DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG11898 and ABCC1

DIOPT Version :9

Sequence 1:NP_651679.2 Gene:CG11898 / 43451 FlyBaseID:FBgn0039645 Length:1320 Species:Drosophila melanogaster
Sequence 2:XP_016878726.1 Gene:ABCC1 / 4363 HGNCID:51 Length:1549 Species:Homo sapiens


Alignment Length:1402 Identity:455/1402 - (32%)
Similarity:712/1402 - (50%) Gaps:197/1402 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 VHEQRQPNPVTKANFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLGHWEQEL 68
            :|:. .|.|.:.|:|.|:..|.|...::|:|.::.|:.|||:.......|.||...|:.:|::|.
Human   220 IHDP-NPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKEC 283

  Fly    69 KRSK-----------------------------------------PNVLRMIFKAYGWSFVPASI 92
            .:::                                         |::.::::|.:|..|     
Human   284 AKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYF----- 343

  Fly    93 VYSIMAIAVHT----TQPLMLGGLVSFFSESTGKITKHSAYLYAMGVVLCSLISGLFFHPFMKYL 153
            :.|....|:|.    :.|.:|..|:.|.:::  |......|.|.:.:.:.:.:..|..|.:....
Human   344 LMSFFFKAIHDLMMFSGPQILKLLIKFVNDT--KAPDWQGYFYTVLLFVTACLQTLVLHQYFHIC 406

  Fly   154 FRVGSRVRLACAGLVYRKFLRVSVAADNSGVSGYAISLMATDLPTFNESFYCFHELWRGPLEGVV 218
            |..|.|::.|..|.||||.|.::.:|..|...|..::||:.|...|.:.....:.:|..||:.::
Human   407 FVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVIL 471

  Fly   219 FVYIIYQLIGWPAVVGLGTIVAFIPLQAWAARAIARYKRSSADVGDERVKLMNEIIAAMQLIKMY 283
            .:|:::..:|...:.|:..:|..:|:.|..|.....|:.:.....|.|:||||||:..::::|:|
Human   472 ALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLY 536

  Fly   284 AWEKSFAKLIGKVRKEEMDSIRGSTYIYA----GLQCTGMISKLSLFLSLVTYVFTGDIVTSQKV 344
            |||.:|...:..:|:||:..::.|.|:.|    ...||..:..|..|...|| :...:|:.:|..
Human   537 AWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVT-IDENNILDAQTA 600

  Fly   345 FIVASYYDHLNDSLLHSWPLAINMWVETFVVANRVKDFLFQHENPADGGVHNFKEAE-DNPEHGN 408
            |:..:.::.|... |:..|:.|:..|:..|...|::.|| .||           |.| |:.|.  
Human   601 FVSLALFNILRFP-LNILPMVISSIVQASVSLKRLRIFL-SHE-----------ELEPDSIER-- 650

  Fly   409 FFGRTHKPKAEVKSITVHKLSASWDQKKQEKRHRHIEDVSFQAQDQQFVGIVGTVGAGKSTLLQV 473
               |..|......||||...:.:|.:.....    :..::|...:...|.:||.||.|||:||..
Human   651 ---RPVKDGGGTNSITVRNATFTWARSDPPT----LNGITFSIPEGALVAVVGQVGCGKSSLLSA 708

  Fly   474 ILGELDIISGSVEVNGVLSYAPQEPWLLRGSLRDNILFTEPYDEQRYLEVLRVCHLDRDVEQLPL 538
            :|.|:|.:.|.|.:.|.::|.||:.|:...|||:||||....:|..|..|::.|.|..|:|.||.
Human   709 LLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPS 773

  Fly   539 GDSTRVGEGGASLSGGQKARVSLARAVYRKADIYLLDDPLSAVDSHVSKMLLDRCLNE--FLSKK 601
            ||.|.:||.|.:||||||.|||||||||..|||||.||||||||:||.|.:.:..:..  .|..|
Human   774 GDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNK 838

  Fly   602 IRILVTHRVQLLRHVDHLVLLEGGRISVQGHYDALKKLIRFRMSVANDVEVAKLRAMRTDSVYEE 666
            .||||||.:..|..||.::::.||:||..|.|..|         :|.|...|:.  :||.:..|:
Human   839 TRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQEL---------LARDGAFAEF--LRTYASTEQ 892

  Fly   667 PE------------PRKSLSQEEH-------------------------MDRH------------ 682
            .:            |.|...|.|:                         :.||            
Human   893 EQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEA 957

  Fly   683 EIEQQFK----EQQQIGSVKLQTYKEYFKVLGHPLVVVLILLMFVVARSSEATMDIFLSKWATWE 743
            :.|:.:|    ::.|.|.|||..|.:|.|.:| ..:..|.:.:|:....|....:.:||.|.   
Human   958 KKEETWKLMEADKAQTGQVKLSVYWDYMKAIG-LFISFLSIFLFMCNHVSALASNYWLSLWT--- 1018

  Fly   744 ETEPNQHEPIPE--YHRTRLRMMILYTFLILCTLIFYVLRTFGFFMMT----LRISLRIHDQLFQ 802
                  .:||..  ...|::|:.: |..|    .|...:..||:.|..    :..|..:|..|..
Human  1019 ------DDPIVNGTQEHTKVRLSV-YGAL----GISQGIAVFGYSMAVSIGGILASRCLHVDLLH 1072

  Fly   803 GVIRAFMHFFTLATSGRILNRFSSDVLAIDVNLPQAM---MDSIEFAVNALAVLAVVSTANIWLL 864
            .::|:.|.||....||.::||||.::..:|..:|:.:   |.|: |.|....::.:::|....::
Human  1073 SILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSL-FNVIGACIVILLATPIAAII 1136

  Fly   865 IPATVVVALLY-GCRCLYIGASRSLKRIETISRSPIYSHTNATFKGLATIRALNGTKYMERDFHY 928
            ||.   :.|:| ..:..|:.:||.|||:|::||||:|||.|.|..|::.|||.   :..||..|.
Human  1137 IPP---LGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAF---EEQERFIHQ 1195

  Fly   929 YQ---NENTSALYLHVSINRAFAFWTDLI--CVLYILAVTFSFLLFDKHRGYYSGDVGLAITQSM 988
            ..   :||..|.|..:..||..|...:.:  |::...|:   |.:..:| ...:|.|||:::.|:
Human  1196 SDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAAL---FAVISRH-SLSAGLVGLSVSYSL 1256

  Fly   989 KLVLMCQAGMRQTVELENMMTSVERVMEYVNIPSEPAYETEESVNLPKHWPSGGQLDFRDLRLRY 1053
            ::.......:|.:.|:|..:.:|||:.||.....|..::.:|:.. |..||..|:::||:..|||
Human  1257 QVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAP-PSSWPQVGRVEFRNYCLRY 1320

  Fly  1054 SNHGPYILKGLTFTIRGEEKIGIVGHTAAGKSSIVHALFRL-AHINGHISIDGFETSQLGLHDLR 1117
            .....::|:.:..||.|.||:||||.|.|||||:...|||: ....|.|.|||...:::||||||
Human  1321 REDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLR 1385

  Fly  1118 RRISIIPQDPVLFSGSLRFNLDPFEEKTDEELWLALEAVKLKEFVSNLKDGINCRLHDC---GAN 1179
            .:|:||||||||||||||.|||||.:.:|||:|.:||...||:|||.|.|.::   |:|   |.|
Human  1386 FKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLD---HECAEGGEN 1447

  Fly  1180 FSMGQRQLVCLARALLRQNKILIMDEATANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDN 1244
            .|:||||||||||||||:.|||::|||||.||.|||:|||..|.|:|..||||||||||:|:||.
Human  1448 LSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDY 1512

  Fly  1245 DRVMVVDMGRVVELGHPHELLHNRHGYLHRFVEKTGV 1281
            .||:|:|.|.:.|.|.|.:||..| |..:...:..|:
Human  1513 TRVIVLDKGEIQEYGAPSDLLQQR-GLFYSMAKDAGL 1548

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG11898NP_651679.2 CFTR_protein 9..1268 CDD:273530 451/1382 (33%)
ABC_membrane 92..358 CDD:294371 70/273 (26%)
ABCC_MRP_domain1 423..626 CDD:213217 90/204 (44%)
ABC_membrane 762..988 CDD:294371 69/238 (29%)
ABCC_MRP_domain2 1042..1261 CDD:213211 127/222 (57%)
ABCC1XP_016878726.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165151520
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.650

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