DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and abcc10

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	XP_005155817.1	Gene:	abcc10 / 556709	ZFINID:	ZDB-GENE-050517-24	Length:	1548	Species:	Danio rerio

Alignment Length:	1354	Identity:	419/1354 - (30%)
Similarity:	664/1354 - (49%)	Gaps:	160/1354 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 ANFFSKWFFIWTREILVKGLQRNLD-PSDLYETEPSLESTQVSSFLLGHWEQEL----------- 68
            ::..|:..::|...:|.:|.:..|. |||::|....|.:..|:......||:.|
Zfish   231 SSLLSRLLYLWLNPLLNRGKRGELGRPSDVFELPSRLRTKSVTRRFYQCWEKCLHSRALERPERP 295

  Fly    69 -KRSKPN------------------------VLRMIFKAYGWSFV---PASIVYSIMAIAVHTTQ 105
             :|.:.|                        :|:::.||:|..:.   ...:|.|::|.|    .
Zfish   296 DRRPRGNLQDNSWSEAQPERICEGEAEHEVKLLQVLHKAFGLRYYLLGGLKLVASMLAFA----G 356

  Fly   106 PLMLGGLVSFFSESTGKITKHSAYLYAMGVVLCSLISGLFFHPFMKYLFRVGSRVRLACAGLVYR 170
            ||:|||||.|.......::|  ....|:|:...:.::.|..:.|:..:.:|....|.|....:|.
Zfish   357 PLLLGGLVGFMETEGAPLSK--GVWCAVGLFASTFLAALLKNIFVYEVSKVALEARAAVISTIYC 419

  Fly   171 KFLRV---SVAADNSGVSGYAISLMATDLPTFNESFYCFHELWRGPLEGVVFVYIIYQLIGWPAV 232
            |.|:|   |:|..|   .|..::.|:||.......|..|||:|..|.:.|:.:|::|..:|...:
Zfish   420 KALKVNAPSLARFN---MGEVVNFMSTDTDRVVNFFNSFHEVWSLPFQFVLALYLLYLQVGVAFL 481

  Fly   233 VGLGTIVAFIPLQAWAARAIARYKRSSADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVR 297
            .|:|..|..:||....|..|....:......|.|||||.||:..::::|.|.||:.|.:.|.:.|
Zfish   482 GGVGVAVLLVPLNKVLASRILENNKHMLQHKDGRVKLMTEILFGIRVLKYYNWEEHFTQKIEEAR 546

  Fly   298 KEEMDSIRGSTYIYAGLQCTGMISKLSLFLSL---VTYVFTGDIVTSQKVFIVASYYDHLNDSLL 359
            |:|:..::...|:.|  .|....:.|.:.:|:   :|||..|:.:|:.|||...:....| ...|
Zfish   547 KKELHHLKLLKYLDA--VCVYTWAALPVVISILTFITYVLLGNNLTAAKVFSTLALVGML-ILPL 608

  Fly   360 HSWPLAINMWVETFVVANRVKDFLFQHENPADGGVHNFKEAEDNPEHGNFFGRTHKPKAEVKSIT 424
            :::|..:|..:|..|..:|::.||...:.  |..|:..:...::|           |.|    :.
Zfish   609 NAFPWVLNGTLEAKVSLDRIQRFLAVQDQ--DLSVYYSQVCPEDP-----------PSA----VQ 656

  Fly   425 VHKLSASWDQKKQ---------------EKRHRHIEDVSFQAQDQQFVGIVGTVGAGKSTLLQVI 474
            :.:.|.||.|.::               ..|..::..::...:....|.:||.||.|||:||..|
Zfish   657 MVQASFSWKQSEEADSVSIPDDITEEGSPPRSFYLHALNLNVKMGSLVVVVGKVGCGKSSLLAAI 721

  Fly   475 LGELDIISGSVEVNG---VLSYAPQEPWLLRGSLRDNILFTEPYDEQRYLEVLRVCHLDRDVEQL 536
            .|||....|.|.|.|   ....|.||||:...:::|||||...||...|..|::.|.|..|:..|
Zfish   722 TGELTRCGGEVFVQGREQGFGLAVQEPWIQHATVQDNILFGRDYDNMFYQSVIQACALADDLNIL 786

  Fly   537 PLGDSTRVGEGGASLSGGQKARVSLARAVYRKADIYLLDDPLSAVDSHVSKMLLDRCLNEFLSKK 601
            |.||.|.|||.|.:||||||:|::||||||...:||||||||:|||:.|:..|:::|:...|..|
Zfish   787 PGGDQTEVGENGVTLSGGQKSRLALARAVYMDKEIYLLDDPLAAVDADVAHHLMEKCILGILKDK 851

  Fly   602 IRILVTHRVQLLRHVDHLVLLEGGRISVQGHYDALKKLIRFRMSVANDVEVAKLRAMRTDSVYEE 666
            .|||.|||::.:...|.:||::.|.|...|....:..|::......|     ...|...||...|
Zfish   852 TRILCTHRIEFVDKADVVVLMDNGMIVKTGAPSEVLSLVKGPKDSKN-----SSNAKEKDSAGSE 911

  Fly   667 PEPRKSLSQEEHMDRHEIEQQFKEQQQIGSVKLQTYKEYFKVLGHPLVVVLILLMFVVARSSEAT 731
                 .:...|...:.|:|...:||:|:|::....|:.|:|.:|..:.|.::|.:|:: ::|:..
Zfish   912 -----EMEASEPELKAELEMFGEEQKQMGTLSWAVYRSYWKAVGGCMAVAVLLALFLM-QASKNV 970

  Fly   732 MDIFLSKW-----------------------------------ATWEETEPNQHEPIPEYHRTRL 761
            .|.:||.|                                   |...|:..|....:..|
Zfish   971 SDWWLSHWISHMKDNMTELVSVSATPLLMLSFLSPGRLVFNAPARGSESSGNMSSELKFY----- 1030

  Fly   762 RMMILYTFLILCTLIFYVLRTFGFFMMTLRISLRIHDQLFQGVIRAFMHFFTLATSGRILNRFSS 826
              |.:|..|.....:|...|.|.|....:..:..:|.:|...|::|.|.||.....|||||||||
Zfish  1031 --MTVYGSLAAANTVFTAARAFLFAYGAICAATVVHKRLLSSVLKATMTFFDTTPLGRILNRFSS 1093

  Fly   827 DVLAIDVNLPQAMMDSIEFAVNALAVLAVVSTANIWLLIPATVVVALLYGCRCLYIGASRSLKRI 891
            |:.::|.:||..:...:......|.:|.|:|....|:|:|...:.||.|..:|.|..:||.|||:
Zfish  1094 DIYSVDDSLPFVLNILLANVFGLLGMLIVMSYGLPWVLLPLVPLGALYYQTQCFYRYSSRELKRL 1158

  Fly   892 ETISRSPIYSHTNATFKGLATIRALNGTKYMERDFHYYQNENTSALYLHVSINRAFAFWTD---- 952
            .:::.||:|||.:.|..||:|:|....|...|.:......:|...|:   :.|.|.. |.|
Zfish  1159 CSLTLSPVYSHFSETLSGLSTVRGSGHTTRFEEENERRLEQNQRCLF---NSNAAMQ-WLDIRLQ 1219

  Fly   953 LICVLYILAVTFSFLLFDKHRGYYSGDVGLAITQSMKLVLMCQAGMRQTVELENMMTSVERVMEY 1017
            :|.|..:..::...::..:.:....|.|||:::.::.:..:....:....:.|..:.|:||..||
Zfish  1220 MIAVTVVTGISVIAVIQHQLKSIDPGLVGLSLSYALSITNLLSGLIFSYAQTEMQLVSIERTEEY 1284

  Fly  1018 -VNIPSEPAYETEESVNLPKHWPSGGQLDFRDLRLRYSNHGPYILKGLTFTIRGEEKIGIVGHTA 1081
             .:||.||   .:.|:.:...||...:::|.|:.|.|....|..|.|::..:...|||||||.|.
Zfish  1285 STSIPQEP---QQASLEVLDRWPERARVEFVDVVLSYRPGLPNALDGVSVEVLPGEKIGIVGRTG 1346

  Fly  1082 AGKSSIVHALFRLAHIN-GHISIDGFETSQLGLHDLRRRISIIPQDPVLFSGSLRFNLDPFEEKT 1145
            :||||:..||||:..:| |.|.:||.:.|.:.|.|||.:::||||||.|||.|:|.||||.....
Zfish  1347 SGKSSLFLALFRMVELNQGQILLDGVDISSVRLSDLRSKLAIIPQDPFLFSSSVRENLDPHGRHP 1411

  Fly  1146 DEELWLALEAVKLKEFVSNLKDGINCRLHDCGANFSMGQRQLVCLARALLRQNKILIMDEATANV 1210
            |..|..|||...|...|.. ..|::..:.:.|.:.|:|||||:|||||||.:..||.:|||||:|
Zfish  1412 DYRLLEALEQCHLGNVVQR-NGGLDSEVGERGKSLSVGQRQLLCLARALLTEANILCIDEATASV 1475

  Fly  1211 DPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGRVVELGHPHEL 1264
            |.:||.|:|:.|..||...|||||||||:|:||:|:|:|:..|:|||...|..|
Zfish  1476 DQKTDMLLQKTIREKFKDKTVLTIAHRLNTIMDSDKVLVMHAGKVVEFDSPATL 1529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	419/1354 (31%)
		ABC_membrane	92..358	CDD:294371	79/271 (29%)
		ABCC_MRP_domain1	423..626	CDD:213217	87/220 (40%)
		ABC_membrane	762..988	CDD:294371	68/229 (30%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	105/219 (48%)
abcc10	XP_005155817.1	SunT	248..1531	CDD:331423	416/1337 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586031
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.650