DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and abcc13

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	XP_017209479.1	Gene:	abcc13 / 559093	ZFINID:	ZDB-GENE-050517-26	Length:	1020	Species:	Danio rerio

Alignment Length:	1333	Identity:	276/1333 - (20%)
Similarity:	479/1333 - (35%)	Gaps:	415/1333 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 QPNPVTKANFFSKWFFIWTREILVKGLQRNLDPSDLYE--TEPSLESTQVSSFLLGHWEQE---- 67
            |.:||           ::...::|.|.:..|...||.:  .|.|:.:  :.|.....||::
Zfish    19 QTSPV-----------LYNMRMVVMGHRGPLQLFDLLKLYNEDSVHT--LCSVFDHEWEKQQNNY 70

  Fly    68 ---------------LKRSKPN----VLRMIFKAYGWSFVP------ASIVYSIMAIAVHTTQPL 107
                           |..||.|    :|..::|.:..|.:.      :|.::||:.       |:
Zfish    71 KERSDLEDDSGRKSLLVTSKTNAGYSLLYTLWKTFHPSLIKIVLLRLSSDLFSILV-------PI 128

  Fly   108 MLGGLVSFFSES------TGKITKHSAYLYAMGVVLCSLISGLFF-HPFMKYLFRVGSRVRLACA 165
            .:..:: .|||.      ||       |.||: ||..:|..|.|. |.|.|....:.:......:
Zfish   129 TIRWVI-LFSERQAMFGWTG-------YTYAL-VVFGALCCGAFSQHHFEKRSRIITANAHAILS 184

  Fly   166 GLVYRKFLRVSVA------ADNS------GVSGYAISLMATDLPTFNESFYCFHELWRGPLEGVV 218
            |.||||...:|::      :|.|      |.:.....|:.|        ..|   :|..||...:
Zfish   185 GTVYRKIKTLSLSHSSRWHSDTSHREDMLGEAERVAELVVT--------LAC---IWSSPLRVTL 238

  Fly   219 FVYIIYQLIGWPAVVGLGTIVAFIPLQAWAARAIARYKRSSADVGDERVKLMNEIIAAMQLIKMY 283
            ::.:::..:|...:||:..::..||:::...|...:.:|:...:.::..:|:.|::...|.:|:.
Zfish   239 YLGLLWAKLGPSVLVGVTLLLVLIPVKSAVERKAKQLRRTHRVIREKSEQLIKEMLHKYQALKLL 303

  Fly   284 AWEKSFAKLIGKVRKEEMDSIRGSTYIYAGLQCTGMISK-----LSLFLSLVTYVFT--GDIVTS 341
            .||..|.:.:.:.|..|::.:|    |...|....|:..     |.:|.||..:|..  |:::||
Zfish   304 TWESWFFQRVTESRTRELEMLR----IQGFLTAFSMLDSICMPFLVIFSSLGAFVLVDDGNVLTS 364

  Fly   342 QKVFIVASYYDHLNDSLLHSWPLAINMWVETFVVANRVKDFLFQHENPADGGVHNFKEAEDNPEH 406
            .::|....::..|...||
Zfish   365 SQIFTSVCFFRLLRPPLL----------------------------------------------- 382

  Fly   407 GNFFGRTHKPKAEVKSITVHKLSASWDQKKQEKRHRHIEDVSFQAQDQQFVGIVGTVGAGKSTLL 471
                                                            :|:|:.
Zfish   383 ------------------------------------------------EFLGLF----------- 388

  Fly   472 QVILGELDIISGSVEVNGVLSYAPQEPWLLRGSLRDNILFTEPYDEQRYLEVLRVCHLDRDVEQL 536
                             .||..|.|.                            .|:|::.....
Zfish   389 -----------------SVLKQAQQS----------------------------FCYLEKIFLTE 408

  Fly   537 PLGDSTRVGEGGASLSGGQKARVSLARAVYRKADIYLLDDPLSAVDSHVSKMLLDRCLNEFLSKK 601
            .||.|..:.:|...                           .|:.||  ::...|.|
Zfish   409 DLGTSQFLTKGATE---------------------------ESSADS--TQQPCDEC-------- 436

  Fly   602 IRILVTHRVQLLRHVDHLVLLEGGRISVQGHYDALKKLIRFRMSVANDVEVAKLRAMRTDSVYEE 666

Zfish   437 ----------------------------------------------------------------- 436

  Fly   667 PEPRKSLSQEEHMDRHEIEQQFKEQQQIGSVKLQTYKEYFKVLGHPLVVVLILLMFVVARSSEAT 731
              ..|....:|..|.:....:|:|...:          |....|...|.|..|:...|...|.|
Zfish   437 --QEKQNDSDEKRDHYHFRNEFREACWL----------YLGAFGWHWVSVCSLVYLSVCAVSLA- 488

  Fly   732 MDIFLSKWATWEETEPNQHEPIPEYHRTRLR----MMILYTFLILCTLIFYVLRTFGFFMMTLRI 792
            .|..|..| |.|..|....:...|...:||.    :.:|..||:.|..  |.| |.|    :|:.
Zfish   489 QDGVLCMW-TGEAKEVQGLDGWKELRNSRLSAYALLGLLQAFLVCCAA--YCL-TCG----SLKA 545

  Fly   793 SLRIHDQLFQGVIRAFMHFFTLATSGRILNRFSSDVLAIDVNLPQAMMDSIEFAVNALAVLAVVS 857
            |..:|.:|...|:...:|...:.|. :::...:.|:..||..||:.:...::..::.|:.:.::|
Zfish   546 SRTLHTELLSDVLHLPVHSQKMNTR-KLMQALTQDMQVIDEELPKHLHSILKSLLDVLSTITLIS 609

  Fly   858 -TANIWLLIPATVVVALLYGCRCLYIGASRSLKRIETISRSPIYSHTNATFKGLATIRALNGTKY 921
             ...::.|....:::.||:    :....|.:..:|..:..:|..|.|:..........:|:|.::
Zfish   610 FIIPVFSLAVCPMIILLLH----IQSRISSTHMQIRNMEANPAVSLTSLARVTQCAEASLSGPEH 670

  Fly   922 MERDF-HYYQ--NENTSALYLHVSINRAFAFWTDLICVLYILAVTFSFLLFDKHRGYYSGDVGLA 983
            ..... |..|  .:|....|..::.......|.|.:..:.:|.|:...|......|.
Zfish   671 RAVCLKHCLQAFTQNLLLKYNTINTESWVVLWFDGVAGIVLLLVSLILLQTQPESGL-------- 727

  Fly   984 ITQSMKLVLMCQAGMRQTVE--------LENMMTSVERVMEYVNIPSEPAYETEESVNL--PKHW 1038
                :.|.|:|...:::.:.        :...|.|::.:.:    .::...|.|.:||.  |..|
Zfish   728 ----VALTLICSFNIKEALHYCPQAASVITTDMLSLQNLFD----SAKAEKEAEWTVNYRPPYDW 784

  Fly  1039 PSGGQLDFRDLRLRYSNHGPYILKGLTFTIRGEEKIGIVGHTAAGKSSIVHALFRLAHI-NGHIS 1102
            |..|::.||:.....|:.|...|:|:..||...||||:|.........::::|||.... :|.:.
Zfish   785 PQHGEVKFRNYESEASSDGTPALRGVHLTILKGEKIGVVSRQKTDTDVLINSLFRSVEARSGALL 849

  Fly  1103 IDGFETSQLGLHDLRRRISIIPQDPVLFSGSLRFNLDPFEEKTDEELWLALEAVKLKEFVSNLKD 1167
            ||....|::||||||.|:.||.|.||||||.||.|||||.|.:|.::|||||...|||.|..:..
Zfish   850 IDNINISRMGLHDLRGRLQIISQVPVLFSGPLRANLDPFAEHSDAQVWLALELCHLKESVQQMPA 914

  Fly  1168 GINCRLHDCGANFSMGQRQLVCLARALLRQNKILIMDEATANVDPETDNLIQEAIHTKFAHCTVL 1232
            .:...:......||.|||:|:|||||||.:.:||:::|...:|||||::|:|:.||.:|..||||
Zfish   915 QLLHPVQRTALAFSFGQRRLLCLARALLARVRILLVEEPLHHVDPETEDLLQQVIHAEFKDCTVL 979

  Fly  1233 TIAHRLHTVMDNDRVMVVDMGRVVELGHPHELL 1265
            .::....:|:..|||:|:|.|:.|:...|..||
Zfish   980 FLSQNPLSVLHTDRVLVLDKGQAVKFDAPSTLL 1012

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	276/1333 (21%)
		ABC_membrane	92..358	CDD:294371	64/291 (22%)
		ABCC_MRP_domain1	423..626	CDD:213217	17/202 (8%)
		ABC_membrane	762..988	CDD:294371	42/233 (18%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	93/219 (42%)
abcc13	XP_017209479.1	SunT	29..>409	CDD:331423	92/563 (16%)
abcc13	XP_017209479.1	SunT	<461..1018	CDD:331423	167/592 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586118
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840