DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and abcc4

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_001007039.2	Gene:	abcc4 / 368620	ZFINID:	ZDB-GENE-030616-511	Length:	1331	Species:	Danio rerio

Alignment Length:	1339	Identity:	480/1339 - (35%)
Similarity:	766/1339 - (57%)	Gaps:	77/1339 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSAVHEQRQPNPVTKANFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLGHWE 65
            |..:.:..:.||...||.||:.||.|...:...|.:|.|:..|::...|...|.::...|..:|:
Zfish     5 MEPIKKDAKSNPSASANLFSQIFFCWLNPLFSIGSKRRLEEDDMFNVLPEDRSKKLGEELQSYWD 69

  Fly    66 QELKRS-----KPNVLRMIFKAYGWSFVPASIVYSIMAIAVHTTQPLMLGGLVSFFSESTGKITK 125
            ||.:::     .|.:.:.|.:.| |.......|::::..::...||:.||.|:.:|..     .:
Zfish    70 QEKEKAAKELKTPKLTKAIIRCY-WKSYAVLGVFTLIEESIKVIQPVFLGKLIKYFEN-----YR 128

  Fly   126 H-------SAYLYAMGVVLCSLISGLFFHPFMKYLFRVGSRVRLACAGLVYRKFLRVSVAADNSG 183
            |       .||.||.||.|.:|...|..|.:..::.|.|.::|:|...::|||.|.:|.||....
Zfish   129 HDDMAALSEAYGYATGVCLSTLGLALLHHLYFYHVQRAGMKIRIAMCHMIYRKALCLSAAAMGQT 193

  Fly   184 VSGYAISLMATDLPTFNESFYCFHELWRGPLEGVVFVYIIYQLIGWPAVVGLGTIVAFIPLQAWA 248
            .:|..::|::.|:..|:|.....|.||.|||:....:.:::|.||...:.|:..:|..:|||...
Zfish   194 TTGQIVNLLSNDVNKFDELTIFLHFLWVGPLQAAAVIGLLWQEIGPSCLAGMAVLVFLMPLQTMF 258

  Fly   249 ARAIARYKRSSADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIRGSTYIYAG 313
            .:..::|:..:|.:.|.|::.|||:::.:::||||||||.||.|:..||::|:..|..|:|: .|
Zfish   259 GKLFSKYRSKTAALTDSRIRTMNEVVSGIRIIKMYAWEKPFAMLVNDVRRKEISKIMSSSYL-RG 322

  Fly   314 LQCTGMI--SKLSLFLSLVTYVFTGDIVTSQKVFIVASYYDHLNDSLLHSWPLAINMWVETFVVA 376
            |......  :|:.||::...||..|:.:::.:||:..|.|..:..::...:|.||....|:.:..
Zfish   323 LNMASFFTANKIILFVTFTVYVLVGNTMSASRVFVAVSLYSAVRLTVTLFFPAAIEKVSESAISI 387

  Fly   377 NRVKDFLFQHENPADGGVHNFKEAEDNPEHGNFFGRTHKPKAEVK----SITVHKLSASWDQKKQ 437
            .|:|.||...|                      ..:.|.|.::.:    |:.:..|...||:...
Zfish   388 RRIKKFLLLDE----------------------LVKNHLPLSQEEKKEPSVEMQDLICYWDKTLD 430

  Fly   438 EKRHRHIEDVSFQAQDQQFVGIVGTVGAGKSTLLQVILGELDIISGSVEVNGVLSYAPQEPWLLR 502
            ...   :::|.|..:..|.:.::|.||||||:||..:||||....|.::|.|.|:||.|:||:..
Zfish   431 APT---LQNVCFTVKPGQLLAVIGPVGAGKSSLLSTVLGELPAEKGVIKVKGELTYASQQPWVFP 492

  Fly   503 GSLRDNILFTEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLARAVYR 567
            |::|.||||.:....|||..|||.|.|.||:|.||.||.|.:|:.||:|||||||||:||||||:
Zfish   493 GTIRSNILFGKELQPQRYERVLRACALKRDMELLPDGDLTVIGDRGATLSGGQKARVNLARAVYQ 557

  Fly   568 KADIYLLDDPLSAVDSHVSKMLLDRCLNEFLSKKIRILVTHRVQLLRHVDHLVLLEGGRISVQGH 632
            .||||||||||||||:.||:.|.::|:...|..|.||||||::|.|:..:.:::|:.|.:..:|.
Zfish   558 DADIYLLDDPLSAVDAEVSRHLFEQCVCGILKDKPRILVTHQLQYLKAANQILVLKEGHMVARGS 622

  Fly   633 YDALKKL-IRFRMSVANDVE------------VAKLRAMRTDSVYEEPEPRKSLSQE-EHMDRHE 683
            |..|::. :.|...:..|.|            ..:.|.:..:||........|:..: :.:....
Zfish   623 YSELQQSGLDFTSLLKKDEEEESGSEKGEAPRSPRSRTVSQNSVRSHSSSVLSVKDDSDQLPAEP 687

  Fly   684 IEQQFKEQQQIGSVKLQTYKEYFKVLGHPLVVVLILLMFVVARSSEATMDIFLSKWATWEE---- 744
            :....:|.:..|::.::.|.:||:...:.:::||:||:.::|::.....|.:||.|||.:|
Zfish   688 VHTMAEELRSEGNIGIRMYWKYFRAGANVVMLVLLLLLNLLAQTFYILQDWWLSYWATEQEKLDH 752

  Fly   745 ----TEPNQHEPIPEYHRTRLRMMI-LYTFLILCTLIFYVLRTFGFFMMTLRISLRIHDQLFQGV 804
                |..|.........:..|...: :|..|...|::|..:|....|...:..:..:|:::|..:
Zfish   753 NTNNTNTNNTSAGNTTQQLDLNFYLGIYAGLTGATIVFGFMRCLIMFNALVSSAEMLHNRMFNSI 817

  Fly   805 IRAFMHFFTLATSGRILNRFSSDVLAIDVNLPQAMMDSIEFAVNALAVLAVVSTANIWLLIPATV 869
            :|..:.||.:...||||||||.|:..:|..||...:|.|:..:..:.|:||.|:...|:|||...
Zfish   818 LRTPVRFFDINPIGRILNRFSKDIGHLDSLLPWTFVDFIQVFLQIVGVIAVASSVIPWILIPVLP 882

  Fly   870 VVALLYGCRCLYIGASRSLKRIETISRSPIYSHTNATFKGLATIRALNGTKYMERDFHYYQNENT 934
            ::......|..::..||.:||||:.:|||::||.:::.:||.||||....:..::.|..:|:.::
Zfish   883 LLICFLFLRRYFLRTSRDVKRIESTTRSPVFSHLSSSLQGLWTIRAFKAEERFQQTFDAHQDLHS 947

  Fly   935 SALYLHVSINRAFAFWTDLICVLYILAVTFSFLLFDKHRGYYSGDVGLAITQSMKLVLMCQAGMR 999
            .|.:|.::.:|.||...|.:|.:::....|..||......  :||||||::.::.|:.|.|.|:|
Zfish   948 EAWFLFLTTSRWFAVRLDGMCSVFVTITAFGCLLLKDTMN--AGDVGLALSYAVTLMGMFQWGVR 1010

  Fly  1000 QTVELENMMTSVERVMEYVNIPSEPAYETEESVNLPKHWPSGGQLDFRDLRLRYSNHGPYILKGL 1064
            |:.|:||||||||||:||..:.||..:||::..:  ..||:.|.:.|..:...||:.||.:||.:
Zfish  1011 QSAEVENMMTSVERVVEYTELESEAPWETQKRPS--PDWPNRGLITFDRVNFSYSSDGPVVLKNI 1073

  Fly  1065 TFTIRGEEKIGIVGHTAAGKSSIVHALFRLAHINGHISIDGFETSQLGLHDLRRRISIIPQDPVL 1129
            :...|..||:||||.|.|||||::.|||||:...|.|.:||..||::||||||:::|||||||||
Zfish  1074 SAMFRPREKVGIVGRTGAGKSSLISALFRLSEPEGKILVDGVLTSEIGLHDLRQKMSIIPQDPVL 1138

  Fly  1130 FSGSLRFNLDPFEEKTDEELWLALEAVKLKEFVSNLKDGINCRLHDCGANFSMGQRQLVCLARAL 1194
            |:|::|.|||||.:.:|.:||.|||.|:||..|..|...:...|.:.|:|||:|||||||||||:
Zfish  1139 FTGTMRKNLDPFNQHSDHDLWKALEEVQLKAAVEELPGKLETELAESGSNFSVGQRQLVCLARAI 1203

  Fly  1195 LRQNKILIMDEATANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGRVVELG 1259
            ||:|::||:|||||||||.||.|||:.|..||..||||||||||:|::|:||::|:|.||:.|..
Zfish  1204 LRKNRVLIIDEATANVDPRTDELIQKTIRDKFKECTVLTIAHRLNTIIDSDRILVLDAGRIHEYD 1268

  Fly  1260 HPHELLHNRHGYLHRFVEKTGVGTAQHLRHLAEQSYRKR 1298
            .||.||.|:.|..::.|::||...|..|...|:|:|..|
Zfish  1269 APHVLLQNQSGIFYKMVQQTGKAEATSLLQTAKQAYANR 1307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	468/1299 (36%)
		ABC_membrane	92..358	CDD:294371	84/274 (31%)
		ABCC_MRP_domain1	423..626	CDD:213217	97/202 (48%)
		ABC_membrane	762..988	CDD:294371	69/226 (31%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	123/218 (56%)
abcc4	NP_001007039.2	SunT	11..1289	CDD:331423	471/1313 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586021
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0001028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.750