Protein Alignment CG11898 and CG10226

DIOPT Version :9

• Sequence 1: NP_651679.2
• Gene: CG11898 / 43451
• FlyBaseID: FBgn0039645
• Length: 1320
• Species: Drosophila melanogaster
• Sequence 2: NP_648040.1
• Gene: CG10226 / 38725
• FlyBaseID: FBgn0035695
• Length: 1320
• Species: Drosophila melanogaster
• Alignment Length: 1397
• Identity: 310/1397 - (22%)
• Similarity: 571/1397 - (40%)
• Gaps: 313/1397 - (22%)

  Fly    66 QELKRSKPNVLRMIFKAY--------GW-------SFVPA---SIVYSIMAIAVHTTQPLMLGGL 112
            |:.|::|.....|:  :|        ||       .||.|   |:|:.| ||.|::.       |
  Fly    23 QKKKKTKEKAQPMV--SYTELFRYIAGWDYLVLLSGFVAAFLQSLVFPI-AIVVYSE-------L 77

  Fly   113 VSFFSEST-----------------GKITKHSAY----------LYAMGVV-----LCSLISGLF 145
            |:.|.|.|                 |||..:::|          ..:.|::     |..|.||::
  Fly    78 VAMFIERTLGQGTSSVTIGLSLFGGGKILTNASYEENMQELRKDSVSFGILMTLNTLLMLFSGVY 142

  Fly   146 F-HPFMKYLFRVGSRVRLACAGLVYRKFLRVSV------------------AADN-----SGVS- 185
            : ..|.:...::..|:|        |:|.:.::                  ..||     ||::
  Fly   143 YVDAFNRLALKLTVRMR--------REFFKATLRQEIGWHDMAKDQNFAVRITDNMEKIRSGIAE 199

  Fly   186 --GYAISLMATDLPTFNESFYCFHELWRGPLEGVVFVYIIYQLIGWPAVVGLGTIVAFIPLQAWA 248
              |:.:.:|.                      .|:...::..:.||...:   .||.:|||....
  Fly   200 NLGHYVEIMC----------------------DVIISVVLSFIYGWKLAL---AIVFYIPLTLVV 239

  Fly   249 ARAIARYKRSSADVGDER------VKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDS--IR 305
            ..|:|.|:...  .|.|:      ..::.|:|.|::.:..:..|:|.:.....:.|..:.:  .:
  Fly   240 NSAVAHYQGKL--TGQEQSSYVRASSVVEEVIGAIRTVVAFGGERSESLRYDSLLKPALKAGKWK 302

  Fly   306 GSTYIYAGLQCTGMISKLSLFL----------SLVTYVFTGDIVTSQK------VFIVASYYDHL 354
            |:   ::||..|  :.|..||:          :|:.|.....|...::      |.||.|.....
  Fly   303 GA---FSGLSDT--VMKAMLFITGAGSFWYGANLILYYRDPSIPIDEREYTPAVVMIVISGIIVS 362

  Fly   355 NDSLLHSWPLAINMWVETFVVANRVKDFLFQHENPADGGVHNFKEAEDNPEHGNFFGRTH--KPK 417
            .:.:..:.|     ::|||.:|.              |......:..|         ||.  .|.
  Fly   363 ANQISRTSP-----FLETFAMAR--------------GSASAILDVID---------RTSLIDPL 399

  Fly   418 AEVKSITVHKLSASWDQKKQEKRHRHIEDV------SFQAQDQQFVGIVGTVGAGKSTLLQVILG 476
            ::...|..:.|..:.:.:....|:...|||      :...::.|.|.:||..|.||||.:|::..
  Fly   400 SKAGKILNYGLKGAVEFRDVFFRYPAREDVIVLRGLNVVVEEGQTVALVGPSGCGKSTCIQLLQR 464

  Fly   477 ELDIISGSVEVNGV-------------LSYAPQEPWLLRGSLRDNILFTEPYDEQRYLE-VLRVC 527
            ..|.:.|.|.::|.             ::...|||.|.:||:.:||...:|...|:.:| ..:..
  Fly   465 FYDPVFGQVLLDGEDVRKYNIKWLRSNIAVVGQEPVLFQGSIGENIRHGKPEATQKEVEDAAKAA 529

  Fly   528 HLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLARAVYRKADIYLLDDPLSAVDSHVSKMLLDR 592
            :....:..|..|..|.:.|.|..|||||:.|:::|||:.::..|.|||:..||:|.| |:.|:..
  Fly   530 NAHDFIIALHKGYDTDISEKGVQLSGGQRQRIAIARALIQQPKILLLDEATSALDYH-SEKLVQA 593

  Fly   593 CLNEFLSKKIRILVTHRVQLLRHVDHLVLLEGGRISVQGHYDALKKLIRF--RM----------- 644
            .|::....:..::|:||:..:||...:|.:|.|:...||.::.|.||..|  :|
  Fly   594 ALDKACKGRTTLVVSHRLSAIRHAHRIVYIENGKAVEQGTHEELMKLEGFYHKMVTVHSYDDSAE 658

  Fly   645 SVANDV-EVAKLRAMRTDSVYEEPEP-----RKSLSQEEHMDRHEIEQQFKEQQQIGSVKLQT-- 701
            .:.|:: |||:::..:   :..|.||     |.|:...|    ...|.|.|....:.::.:..
  Fly   659 ELLNELEEVAEIKERK---MSYEVEPYQLGTRNSIVSLE----KNAEFQMKNLNGLANITMNQEI 716

  Fly   702 ----------YKEYFKVLG--HPLVVVLILLMFVVARSSEATMDIF----------LSKWATWEE 744
                      ...:|::||  .|....|| :..:.|.....||.:|          |:|
  Fly   717 DDPRVPSANFISTFFRILGWARPEWSFLI-IGAICAGLYGVTMPVFSVVLAELYGSLAK------ 774

  Fly   745 TEPNQHEPIPEYHRTRLRMMILYTFLILCTLIFYVLRTFGFFMMTLRISLRIHDQLFQGVIRAFM 809
              |...|.:.:    ...|.|:...:.:...:...::||.|.:..:.::.|:..:.|:.::...|
  Fly   775 --PTDEEVLEQ----SASMAIISLVIGIAAGVVCYIQTFFFNLAGVWLTTRMRSKTFRCIMNQEM 833

  Fly   810 HFFTLATS--GRILNRFSSDVLAIDVNLPQAMMDSIEFAVNALAVLAVV-----STANIWLLIPA 867
            .:|....:  |.:..|.|.|..::...:...:.:.|:...|.:..:|:.     ..|.|.|....
  Fly   834 GWFDRKENSIGALSARLSGDAASVQGAIGFPLSNIIQAFTNFICSIAIAFPYSWELALICLSTSP 898

  Fly   868 TVVVALLYGCRCLYIGASRSLKRIETISR-SPIYSHTNATFKGLATIRALNGTKYMERDFHYYQN 931
            .:|.::::..|   .|...:||..|.:.. |.|.:.|      :..||.:.|.:..|.....|..
  Fly   899 FMVASIVFEAR---FGEKSALKEKEVLEETSRIATET------ITQIRTVAGLRREEELIKIYDK 954

  Fly   932 ENTSALYLHVSINRAFAFWTDLICVLYILAVTFSFLLFDKHRGYYSGDVGLAITQSMK------- 989
            |  ...|.|..::|  ..|..|:..|....:.|.:.:...:.|:...|..:.....||
  Fly   955 E--VERYRHQILSR--LKWRGLVNSLGKSLMFFGYAVTLTYGGHMCADGKIKFETIMKISNTMLY 1015

  Fly   990 -LVLMCQAGMRQTVELENMMTSVERVMEYVN----IPSEPAYETEESVNLPKHWPSGGQ--LDFR 1047
             |.::.|: :..|......:.|..|:.|.::    |.|..::|.:::.|...:..:..|  :.:|
  Fly  1016 GLFILAQS-LAFTPAFNAALLSANRMYEIIDRKPQIQSPESFEIQQNGNGTAYKTNVVQQGVSYR 1079

  Fly  1048 DLRLRYSNHGPYI--LKGLTFTIRGEEKIGIVGHTAAGKSSIVHALFRLAHIN-GHISIDGFETS 1109
            .|...|.:. |:|  |:.....|...:.:.:||.:.:|||:.|..|.|....: |.|.||  :.|
  Fly  1080 GLNFSYPSR-PHIKVLQNFNLDINQGQTVALVGASGSGKSTCVQLLMRYYDPDEGKILID--QES 1141

  Fly  1110 ---QLGLHDLRRRISIIPQDPVLFSGSLRFNLDPFEEKTDEELWLALEAVKL---KEFVSNLKDG 1168
               .:.|..||||:.|:.|:|.||..|:..|:...:......:...:||.|:   .||:.:|...
  Fly  1142 IHHDMDLKTLRRRLGIVSQEPSLFEKSIADNIGYGDTSRQVPMQQIIEAAKMANAHEFIMSLPAQ 1206

  Fly  1169 INCRLHDCGANFSMGQRQLVCLARALLRQNKILIMDEATANVDPETDNLIQEAIHTKFAHCTVLT 1233
            .:..|...|...|.||:|.:.:|||::|..|||::||||:.:|.:::.::|:|:.:..:..|.:.
  Fly  1207 YDTVLGSKGTQLSGGQKQRIAIARAMVRNPKILLLDEATSALDFQSERVVQQALDSACSGRTCIV 1271

  Fly  1234 IAHRLHTVMDNDRVMVVDMGRVVELGHPHELL 1265
            |||||.|:.:.:.:.|:..|::||.|...:||
  Fly  1272 IAHRLSTIQNANVICVIQAGKIVEQGSHSQLL 1303

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	310/1397 (22%)
		ABC_membrane	92..358	CDD:294371	63/348 (18%)
		ABCC_MRP_domain1	423..626	CDD:213217	63/222 (28%)
		ABC_membrane	762..988	CDD:294371	43/233 (18%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	71/229 (31%)
CG10226	NP_648040.1	PTZ00265	81..1311	CDD:240339	292/1329 (22%)
		ABC_membrane	<147..333	CDD:279056	38/225 (17%)
		ABC_MTABC3_MDL1_MDL2	414..649	CDD:213216	69/235 (29%)
		ABC_membrane	749..1019	CDD:279056	54/294 (18%)
		ABC_MTABC3_MDL1_MDL2	1076..1316	CDD:213216	72/231 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910