DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and MRP

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_723772.2	Gene:	MRP / 34686	FlyBaseID:	FBgn0032456	Length:	1549	Species:	Drosophila melanogaster

Alignment Length:	1383	Identity:	461/1383 - (33%)
Similarity:	725/1383 - (52%)	Gaps:	188/1383 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 QRQPN--PVTKANFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLGHWEQELK 69
            ||..|  |...|:|.|:..:.|..::.:||.:..|:..||::..|....::|......||.|.::
  Fly   218 QRGENEIPELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVR 282

  Fly    70 RSKPNVLRM---------------------------------IFKAYGWSFVPASIVYSIMAIAV 101
            ::..|..|:                                 |:|::|..|:..::: .:....:
  Fly   283 KNYKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALM-KLFTDTL 346

  Fly   102 HTTQPLMLGGLVSFFSESTGKITKHSAYLYAMGVVLC----SLISGLFFHPFMKYLFRVGSRVRL 162
            ...||.:|..::||. |:.....:....|||:.:.:.    :.|.|.:||    .:|.||.|:|.
  Fly   347 TFAQPQVLSLIISFV-EAQDAEPEWKGILYAVLLFVLAAAQTFILGQYFH----RMFIVGLRIRT 406

  Fly   163 ACAGLVYRKFLRVSVAADNSGVSGYAISLMATDLPTFNESFYCFHELWRGPLEGVVFVYIIYQLI 227
            |....:|||.||:|.:.......|..::|||.|...|.|.....:.:|..||:..:.:|.::|.:
  Fly   407 ALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQL 471

  Fly   228 GWPAVVGLGTIVAFIPLQAWAARAIARYKRSSADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKL 292
            |...:.||..::..||:....|..|..|:.......|||||||||:::.::::|:||||.||.|.
  Fly   472 GPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQ 536

  Fly   293 IGKVRKEEMDSIRGSTYIYAGLQCTGMISKLSLFL-SLV---TYVFTGDI--VTSQKVFIVASYY 351
            :..:|.:|:.::|.:.|:.||   |..:...:.|| |||   |||.|.:.  ::.:||.:..:.:
  Fly   537 VLDIRDKEIATLRSTAYLNAG---TSFLWSCAPFLVSLVTFATYVLTSEANQLSVEKVLVSIALF 598

  Fly   352 DHLNDSLLHSWPLAINMWVETFVVANRVKDFLFQHENPADGGVHNFKEAEDNP---EHGNFFGRT 413
            |.:...|.....|:::: .||.|..||:..||...|...:..:|:  .::.:|   |:|.|
  Fly   599 DLMKLPLTILPMLSVDI-AETQVSVNRINKFLNSEELDPNSVLHD--SSKPHPMSIENGEF---- 656

  Fly   414 HKPKAEVKSITVHKLSASWDQKKQEKRHRHIEDVSFQAQDQQFVGIVGTVGAGKSTLLQVILGEL 478
                             ||..:..      :.:::.:.:....|.:|||||:|||:::|..|||:
  Fly   657 -----------------SWGDEIT------LRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEM 698

  Fly   479 DIISGSVEVNGVLSYAPQEPWLLRGSLRDNILFTEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTR 543
            :.::|.|...|.|:|.||:.|:...::||||||.:.||.:||.:|:..|.|..|::.|..||.|.
  Fly   699 EKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTE 763

  Fly   544 VGEGGASLSGGQKARVSLARAVYRKADIYLLDDPLSAVDSHVSKMLLDRCLNE--FLSKKIRILV 606
            :||.|.:||||||.|:|||||||..||:|||||||||||:||.|.:.:..:..  .|::|.|:||
  Fly   764 IGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLV 828

  Fly   607 THRVQLLRHVDHLVLLEGGRISVQGHYDALKK----------------------LIRFRMSVAND 649
            ||.|..|..||.:.:::.|.||..|.:|.|.|                      |.:.:..:::.
  Fly   829 THGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQISST 893

  Fly   650 VEVAKL--------RAMRTDSVYEEPE--------------PRKSLSQEEH---------MDRHE 683
            .:|.:|        :..||:|:.:...              .|::..|:.|         ..:.|
  Fly   894 ADVPELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKKQE 958

  Fly   684 IEQQF--KEQQQIGSVKLQTYKEYFKVLGHPLVVVLILLMFVVARSSEATMDIFLSKWATWEETE 746
            :|.:.  .|:.|.|.|:...||.|.|.:|..|.|..::|.||. ::.:...:::|::||. ::..
  Fly   959 VEGKLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVF-QAFQIGSNLWLTQWAN-DQNV 1021

  Fly   747 PNQHEPIPEYHRTRLRMMILYTFLILCTLIFYVLRTFGF-------------FMMTLRISLRIHD 798
            .|.         |.||.|.|           .|...|||             ::...:.:..||:
  Fly  1022 AND---------TGLRDMYL-----------GVYGAFGFGQGVLAYFAVVIVYLGGFQAAKTIHN 1066

  Fly   799 QLFQGVIR-AFMHFFTLATSGRILNRFSSDVLAIDVNLPQAMMDSIEFAVNALAVLAVVSTANIW 862
            :|...:|| :...||.:...||:||.||.|:..:|..||..|...:.|....||.:.|:|.:...
  Fly  1067 ELLAVIIRGSVCRFFDITPIGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVVISLSTPI 1131

  Fly   863 LLIPATVVVALLYGCRCLYIGASRSLKRIETISRSPIYSHTNATFKGLATIRALN-GTKYMERDF 926
            .|.....:..|.|..:..|:..||.|.|:|::||||||||.:.|..|.:||||.| |.:::| :.
  Fly  1132 FLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIE-ES 1195

  Fly   927 HYYQNENTSALYLHVSINRAFAFWTDLICVLYIL-AVTFSFLLFDKHRGYYSGDVGLAITQSMKL 990
            ....::|....|..|..||..|...:::..|.|| |..|:.|....:.|.    |||:::.::::
  Fly  1196 DAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVLGGQTNPGL----VGLSVSYALQV 1256

  Fly   991 VLMCQAGMRQTVELENMMTSVERVMEYVNIPSEPAYETEESVNLPKHWPSGGQLDFRDLRLRYSN 1055
            .......:|.:.::|..:.||||:.||.....|..:|.|:..|.||:||..|:::|::.::||..
  Fly  1257 TQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYRE 1321

  Fly  1056 HGPYILKGLTFTIRGEEKIGIVGHTAAGKSSIVHALFRLAH-INGHISIDGFETSQLGLHDLRRR 1119
            ....:|:|::|.|:|.||:||||.|.|||||:..||||:.. ..|.|||||.:.:.:|||.||.|
  Fly  1322 GLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSR 1386

  Fly  1120 ISIIPQDPVLFSGSLRFNLDPFEEKTDEELWLALEAVKLKEFVSNLKDGINCRLHDCGANFSMGQ 1184
            ::||||||||||||||.||||||.|||:|:|.|||...||.||.:|..|:|..:.:.|.|.|:||
  Fly  1387 LTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQ 1451

  Fly  1185 RQLVCLARALLRQNKILIMDEATANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMV 1249
            ||||||||||||:.|:|::|||||.||.|||:|||:.|.|:|..||||||||||:|::|:|:|:|
  Fly  1452 RQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIV 1516

  Fly  1250 VDMGRVVELGHPHELLHN 1267
            :|.|:::|...|.|||.|
  Fly  1517 LDKGQIIEFASPTELLDN 1534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	459/1381 (33%)
		ABC_membrane	92..358	CDD:294371	81/275 (29%)
		ABCC_MRP_domain1	423..626	CDD:213217	85/204 (42%)
		ABC_membrane	762..988	CDD:294371	72/241 (30%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	125/219 (57%)
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	461/1383 (33%)
		ABC_membrane	338..601	CDD:279056	81/271 (30%)
		ABCC_MRP_domain1	649..848	CDD:213217	88/225 (39%)
		ABC_membrane	988..1260	CDD:279056	83/298 (28%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	125/219 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440904
Domainoid	1	1.000	173	1.000	Domainoid score	I751
eggNOG	1	0.900	-	-		E2759_KOG0054
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	133	1.000	Inparanoid score	I246
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	P	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.800