DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG11898 and cftr

DIOPT Version :9

Sequence 1:NP_651679.2 Gene:CG11898 / 43451 FlyBaseID:FBgn0039645 Length:1320 Species:Drosophila melanogaster
Sequence 2:NP_001038348.1 Gene:cftr / 559080 ZFINID:ZDB-GENE-050517-20 Length:1485 Species:Danio rerio


Alignment Length:1505 Identity:403/1505 - (26%)
Similarity:695/1505 - (46%) Gaps:282/1505 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 QPNPVTKANFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQV-SSFLLGHWEQELK--R 70
            |.:||..||..|::||.||..|:.||.:..|.|||:|:. ||.::..: :..|...|::|:.  :
Zfish     2 QRSPVEDANCLSRYFFWWTNPIMRKGFKEKLRPSDVYQA-PSQDAADILAERLEKEWDREVASGK 65

  Fly    71 SKPNVLRMIFKAYGWSFVPASIVYSIMAIAVHTTQPLMLGGLVSFFSESTGKITKHSAYLYAMGV 135
            .||::||.:.:.|...|:....:..| ..|..|.||.:||.:::.| :...:..:.:.|..|.|:
Zfish    66 KKPSLLRAMARCYIKPFLLFGFLLYI-GEATKTVQPQLLGRIIASF-DPAHEPERANGYFLAFGL 128

  Fly   136 VLCSLISGLFFHPFMKYLFRVGSRVRLACAGLVYRKFLRVSVAADNSGVSGYAISLMATDLPTFN 200
            .|......|...|.|..|..:|.::|:|...::|:|.|::|....:...:|..:|||:.:|..|:
Zfish   129 GLLFTARFLLLQPAMFGLHHLGMQIRIALFSIIYKKTLKLSSRVLDKISTGQLVSLMSANLGKFD 193

  Fly   201 ESFYCFHELWRGPLEGVVFVYIIYQLIGWPAVVGLGTIVAFIPLQAWAARAIARYKRSSADVGDE 265
            :|....|.:|..||:.::...:|::||...:...|..|.....|||:.:..:..||.....:.::
Zfish   194 QSLGMAHFIWISPLQCILCTGLIWELIDVNSFCALAAISLLGVLQAFLSHKMGPYKAQKVLLTNK 258

  Fly   266 RVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIR--GS-TYIYAGLQCTGMISKLSLFL 327
            |:.|.:||:..:..:|.|.||:....||..:|::|:...|  || .|.|:.          :.|.
Zfish   259 RLALTSEIMENLHSVKAYGWEEIMETLIKNIRQDEVKLTRKIGSLRYFYSS----------AYFF 313

  Fly   328 SLVTYVFTGDI-------VTSQKVFIVASYYDHLNDSLLHSWPLAINMWVETFVVANRVKDFLFQ 385
            |.:..:....:       :..:::|...||...|..::....|.:|.||.:|..:..::::||.:
Zfish   314 SAIFVIVAAVVPHALSRGINLRRIFTTLSYCMVLRMTVTRQLPGSIQMWYDTMRLIWKIEEFLSK 378

  Fly   386 HENPADGGVHNFKEAEDNPEHGNFFGRTHKPKAEVKSITVHKLSASWDQ---------KKQEKRH 441
            .|         :|..|.:              ..:..:.:..::||||:         |::.|.:
Zfish   379 EE---------YKLMEYD--------------LSITELELQDVTASWDEGPGELLERIKQENKAN 420

  Fly   442 RH-----------------IEDVSFQAQDQQFVGIVGTVGAGKSTLLQVILGELDIISGSVEVNG 489
            .|                 ::|:|.:.:..:.:.:.|::|:|||:||..|||||...||.:..:|
Zfish   421 GHHNGDAGLFFTNLYVAPVLKDISLKLKKGEMLAVTGSMGSGKSSLLMTILGELVPSSGKIRHSG 485

  Fly   490 VLSYAPQEPWLLRGSLRDNILFTEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGG 554
            .:||:.|..|::.|::||||||...|||.||..|::.|.|:.|:..||..|.|.:.|||.:||||
Zfish   486 RISYSSQTAWIMPGTIRDNILFGLTYDEYRYKSVVKACQLEEDLAALPEKDKTPMAEGGLNLSGG 550

  Fly   555 QKARVSLARAVYRKADIYLLDDPLSAVDSHVSKMLLDRCLNEFLSKKIRILVTHRVQLLRHVDHL 619
            |||||:|||||||.||:||||.|.:.:|....|.:.|:||.:.::.|.|||||::::.|:..|.:
Zfish   551 QKARVALARAVYRDADLYLLDAPFTHLDIATEKEIFDKCLCKLMASKTRILVTNKIEHLKRADKI 615

  Fly   620 VLLEGG---------------------------------------------RISV---------- 629
            :||..|                                             |:||          
Zfish   616 LLLHNGESFFYGTFPELQSERPDFSSLLLGLEAYDNISAERRCSILTETLHRVSVDESAGMQPER 680

  Fly   630 ----------------------------------------------------------------- 629
                                                                             
Zfish   681 SAFRQVPPTKPMYIDERKASVIVNPLGVARKASFIQVPEEEVRRTLPDRKFSLVPENELVDESFM 745

  Fly   630 -----------------------------QGHYDALKKLIRFRMSVANDVEVAKLRAMRT----D 661
                                         ||..:.|:...|.|:||....|:|....:.|    |
Zfish   746 GSDVYHNHGVHMAGQRRQSVLAFMTNAQGQGRREHLQSSFRRRLSVVPQSELASELDIYTRRLSD 810

  Fly   662 SVYEEPEPRKSLSQEEHMDR------HEIEQQFKEQQQIGSVKLQTYKEYFKVLGHPLVVVLILL 720
            |.|:    ...:.:||:::.      .|||:.|:      :.|..||..|.. ....|:.|||.:
Zfish   811 STYD----MTGILEEENIEACLTDEIDEIEETFE------TTKWNTYVRYVS-NNKSLLYVLIFI 864

  Fly   721 MFVVA-RSSEATMDIFLSKWATWEETEPNQHEPIPEYHRTRLRMMILYTFLILCTLIFYVLRTF- 783
            :|:.| ..:.:...|||.....|.| |..:.||....|.........|...:..|..:|:|..: 
Zfish   865 LFIAAIEIAGSVAGIFLITDELWRE-EHQRSEPNMTKHSNASSSGQTYAITVTPTSSYYILYIYV 928

  Fly   784 ---------GFFM------MTLRISLRIHDQLFQGVIRAFMHFFTLATSGRILNRFSSDVLAIDV 833
                     |||.      .|:.||.::|.::...|:.|.|.......:|||:|||:.|:..||.
Zfish   929 ATSESLLAMGFFRGLPFVHTTITISKKLHQKMLHAVLSAPMSVLNTMKTGRIMNRFTKDMATIDD 993

  Fly   834 NLPQAMMDSIEFAVNALAVLAVVSTANIWLLIPATVVVALLYGCRCLYIGASRSLKRIETISRSP 898
            .||..|.|.::..|..:..:.|||....::.:.||.:..:....|..::...:.||::||.:|||
Zfish   994 MLPLLMFDFVQLTVVVVGCILVVSIVRPYIFLAATPLAIIFIVMRKYFLRTGQQLKQLETEARSP 1058

  Fly   899 IYSHTNATFKGLATIRALNGTKYMERDFHYYQNENTSALYLHVSINRAFAFWTDLICVLYILAVT 963
            |:||...:.|||.||||.....|.|..||...|.:|:..:|::|..|.|.|..|::.|.:.....
Zfish  1059 IFSHLIMSLKGLWTIRAFERQAYFEALFHKTLNTHTATWFLYLSTLRWFLFRADILFVFFFTLAA 1123

  Fly   964 FSFLLFDKHRGYYSGDVGLAITQSMKLVLMCQAGMRQTVELENMMTSVERVMEYVNIPSE-PAYE 1027
            :..:..::.:   .|::|:.|..:|.::...|..:..::.::.||.||:||.:::::||| |..:
Zfish  1124 WIAVGTNQDK---PGEIGIIICLAMLILGTFQWCVATSIAVDGMMRSVDRVFKFIDLPSETPKPD 1185

  Fly  1028 TEESVNL---------PKHWPSGGQLDFRDLRLRYSNHGPYILKGLTFTIRGEEKIGIVGHTAAG 1083
            ..:..:|         ...||..||::.|:|.::|:..|..:||.|:|:..|.:::||:|.|.:|
Zfish  1186 KGKDSDLIIENVDAQADSSWPHRGQIEVRNLTVKYTEAGHAVLKNLSFSAEGRQRVGILGRTGSG 1250

  Fly  1084 KSSIVHALFRLAHINGHISIDGFETSQLGLHDLRRRISIIPQDPVLFSGSLRFNLDPFEEKTDEE 1148
            |||:.:||.:|.:.:|.|||||...:::.|...|:...::||...:|:|.||.||||:...:|||
Zfish  1251 KSSLFNALLKLVYTDGEISIDGVNWNKMPLQKWRKAFGVVPQKVFIFTGPLRMNLDPYGCHSDEE 1315

  Fly  1149 LWLALEAVKLKEFVSNLKDGINCRLHDCGANFSMGQRQLVCLARALLRQNKILIMDEATANVDPE 1213
            ||...|.|.||..:....|.::.:|...|...|.|.:||:||||::|...:||::||.:|::||.
Zfish  1316 LWRVAEEVGLKTVIEQFPDKLDFQLEYGGYVLSNGHKQLICLARSILSGARILLLDEPSAHLDPV 1380

  Fly  1214 TDNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGRVVELGHPHELLHNRHGYLHRFVEK 1278
            |..::::.:...|:.||:|...|::..:::....:::|.|:|.......:|| |...:|     |
Zfish  1381 TIKVLKKTLRQSFSTCTILLSEHKVEPLLECQSFLMMDKGQVKTYDSIQKLL-NETSHL-----K 1439

  Fly  1279 TGVGTAQHLR 1288
            ..:..|:.|:
Zfish  1440 QAISPAERLK 1449

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG11898NP_651679.2 CFTR_protein 9..1268 CDD:273530 398/1483 (27%)
ABC_membrane 92..358 CDD:294371 67/275 (24%)
ABCC_MRP_domain1 423..626 CDD:213217 90/273 (33%)
ABC_membrane 762..988 CDD:294371 67/241 (28%)
ABCC_MRP_domain2 1042..1261 CDD:213211 77/218 (35%)
cftrNP_001038348.1 AAA 1..1485 CDD:333001 403/1505 (27%)
Disordered R region. /evidence=ECO:0000250|UniProtKB:P13569 653..826 18/176 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1452..1485
PDZ-binding. /evidence=ECO:0000250|UniProtKB:P13569 1483..1485
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170586104
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24223
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
54.850

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