DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG11898 and CG5789

DIOPT Version :9

Sequence 1:NP_651679.2 Gene:CG11898 / 43451 FlyBaseID:FBgn0039645 Length:1320 Species:Drosophila melanogaster
Sequence 2:NP_001247286.1 Gene:CG5789 / 42928 FlyBaseID:FBgn0039207 Length:1402 Species:Drosophila melanogaster


Alignment Length:1459 Identity:520/1459 - (35%)
Similarity:777/1459 - (53%) Gaps:216/1459 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSAVHEQRQPNPVTKANFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLGHWE 65
            |.:..:..:.||...||..|:..|.|...:|.:|.:|.|:..||.:......|.|:...|...|.
  Fly     1 MDSSAKPTRKNPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWF 65

  Fly    66 QELKRS-----KPNVLRMIFKAYGWSFVPASIVYSIMA---IAVHTTQPLMLGGLVSFF------ 116
            :||:||     ||::...:|:.    |:..:|:..::.   |.:.|..|.:|..|:..|      
  Fly    66 KELERSHRKKQKPHLRNALFRC----FLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVA 126

  Fly   117 ------------SESTGKITK-------------------------------------------- 125
                        |:|..:..:                                            
  Fly   127 QLRNIDVNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVD 191

  Fly   126 HSAY----------------LYAMGVVLCSLISGLF-----FHPFMKYLFRVGSRVRLACAGLVY 169
            |:|.                :.::|.||  ::|.||     .|..::... :|:|:|:||..|:|
  Fly   192 HNATAVRSILDQTVEHMWNDMNSLGAVL--VLSTLFCCFLLHHVDLRQRL-MGARMRIACCSLIY 253

  Fly   170 RKFLRVSVAADNSGVSGYAISLMATDLPTFNESFYCFHELWRGPLEGVVFVYIIYQLIGWPAVVG 234
            ||.||:|:.......:||.|:|::.|:...:..|...|.:|..||:.::..|:|:..||.||:||
  Fly   254 RKTLRLSMKTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVG 318

  Fly   235 -LGTIVAFIPLQAWAARAIARYKRSSADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRK 298
             :|.::..:|:|...::..:..:...|:..|.||.:|||::..:|:||||||||.|..::.:.|:
  Fly   319 VVGLLLKTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARR 383

  Fly   299 EEMDSIRGSTYIYAGLQCTGMI--SKLSLFLSLVTYVFTGDIVTSQKVFIVASYYDHLNDSLLHS 361
            .|:..||.::|: .|...:.|:  .:.:|:::|......|..:|:..||..||||:.|.......
  Fly   384 SEIKQIRYASYL-RGFYLSTMVFTERSTLYITLAAAALMGQTITADFVFSAASYYNILQLVAAIW 447

  Fly   362 WPLAINMWVETFVVANRVKDFLFQHENPADGGVHNFKEAEDNPEHGNFFGRTHKPKAE---VKSI 423
            :|||::...|..|...|::|||.            .:..|:..:     |.|||...|   .:::
  Fly   448 YPLAVSFGAEALVSLRRIQDFLM------------LEGREERTQ-----GLTHKRDQEGGDSRAV 495

  Fly   424 TVHKLSASWDQKKQEKRHRHIEDVSFQAQDQQFVGIVGTVGAGKSTLLQVILGELDIISGSVEVN 488
            |:..::||||.:|.:|.   ::.::.|.:..|...::|.||||||::||::||||.:|.|.|.:.
  Fly   496 TIKDINASWDIEKPQKT---LQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQ 557

  Fly   489 GVLSYAPQEPWLLRGSLRDNILFTEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSG 553
            |.||||.|||||..||:|:||||.|.:|.:||.||.|.|.|..|.:|||.||.|.|||.||||||
  Fly   558 GDLSYAAQEPWLFTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSG 622

  Fly   554 GQKARVSLARAVYRKADIYLLDDPLSAVDSHVSKMLLDRCLNE----FLSKKIRILVTHRVQLLR 614
            ||:||:|||||||:.|.|||:||||||||:||.:.|.|..:..    ...|..||||||:|..|.
  Fly   623 GQRARISLARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRILVTHQVHFLS 687

  Fly   615 HVDHLVLLEGGRISVQGHYDALKKLIRFRMSVANDVEVAKLRAMRTDSVYEEPEPRKSLSQEEHM 679
            ..|.:|:::.|||..||.|..|         :.:|::.|:|    .:...||.|...|.:|...:
  Fly   688 EADVIVIVDQGRILRQGTYQEL---------INSDLDFARL----LERPKEEEEGENSRNQTSPL 739

  Fly   680 DRHEIE----------------QQFKEQ---------------------------QQIGSVKLQT 701
            ..:.:|                ||.::|                           |..|.:..:.
  Fly   740 SVNSLESDDEDIPFIDGVKDGYQQLRKQSSSVHGSKSLDSTQLDDNVDEDDLAEAQASGGISPRV 804

  Fly   702 YKEYF----KVLGHPLVVVLILLMFVVARSSEATMDIFLSKWATWEETEPNQHEPIPEYHRTRLR 762
            :.|||    .:|....:|.::::..||..||    |.|.:.| |.:|.:.:|.|..    .:...
  Fly   805 WYEYFHAGSTLLSFSFMVFVMVMSQVVCSSS----DFFANIW-TQQEHQRSQGEAT----FSTFE 860

  Fly   763 MMILYTFLILCTLIFYVLRTFGFFMMTLRISLRIHDQLFQGVIRAFMHFFTLATSGRILNRFSSD 827
            .|.:|..||:..:|....|.|.||.:.:..|..:||::|..::.|.|.||....|||||||||.|
  Fly   861 CMYIYGALIIAVVIMTTFRGFLFFKICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKD 925

  Fly   828 VLAIDVNLPQAMMDSIEFAVNALAVLAVVSTAN----IWLLIPATVVVALLYGCRCLYIGASRSL 888
            :.|||..||:||||.|:.|:....:|.|:...|    ..:|:.|.|.|.:|.    ||:..|:.|
  Fly   926 MGAIDELLPRAMMDFIQIALVMFGILIVIGILNPVLVAAMLVVAVVDVLILK----LYLRPSQDL 986

  Fly   889 KRIETISRSPIYSHTNATFKGLATIRALNGTKYMERDFHYYQNENTSALYLHVSINRAFAFWTDL 953
            ||:|.|.|||::||.:|:..|||.||:......:.::|...|:.::|...|.:::|.....|.|.
  Fly   987 KRLEGICRSPVFSHLSASLTGLAIIRSRQLQDVVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDC 1051

  Fly   954 ICVLYILAVTFSFLLFDKHRGYYSGDVGLAITQSMKLVLMCQAGMRQTVELENMMTSVERVMEYV 1018
            :..:::.:|||||::..:..  |||:|||||.|:|.|..|.|.|:||..|....|||||||::|.
  Fly  1052 VSCIFLTSVTFSFIISSETT--YSGNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYT 1114

  Fly  1019 NIPSEPAYETEESVNLPKHWPSGGQLDFRDLRLRYSNHGPYILKGLTFTIRGEEKIGIVGHTAAG 1083
            .:..|||...:..   |:.||:.||::||::..||..:|..:|:.|..||....|:||||.|.||
  Fly  1115 ELEQEPALGEKTP---PQQWPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAG 1176

  Fly  1084 KSSIVHALFRLAHINGHISIDGFETSQLGLHDLRRRISIIPQDPVLFSGSLRFNLDPFEEKTDEE 1148
            |||::.||||||||.|.|.|||.||..:.|..||.|||||||||||||.::|:||||||..||.|
  Fly  1177 KSSLIGALFRLAHIEGEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAE 1241

  Fly  1149 LWLALEAVKLKEFVSNLKDGINCRLHDCGANFSMGQRQLVCLARALLRQNKILIMDEATANVDPE 1213
            ||.|||.|:|::.:    .|::..:.:.|.|||:|||||:|||||:||.||:|::|||||||||:
  Fly  1242 LWSALEDVELRKAI----PGLDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQ 1302

  Fly  1214 TDNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGRVVELGHPHELLHNRHGYLHRFVEK 1278
            ||.|||..|..||..|||||:|||||||||:||::|:|.|..||...|:.||....|:|.:.||.
  Fly  1303 TDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHLRQMVEA 1367

  Fly  1279 TGVGTAQHLRHLAEQSYRKRVLGRKSEDQ 1307
            || |.::.|:..|..|:::....|...|:
  Fly  1368 TG-GESEALKKTASDSHKRMQRERDERDR 1395

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG11898NP_651679.2 CFTR_protein 9..1268 CDD:273530 507/1410 (36%)
ABC_membrane 92..358 CDD:294371 86/354 (24%)
ABCC_MRP_domain1 423..626 CDD:213217 105/206 (51%)
ABC_membrane 762..988 CDD:294371 86/229 (38%)
ABCC_MRP_domain2 1042..1261 CDD:213211 128/218 (59%)
CG5789NP_001247286.1 CFTR_protein 9..1367 CDD:273530 510/1420 (36%)
ABC_membrane 214..441 CDD:294371 74/230 (32%)
ABCC_MRP_domain1 495..699 CDD:213217 105/206 (51%)
ABC_membrane 863..1088 CDD:294371 87/230 (38%)
ABCC_MRP_domain2 1135..1350 CDD:213211 128/218 (59%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 50 1.000 Domainoid score I4365
eggNOG 1 0.900 - - E2759_KOG0054
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 133 1.000 Inparanoid score I246
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 1 1.000 - - FOG0001028
OrthoInspector 1 1.000 - - otm14754
orthoMCL 1 0.900 - - OOG6_100026
Panther 1 1.100 - - P PTHR24223
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
98.870

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