----FTGDIVTSQKVFIVASYYDHLNDSLLHSWPLAIN 367
               .:.:.:|:|::        |.|:|    ...|.::..|.|...:.: |:..:.|......:.
Zfish   539 ---ALHTSMSIFMNAAIPIAAVLATFVTHAYIEEDRLSPAKAFASLALF-HILVTPLFLLSTVVR 599

  Fly   368 MWVETFVVANRVKDFLFQHENPADGGVHNFKEAEDNPEHGNF-----FGRTHKPKAEVKSITVHK 427
            ..|:..|...::.:||...|           ..:|:..:|:.     .|:.:|.:.:.|:|. .|
Zfish   600 FAVKALVSVQKLSEFLQSDE-----------IGDDSWRNGDMCMSLEVGKKYKYQGDTKAIN-RK 652

  Fly   428 LSASWDQKKQEKRHR----HIEDVSFQAQD---------------------QQFVGIVGTVGAGK 467
            .....|..:|..|.:    ..|||:.|..|                     .|...|||.||.||
Zfish   653 GRYRMDNYEQPVRRQLRPSETEDVAVQVNDGFFTWGSNLSTLSDINIRIPTGQLTMIVGQVGCGK 717

  Fly   468 STLLQVILGELDIISGSV--------------EVNG---------------VLSYAPQEPWLLRG 503
            |:||..:|||:..|||.|              .::|               .::||.|:.|||..
Zfish   718 SSLLLAMLGEMQTISGKVYWSKLPDCEILFDGNISGHDMELSHEERSKNRYSVAYATQKSWLLNA 782

  Fly   504 SLRDNILFTEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLARAVYRK 568
            ::.:||.|..|:::|||..|:..|.|..|::.||.||.|.:||.|.:|||||:.|:.:|||:|:.
Zfish   783 TVEENITFGSPFNKQRYKAVIDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQN 847

  Fly   569 ADIYLLDDPLSAVDSHVSKMLLDRCLNEFL--SKKIRILVTHRVQLLRHVDHLVLLEGGRI---- 627
            .:|..||||.||:|.|:|..|:...:.:||  .|:..:||||::|.|.|.|.::.::.|.:
Zfish   848 TNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTVVLVTHKLQYLIHADWIIAMKDGSVLREG 912

  Fly   628 ---SVQGH----YDALKKLIRFRMSVANDVEVAKLRAMRTDSVYEEPEPRKSLSQEE---HMDRH 682
               .:|.|    |:..|.|:.     ..|.|:.|...:.:.:..|....|::....|   |:|..
Zfish   913 TLKDIQTHDVELYEHWKTLMN-----RQDQELEKDTDLESQTTLERKTLRRAFYSREAKNHVDDE 972

  Fly   683 EIEQQFKEQ--QQIGSVKLQTYKEYFKVL------GHPLVVVLILLMFVVARSSEATMDIFLSKW 739
            :.|::.:|:  ..:.:...:..|..:|:.      |..|:|.|::...:...|....:|.:|:.|
Zfish   973 DEEEEVEEEDDDNMSTTTSRRSKIPWKMCCCYLSSGGFLMVFLMVSSKLAKHSVMVAIDYWLAAW 1037

  Fly   740 ATWEETEPNQHE-----------------PIPEYHRTRLRMMILYTFLILC--TLIFYVLRTFGF 785
                 |..|.|.                 .|.| ||:.:.:     |:|||  .:...::.:...
Zfish  1038 -----TSSNPHNQSFVNSSFNHTLNDDATQIAE-HRSYVPV-----FIILCAAAIALCLITSLTV 1091

  Fly   786 FMMTLRISLRIHDQLFQGVIRAFMHFFTLATSGRILNRFSSDVLAIDVNLP---QAMMDSIEFAV 847
            ..:.:..:..:|..|...:|.|.:.||.:...|:||||||:|...||.::|   :::..|....:
Zfish  1092 EFLGVAAATNLHHNLLNKIIHAPIRFFDVTPLGQILNRFSADTNIIDQHIPPTLESLTRSTLLCL 1156

  Fly   848 NALAVLAVVSTANIWLLIPATVVVALLYGCRCLYIGASRSLKRIETISRSPIYSHTNATFKGLAT 912
            :|:.|:|.|:.|.:..|:|..|.   .|..:..:..||:.|:.::..::.|:..|.:.|.:||.|
Zfish  1157 SAIGVIAFVTPAFLIALVPLAVA---FYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTT 1218

  Fly   913 IRAL-NGTKYMERDFHYYQNENTSALYLHVSINRAFAFWTDLICVLYILAVTFSFLLFDKHRGYY 976
            |||. :..::.:|........||:.|:|..: ||.....||.:..:.:|....:.:.....
Zfish  1219 IRAFRHEARFKQRMLELTDTNNTAYLFLSAA-NRWLEVRTDYLGAVIVLTAAVAAIWSTSP---- 1278

  Fly   977 SGDVGLAITQSMKLVLMCQAGMRQTVELENMMTSVERVMEYVNIPSEPAYETEESVN-LPKHWPS 1040
            ||.|||.:|.::.|.......:|...:||..|.:|::|..:::..|| .||....|: :|:.||.
Zfish  1279 SGLVGLGLTYALTLTNYLNWVVRNLADLEVQMAAVKKVNSFLSTESE-NYEGSMDVSQVPEDWPQ 1342

  Fly  1041 GGQLDFRDLRLRYSNHGPYILKGLTFTIRGEEKIGIVGHTAAGKSSIVHALFRLAHI-NGHISID 1104
            .|::...||.:||.:....:||.:...|...:|:||.|.|.:||||:..|.|.:..: .|.|.||
Zfish  1343 HGEITIHDLCVRYDSMLKPVLKHVNAHINPGQKVGICGRTGSGKSSLSLAFFNMVDVFEGKIVID 1407

  Fly  1105 GFETSQLGLHDLRRRISIIPQDPVLFSGSLRFNLDPFEEKTDEELWLALEAVKLKEFVSNLKDGI 1169
            |.:..:|.|..||.|:|||.|||||||||:|.||||....||:.||.|||..:||..|..|..|:
Zfish  1408 GIDICKLPLQTLRSRLSIILQDPVLFSGSIRLNLDPERTCTDDRLWEALEIAQLKNMVKALPGGL 1472

  Fly  1170 NCRLHDCGANFSMGQRQLVCLARALLRQNKILIMDEATANVDPETDNLIQEAIHTKFAHCTVLTI 1234
            :..:.:.|.|||:|||||.|||||.:|::.|||||||||::|..|:|::|:.:.|.||..||:||
Zfish  1473 DAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTI 1537

  Fly  1235 AHRLHTVMDNDRVMVVDMGRVVE 1257
            ||.:.::::.::|:|...|.:||
Zfish  1538 AHLVSSILEAEQVLVFSSGILVE 1560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	386/1388 (28%)
		ABC_membrane	92..358	CDD:294371	70/299 (23%)
		ABCC_MRP_domain1	423..626	CDD:213217	86/258 (33%)
		ABC_membrane	762..988	CDD:294371	59/231 (26%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	100/217 (46%)
abcc9	XP_005164758.1	CFTR_protein	223..1575	CDD:273530	386/1388 (28%)
		ABC_membrane	304..591	CDD:294371	70/298 (23%)
		ABCC_SUR1_N	678..907	CDD:213257	78/228 (34%)
		ABC_membrane	1045..1300	CDD:294371	64/268 (24%)
		ABCC_SUR2	1269..1583	CDD:213255	121/297 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586001
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740