DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and ABCC6

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	XP_024306029.1	Gene:	ABCC6 / 368	HGNCID:	57	Length:	1515	Species:	Homo sapiens

Alignment Length:	1357	Identity:	422/1357 - (31%)
Similarity:	659/1357 - (48%)	Gaps:	133/1357 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 EQRQPNPVTKANFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLGHWEQELKR 70
            :|..|.|.|.|.|.||..|.|...::.:|.:|.|.|.||:.......|.::.|.|...|.:....
Human   210 QQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMRNRSA 274

  Fly    71 SKPNVLRMIFKAYG---------------------------WSFVPASIVYSIMAIAVHTTQPLM 108
            ::.:...:.||..|                           |....::.:...:::.:.......
Human   275 ARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLSLIISDVFRFT 339

  Fly   109 LGGLVSFFSESTG--KITKHSAYLYAMGVVLCSLISGLFFHPFMKYLFRVGSRVRLACAGLVYRK 171
            :..|:|.|.|..|  |......||.|:.:.|.:.:..||....|..|..:..|:|.|..||||||
Human   340 VPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLKVLQMRLRSAITGLVYRK 404

  Fly   172 FLRVSVAADNSGVSGYAISLMATDLPTFNESFYCFHELWRGPLEGVV--FVYIIYQLIGWPAVVG 234
            .|.:|..:..:...|..::|::.|:....||....:.||. ||..:|  ||| ::||:|..|:..
Human   405 VLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWL-PLVWIVVCFVY-LWQLLGPSALTA 467

  Fly   235 LGTIVAFIPLQAWAARAIARYKRSSADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKE 299
            :...::.:||..:.::....::.......|.|.:|.:.|:...:.||.:.||.:|...:..:|.:
Human   468 IAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQ 532

  Fly   300 EMDSIRGSTYIYAGLQCTGMIS-KLSLFL-SLVTY----VFTGDIVTSQKVFIVASYYDHLNDSL 358
            |:.::|.|..:::    ..::| ::|.|| :||.:    :...:.:.::|.|:..:..:.||.:.
Human   533 ELGALRTSGLLFS----VSLVSFQVSTFLVALVVFAVHTLVAENAMNAEKAFVTLTVLNILNKAQ 593

  Fly   359 LHSWPLAINMWVETFVVANRVKDFLFQHENPADGGVHNFKEAEDNPEHGNFFGRTHKPKAEVKSI 423
            .. .|.:|:..|:..|..:|:..||...|  .|.||      .|:...|:..|:        ..|
Human   594 AF-LPFSIHSLVQARVSFDRLVTFLCLEE--VDPGV------VDSSSSGSAAGK--------DCI 641

  Fly   424 TVHKLSASWDQKKQEKRHRHIEDVSFQAQDQQFVGIVGTVGAGKSTLLQVILGELDIISGSVEVN 488
            |:|..:.:|.|:.....||    ::........:.:||.||||||:||..:||||..:.|.|.:.
Human   642 TIHSATFAWSQESPPCLHR----INLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIE 702

  Fly   489 GVLSYAPQEPWLLRGSLRDNILFTEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSG 553
            |.::|.|||.|:...|:.:|:.|.:..|......||..|.|..||:..|.|..|.:||.|.:|||
Human   703 GAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSG 767

  Fly   554 GQKARVSLARAVYRKADIYLLDDPLSAVDSHVSKMLLDRCLNE--FLSKKIRILVTHRVQLLRHV 616
            |||.|:||||||||||.:|||||||:|:|:||.:.:.::.:..  .|....||||||.:.:|...
Human   768 GQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQA 832

  Fly   617 DHLVLLEGGRISVQGHYDALKKLIRFRMSVANDVEV------------AKLRAMRTDSVYEEPEP 669
            |.:::|..|.|:..|.|..|.:.....|.:.:....            ...:..|..|....||.
Human   833 DWIIVLANGAIAEMGSYQELLQRKGALMCLLDQARQPGDRGEGETEPGTSTKDPRGTSAGRRPEL 897

  Fly   670 R--KSLSQEEHMDRHEIEQQF---------------KEQQQIGSVKLQTYKEYFKVLGHPLVVVL 717
            |  :|:......||...|.|.               |:..|.|.||...:..|.:.:|.|| .:.
Human   898 RRERSIKSVPEKDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRVKATVHLAYLRAVGTPL-CLY 961

  Fly   718 ILLMFVVARSSEATMDIFLSKWATWEETEPNQHEPIPEYHRTRLRMMILYTFLILCTLIFYVLRT 782
            .|.:|:..:.:......:||.||         .:|.....:|:..:......|:.|      |:.
Human   962 ALFLFLCQQVASFCRGYWLSLWA---------DDPAVGGQQTQAALRGGIFGLLGC------LQA 1011

  Fly   783 FGFFMMTLRISL---RIHDQLFQ----GVIRAFMHFFTLATSGRILNRFSSDVLAIDVNLPQAMM 840
            .|.|.....:.|   |....|||    .|:|:.:.||.....|.:|||||.:...:||::|..:.
Human  1012 IGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLR 1076

  Fly   841 DSIEFAVNALAVLAVVSTANIWLLIP-ATVVVA---LLY-GCRCLYIGASRSLKRIETISRSPIY 900
            ..:.:|...|.|..||:.|.     | |||.:.   ||| |.:.||:.:|..|:|:|:.|.|.:.
Human  1077 SLLMYAFGLLEVSLVVAVAT-----PLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVC 1136

  Fly   901 SHTNATFKGLATIRALNGTKYMERDFHYYQNENTSALYLHVSINRAFAFWTDLICVLYILAVTFS 965
            ||...||:|...:||...........:...:|:....:..:..:|..|...:|:....:.|....
Human  1137 SHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATC 1201

  Fly   966 FLLFDKHRGYYSGDVGLAITQSMKLVLMCQAGMRQTVELENMMTSVERVMEYVNIPSEPAYETEE 1030
            .:|...|..  :|.||.:::.::::....|..:|...:|||.:.||||:.:|...|.|..:....
Human  1202 AVLSKAHLS--AGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPT 1264

  Fly  1031 SVNLPKHWPSGGQLDFRDLRLRYSNHGPYILKGLTFTIRGEEKIGIVGHTAAGKSSIVHALFRLA 1095
            ....|. ||.|||::|||..|||....|..::|::|.|...||:||||.|.|||||:...|.||.
Human  1265 CAAQPP-WPQGGQIEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQ 1328

  Fly  1096 H-INGHISIDGFETSQLGLHDLRRRISIIPQDPVLFSGSLRFNLDPFEEKTDEELWLALEAVKLK 1159
            . ..|.|.|||...:.:|||.||.|||||||||:||.||||.|||..:|.:||.:|.|||.|:||
Human  1329 EAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLK 1393

  Fly  1160 EFVSNLKDGINCRLHDCGANFSMGQRQLVCLARALLRQNKILIMDEATANVDPETDNLIQEAIHT 1224
            ..|::|...:..:..|.|.:.|:||:||:||||||||:.:|||:|||||.|||.|:..:|..:.:
Human  1394 ALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGS 1458

  Fly  1225 KFAHCTVLTIAHRLHTVMDNDRVMVVDMGRVVELGHPHELLHNRHGYLHRFVEKTGV 1281
            .||.||||.|||||.:|||..||:|:|.|:|.|.|.|.:||..: |..:|..:::|:
Human  1459 WFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQK-GLFYRLAQESGL 1514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	418/1339 (31%)
		ABC_membrane	92..358	CDD:294371	67/275 (24%)
		ABCC_MRP_domain1	423..626	CDD:213217	83/204 (41%)
		ABC_membrane	762..988	CDD:294371	62/237 (26%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	117/219 (53%)
ABCC6	XP_024306029.1	SunT	14..1514	CDD:331423	421/1355 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151603
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.650