DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and ABCD

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_001245409.1	Gene:	ABCD / 43772	FlyBaseID:	FBgn0039890	Length:	730	Species:	Drosophila melanogaster

Alignment Length:	774	Identity:	155/774 - (20%)
Similarity:	270/774 - (34%)	Gaps:	228/774 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VHEQRQPNPVTKANFFSKWFFIWTREILVKGLQ------RNLDPSDLYETE---------PSLES 53
            :.|:.:.|..||..|.   :.:.|..||...::      :|::.:....|:         ||...
  Fly    11 IAEKCEHNGFTKHAFS---YALVTSAILALTIKVTIPYVKNVNTTSSVRTQKGKTNGQLSPSTRD 72

  Fly    54 TQVSSFLLGHWE-----QELKRSKPN-------------VLRMIFKAYGWSFVPASIVYSIMAIA 100
            :....|.|...|     |:||:...|             .|:|:.|.    .:|.:..|....::
  Fly    73 SSEEDFKLAEAEKLLVAQQLKKKATNNLVEPGLNKEFLKHLQMLAKI----MIPQAFCYETGLLS 133

  Fly   101 VHT-----------TQPLMLGGLVSFFSESTGKITKHSAYLYAM------GVVLCSLISGLFFHP 148
            |||           ....:.|.||.|       |.:.....:|:      |:.    |...|.:.
  Fly   134 VHTFCLISRTFLSIYVAALEGALVKF-------IVRKDIKQFALVLLKWFGIA----IPATFVNS 187

  Fly   149 FMKYLFRVGSRVRLACAGLVYRKFLRVSVAADN----SGVSG---YAISLMATDLPTFNESFYCF 206
            .:::|   .|::.||....:.|...|:.....|    |.:.|   .|...:..|:..|..|....
  Fly   188 MIRFL---ESKLSLAFRTRLVRHSYRLYFKNQNYYRVSNLDGRIENADHRLTEDISVFANSVAHL 249

  Fly   207 HELWRGPLEGVVFVYIIY---------QLIGWPAVVGLGTIVAFIPLQAWAARAIA--------- 253
            :.....|...::.:.:..         .:|..||:     .:..|.|.|...|.::
  Fly   250 YSSLTKPCFDLMLIGLALMRSSKKMKANIITGPAL-----SIGVIALTAHILRIVSPKFGQLVSE 309

  Fly   254 ---RY-------------KRSSADVGDERVKLM------NEIIAAMQLI-KMYAW----EKSFAK 291
               ||             ....|..|..:|::.      |.::..|..| ....|    |:.|.|
  Fly   310 EANRYGYLRHIHSRIITNAEEIAFYGGHKVEMQQLRQAYNRLVNQMTTIFNQKLWFIMLEQFFMK 374

  Fly   292 LIGKVRKEEMDSIRGSTYIYAGLQCTGMISKLSLFLSLVTYVFTGD------------------- 337
                             |:::|   ||||     .:||.  :.||.
  Fly   375 -----------------YVWSG---TGMI-----MVSLP--ILTGSDVGLGTVPNTAISESRVSE 412

  Fly   338 ----IVTSQKVFIVASYYDHLNDSLLHSWPLAINMWVETFVVANRVKDFLFQHENPADGGVHNFK 398
                :.|::.:.|.|:  |.: :.|:.|:...:::...||.||..:..|    |..|.|......
  Fly   413 RTQYLTTARNLLISAA--DAI-ERLMSSYKEIVSLAGYTFRVAGMMDVF----EETALGVYCKTS 470

  Fly   399 EAEDNPEHGNFFGRTHKPKAEVKSITVHKLSASWDQKKQEKRHRHIEDV-----------SFQAQ 452
            ..|.|..:|....|..||.|:.:.|      .|.|.|......|.:..|           :...:
  Fly   471 VMESNQSNGIIEFRNGKPIAKGRII------YSDDPKNMSISLRAVPVVTPNCDIVVPKLTLCIE 529

  Fly   453 DQQFVGIVGTVGAGKSTLLQVILGELDIISGSVEVN------GVLSYAPQEPWLLRGSLRDNILF 511
            ....:.|.|..|.|||:|.:::.|...|.:|.:.:.      ..:.|.||.|::..|||.|.|::
  Fly   530 PGVHLLITGPNGCGKSSLFRILSGLWPIYAGELHIPRPVKDVPCMFYIPQRPYMSIGSLCDQIIY 594

  Fly   512 TEPYD--------EQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLARAVYRK 568
            .:..:        |.....:|::..|:. :.|....|..|  :....||||:|.|:::||..|.:
  Fly   595 PDTREDMKRKHITENELRSILKMVSLEH-IAQRDSFDVVR--DWKDILSGGEKQRMAIARLFYHR 656

  Fly   569 ADIYLLDDPLSAVDSHVSKMLLDRCLNEFLSKKIRI---LVTHRVQLLRHVDHLVLLEG 624
            ....|||:..|||...|...:.:      ::|.:.|   .:|||..|.::..|::..:|
  Fly   657 PRYALLDECTSAVSIDVESSIYE------IAKGMGITLLTITHRPTLWKYHTHILEFDG 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	154/769 (20%)
		ABC_membrane	92..358	CDD:294371	60/357 (17%)
		ABCC_MRP_domain1	423..626	CDD:213217	55/230 (24%)
		ABC_membrane	762..988	CDD:294371
		ABCC_MRP_domain2	1042..1261	CDD:213211
ABCD	NP_001245409.1	3a01203	75..715	CDD:273360	143/707 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1117
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.860