DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and abcc8

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	XP_005170744.1	Gene:	abcc8 / 553281	ZFINID:	ZDB-GENE-050517-22	Length:	1594	Species:	Danio rerio

Alignment Length:	1436	Identity:	407/1436 - (28%)
Similarity:	651/1436 - (45%)	Gaps:	257/1436 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 NFFSKWFFIWTREILVKGLQRNLDPSDL----------------------YETEPSLEST--QVS 57
            |..||..:.|....:....:|   |.||                      :|.:...:.|  |.|
Zfish   236 NLLSKSTYWWMNTFITSAHRR---PIDLKVIGRLPIAMRALTNYIKLRQAFEAQKGPQDTPPQGS 297

  Fly    58 SFLLGHWEQELKRSKPNVLRMIFKAYGWSFVPASIVYSIMAIAVHTTQPLMLGGLVSFFSESTGK 122
            .::.....|..  .||.:|              ||.|..||..:....||.:.|:|...|:....
Zfish   298 KWIWAALRQAF--GKPLIL--------------SITYRFMADLLGFAGPLCISGIVHHLSKENHT 346

  Fly   123 I---TKH-------SAYLYAMGVVLCSLISGLFFHPFMKYLF---------RVGSRVRLACAGLV 168
            |   .||       |....|.|.||..|   |||...::..|         ..|..:|.|....:
Zfish   347 ILPPVKHLGMYFISSQEFLANGYVLAVL---LFFALLLQRTFLQASYYVAIETGINLRGAIQTKI 408

  Fly   169 YRKFLRVSVAADNSGVSGYAI----SLMATDLPTFNESFYCFHELWRGPLEGVVFVYIIYQLIGW 229
            :.|.:|  :...|..:.|..:    :|:|.|.......|:....|:..|::.:|.:.::|.|:|.
Zfish   409 FNKIMR--LCTSNLSMGGMTVGQICNLVAIDTNQLMWFFFLCPNLFAMPVQIIVGIILLYYLLGI 471

  Fly   230 PAVVGLGTIVAFIPLQAWAARAIARYKRSSADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIG 294
            .|::|...|....|:|.:.|..::..::|:.:...||:|..||::..::|:|:||||..|...:.
Zfish   472 SALIGATIITLLAPVQYFVATKLSDAQKSTLEYSSERLKKTNELLRGIKLLKLYAWEHIFCSNVE 536

  Fly   295 KVRKEEMDSIRGSTYIYAGLQCTGMISKLSLFLS--------LVTYV----FTGDIVTSQKVFIV 347
            :.|.:|:.|          ||...:.:.:|:|::        |||:|    .:.|...|..|...
Zfish   537 ETRCKELTS----------LQAFALYTSISIFMNTAIPIAAVLVTFVAHVHLSDDADLSPAVAFA 591

  Fly   348 ASYYDHLNDSLLHSWPLAINMWVETFVVANRVKDFLFQHENPADGGV-------------HNFKE 399
            :....|:..:.|......:...|:..|...::.:|....|   .||.             ||..:
Zfish   592 SLSLFHILVTPLFLLSSVVRSTVKALVSVQKLSEFFSCDE---IGGEQEPRATVVPNSTNHNKYQ 653

  Fly   400 A-------EDNP--EHGNFFGRTHKPKAEVKSITVHKLSA-------SWDQKKQEKRHRHIEDVS 448
            |       ...|  |..|.|....:.:.||.::....:..       ||.:....     :.:|:
Zfish   654 ALPLKVVNRKRPVREDWNSFALQSEQEDEVLAVGDEDICIKITNGYFSWTEGTST-----LSNVN 713

  Fly   449 FQAQDQQFVGIVGTVGAGKSTLLQVILGELDIISGSVEVN------------------------- 488
            .:....|...|||.||.|||:||...|||:..|||:|..|
Zfish   714 IKIPFGQLTMIVGQVGCGKSSLLLAALGEMQKISGTVIWNRMPTLDAEGNESLPDAAAEGDIRKR 778

  Fly   489 GVLSYAPQEPWLLRGSLRDNILFTEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSG 553
            |.::||.|:||||..:|.:||.|..|..:|||..|:..|.|..|::.||.||.|.:||.|..|||
Zfish   779 GAVAYASQKPWLLNTTLAENITFEMPLIKQRYRAVIEACSLQPDIDILPQGDQTIIGERGIILSG 843

  Fly   554 GQKARVSLARAVYRKADIYLLDDPLSAVDSHVSKMLLDRCLNEFL--SKKIRILVTHRVQLLRHV 616
            ||:.|:|:|||:|:..::..||||.||:|.|:|..|:...:.:.|  .|:..::|||::|.|.|.
Zfish   844 GQRQRISVARALYQTTNVVFLDDPFSALDIHLSDHLMQEGILKLLREEKRTVVIVTHKLQYLPHA 908

  Fly   617 DHLVLLEGGRISVQGH-----------YDALKKLI-----RFRMSVAND----VEVAKLR----- 656
            |.::.::.|.|..:|.           ::..|.|:     .|.....::    :|...||
Zfish   909 DWIIAMKDGSIQTEGTLKDIQKSQPELFEQWKTLMHRQDKEFEKETVDENMTVLERKNLRRAMYS 973

  Fly   657 --AMRTDSVYEEPEPRKSLSQEEHMDRHEIEQQFKEQQQIGSVKLQTYKEYFKVLGHPLVVVLIL 719
              |::|    ||.|..:||..:   |...:.|..:.:..|......||.....:    |:::|:|
Zfish   974 REALKT----EEDEEEESLESD---DDDNLSQVMRHRATIPWRSCGTYLSSAGL----LLLLLLL 1027

  Fly   720 LMFVVARSSEATMDIFLSKWAT---WEETEPNQH-----EPIPEYHRTRLRMMILYTFLILCTL- 775
            |..::..|....:|.:|:.|.:   ..:.:...|     :.|...|.:     .|..|.:||.|
Zfish  1028 LSQLLKHSLLVAIDYWLAHWTSKVITAKIDAAAHNCSLVQDIGFTHSS-----YLLVFSLLCCLG 1087

  Fly   776 IFYVLRTFGFFMMT-LRISLRIHDQLFQGVIRAFMHFFTLATSGRILNRFSSDVLAIDVNLP--- 836
            |...|.|......| ||::..:|..|...:|.|.|..|.....|.||||||||...||.::|
Zfish  1088 IVLCLATSVAVEWTGLRVAKELHHNLLSNIILAPMRLFETTPLGSILNRFSSDTNTIDQHIPATL 1152

  Fly   837 QAMMDSIEFAVNALAVLAVVSTANIWLLIPATVVVALLYGCRCLYIG-----ASRSLKRIETISR 896
            :.:..|....|:||.|::.|:...:.:|.|.|:.        |.:|.     ||:.|:::|..::
Zfish  1153 ECLSRSTLLCVSALGVISYVTPVFLIVLAPLTIA--------CYFIQKYFRVASKDLQQLEDSTQ 1209

  Fly   897 SPIYSHTNATFKGLATIRALN-GTKYMERDFHYYQNENTSALYLHVSINRAFAFWTDL------I 954
            .|:.||.:.|.:||.||||.. ..::.:|...:....|.::|:| .:.||    |.::      .
Zfish  1210 LPLLSHFSETVEGLTTIRAFRYEPRFRQRLLQFTDANNMASLFL-TAANR----WLEVRMEYIGA 1269

  Fly   955 CVLYILAVT------FSFLLFDKHRGYYSGDVGLAITQSMKLVLMCQAGMRQTVELENMMTSVER 1013
            |::.|.||.      :|.|        .:|.|||.:|.::.:.......:|...::|..:.:|:|
Zfish  1270 CIVLIAAVASITNSLYSHL--------STGLVGLGLTYALMVSNYLNWMVRNLADMEVQLGAVKR 1326

  Fly  1014 VMEYVNIPSEPA-YETEESVN-LPKHWPSGGQLDFRDLRLRYSNHGPYILKGLTFTIRGEEKIGI 1076
            :...:.  :||. ||...|.: :|:.||..|::..::|.:||.:....:||.:...|:..:|:||
Zfish  1327 IKALLR--TEPENYEGLLSASQVPEGWPQQGEIQIQNLSVRYDSTLKPVLKHVNAHIKPGQKLGI 1389

  Fly  1077 VGHTAAGKSSIVHALFRLAH-INGHISIDGFETSQLGLHDLRRRISIIPQDPVLFSGSLRFNLDP 1140
            .|.|.:||||...|.||:.. ..|.|.||..:.::|.|..||.|.|||.|||.||||::||||||
Zfish  1390 CGRTGSGKSSFSLAFFRMVDTFEGRIIIDDIDIAKLPLQTLRSRFSIIQQDPFLFSGTIRFNLDP 1454

  Fly  1141 FEEKTDEELWLALEAVKLKEFVSNLKDGINCRLHDCGANFSMGQRQLVCLARALLRQNKILIMDE 1205
            ..:.||..||.|||..:||..|..|..|::..:.:.|.|||.|||||.|||||.:|::.||||||
Zfish  1455 EMKATDSMLWEALEIAQLKPVVKTLPGGLDAIITEGGENFSQGQRQLFCLARAFVRKSSILIMDE 1519

  Fly  1206 ATANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGRVVELGHPHELLHNRHG 1270
            |||::|..|::::|:.:.|.||..||:|||||:||:::.|.|:|:..|.::|...|..||.....
Zfish  1520 ATASIDMATESILQKVVMTAFADRTVVTIAHRVHTILNADLVIVMKRGVILEFDKPEVLLDQEDS 1584

  Fly  1271 YLHRFV 1276
            ....||
Zfish  1585 VFASFV 1590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	405/1426 (28%)
		ABC_membrane	92..358	CDD:294371	73/300 (24%)
		ABCC_MRP_domain1	423..626	CDD:213217	80/236 (34%)
		ABC_membrane	762..988	CDD:294371	72/248 (29%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	100/219 (46%)
abcc8	XP_005170744.1	MRP_assoc_pro	39..1591	CDD:188098	407/1436 (28%)
		ABC_membrane	<388..603	CDD:294371	51/226 (23%)
		P-loop_NTPase	693..918	CDD:304359	80/229 (35%)
		ABC_membrane	1038..1307	CDD:279056	78/294 (27%)
		P-loop_NTPase	1355..1594	CDD:304359	105/236 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586051
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740