DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and Sur

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_001334732.1	Gene:	Sur / 34350	FlyBaseID:	FBgn0028675	Length:	2223	Species:	Drosophila melanogaster

Alignment Length:	2021	Identity:	396/2021 - (19%)
Similarity:	679/2021 - (33%)	Gaps:	786/2021 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 ANFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLGHWEQEL-----KRSKPNV 75
            |.|:||..|.|...:|..|.:..|:..||.:.:  ||.:..|     |::..|     |:.|.|.
  Fly   226 ATFYSKSCFWWLTPLLWLGYKEPLELEDLGQMK--LEDSARS-----HYDHFLYIYTEKKKKSNS 283

  Fly    76 LRMIFKAY---GWSFVPASIVYSIMAIAVHTTQPLMLGGLVSF---------------------- 115
            ...::..|   .|.......:..:.........||.:..:|.:
  Fly   284 SPSLWYCYIKNSWQMFALGGILKLAGDLFALIGPLAIQKIVEYIEQLYAQASEPPAKSPGNEVAN 348

  Fly   116 ------------FSESTG-KITKHSAY------LYAMG------VVLCSLISGLFFHPFMKYLFR 155
                        |.|..| .|.|...|      |.|.|      |:|.::..|.........|..
  Fly   349 VLLSTSRILGTEFDEVFGTNIDKVRIYSSTWSDLLANGWCIAWIVLLAAITQGALSQASTHILNM 413

  Fly   156 VGSRVRLACAGLVYRKFLRVSV--AADNSGVSGYAISLMAT------------------------ 194
            .|.|::.:..||:|||.|.::.  ..|:|..:|...|..:|
  Fly   414 TGIRIKTSLQGLIYRKSLLLNADGGCDSSDSAGQVQSTSSTSDEKQKNDDSMATPEHVDNPSEPN 478

  Fly   195 --------------DLPTFNESFYCFHELWRGPLEGVVFVYIIYQLIGWPAVVG-LGTIVAFIPL 244
                          |.....|.|...|..|..|.:..|.:|::|..:|..||:| :..||...||
  Fly   479 ISHDIGSITNHMTEDTRNIMEFFLIIHYAWAIPFKIAVVIYLLYMNLGISAVIGSIACIVIMTPL 543

  Fly   245 QAWAARAIARYKRSSADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSI-RGST 308
            |.:...|:::.....|...|||:|.:::.:..:::||:.||::.|.|.|.:.|::|:..: :.:|
  Fly   544 QFFIGNAMSKNAEVIAGYTDERLKRIHDTLVGIKVIKLNAWDEVFLKKIQEARRKELKYLNKDAT 608

  Fly   309 YIYAGLQCTGMISKLSLFLSLVTYVFTG-----DIVTSQKVFIVASYYDHLNDSLLHSWPLAINM 368
            :.......|.:.:.|..|::|..||:..     |: .:.::|...:.:..|...|| .:|:.:.:
  Fly   609 FWTLMAVLTHIATVLITFVTLGVYVWLHRDQEFDL-NASRLFSSLALFQQLTVPLL-IFPITVPI 671

  Fly   369 WVETFVVANRVKDFLFQHE---------------NPADGGVHNFK------------EAEDNPEH 406
            .:...|...|::.||...|               :.:|..:..::            :||:....
  Fly   672 IIAARVSTRRLERFLKSSEIQKQFEGIRNMARILSKSDASLDMYETQEKSNMTMRTAQAENRLNE 736

  Fly   407 GNFFGRTHKPK----------------AEVKSITVHKLSASWDQKKQEKR--------------- 440
            .....::..|:                .::...||.:|  ..::..|::|
  Fly   737 KRLAQKSQTPELATNSTPLLQNAEESAEDISPSTVQEL--GHNKLVQQRRELLRNTPYVAIRPPK 799

  Fly   441 ------HRHIE-----------------------DVSFQAQDQQFVG------------------ 458
                  .|.:|                       |::....|..|..
  Fly   800 MRGSVMERPVEFSVIRARNTDSWRRDSLLLKMPDDIAVSINDGLFTWQPQSQMPVVQLHVPGIIV 864

  Fly   459 -------IVGTVGAGKSTLLQVILGELDIISGSV--EVNGVLSYAPQEPWLLRGSLRDNILFTEP 514
                   :||..|:||::||..:|.|:.:::|::  .....:||..|:||||..::|:||||.|.
  Fly   865 PKGKLTIVVGKNGSGKTSLLSALLMEMPLLAGNMFWHKTCTISYVSQQPWLLNDTIRENILFGES 929

  Fly   515 YDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLARAVYRKADIYLLDDPLS 579
            :..:||..||..|.|..|:|.:|.||.:.:||.|.::||||:.|:::|||:|..|::.::||||:
  Fly   930 FRPKRYDFVLEACALKPDIELMPRGDLSIIGERGINISGGQRQRIAIARAIYSSANVVIMDDPLA 994

  Fly   580 AVDSHVSKMLLDRCLNEFLSKKIR--ILVTHRVQLLRHVDHLVLLEGGRISVQGHYDALK----- 637
            ::|:.|.:.:...|:.|.|.|..|  ||||.::..::..::|:.::.||:...|.|..::
  Fly   995 SLDNEVGEHIFQHCIREMLQKSNRTFILVTQQLHRIKEAEYLIAIKDGRVEACGSYADIELMQPR 1059

  Fly   638 --------------------------------KLIR----------------------------- 641
                                            ||::
  Fly  1060 ITAEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKLGLQRSISVTMDANVACHADAIDGS 1124

  Fly   642 --------------------------------FRM------------------------------ 644
                                            |.:
  Fly  1125 GCISVANMQSNVVEEDDQVSVSYPIGNASCGGFNLQRKRSSIYGSRHLMYDVPLPIDECQGDDVI 1189

  Fly   645 ------------------------------------SVANDV----------------------- 650
                                                |::.||
  Fly  1190 MRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVLSRSVLATSCSSYAESSVDGGDL 1254

  Fly   651 ----------------------------------EVAK--------------------------- 654
                                              |||.
  Fly  1255 ATAAPEPRVQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKKSEEARRSNTSSESPLDDHVRGS 1319

  Fly   655 ----LRAM----------------RTDSV---------------------------YEEPEPRKS 672
                ||.|                .|:|:                           ..|.:|:|.
  Fly  1320 FQQFLRRMSMRRSNKPKNHHHPLSATNSILSISEESPPVVHFPASILATDGNKNETQSEEKPKKC 1384

  Fly   673 LS--------------------------------QEEHMDRHEIEQQFKE--------------- 690
            ::                                ||:|.:||.:.:...|
  Fly  1385 VNIDSKETTINCDDNCYSASDKELRANVTSSPADQEQHNERHVLAEVAGESGRESMPLARLAIDT 1449

  Fly   691 QQQIGSVKLQTYKEYFKVLGHPLVVVLILLMFVVARSSEATMDIFLSKWATWEETEPNQH----- 750
            :::.|.:....|..|.:..|.|::.:..:.. ::.:......||:|.:|:       |.|
  Fly  1450 ERKYGKISDDIYLMYIRAAGLPIITIFFITA-LIWQCLRVYTDIWLQQWS-------NVHGRVAS 1506

  Fly   751 ------EPIPEYHRTRLRMMILYTFLILCTLIFYVLRTFGFFMMTLRISLRIHDQLFQGVIRAFM 809
                  .|..:.|.......:......:|.::..|....|.: ........:||:|.|.::...:
  Fly  1507 KGHVVLHPSEQDHEVTYYFRMYAAISCVCIIMALVSTPAGQY-AGCNARRNLHDKLLQTILHKTL 1570

  Fly   810 HFFTLATSGRILNRFSSDVLAIDVNLPQAMMDSIEFAVNALAVLAVVSTANIWLLIPATVVVALL 874
            |||.:...|||:||||:|:..||..:.......::|.:..|:.:.:..|...|:|:....:....
  Fly  1571 HFFQVTPLGRIVNRFSNDMAVIDKKIAATGQRLLQFTLLCLSAILINVTITPWILVLTLPICGAY 1635

  Fly   875 YGCRCLYIGASRSLKRIETISRSPIYSHTNATFKGLATIRALNGT--------KYMERDFHYYQN 931
            |..:..|..::|.|:|||..:.||:.||.:.|.:|:.||||.|..        |.:|.:...|..
  Fly  1636 YLIQKFYRCSARELQRIENATNSPVISHLSETIQGVTTIRAFNQQTRFTEILFKRLEANTIAYAL 1700

  Fly   932 ENTSALYLHVSINRAFAFWTDLI--CVLYILAVTFSFLLFDKHRGYYSGD--------------- 979
            .|||..:|.||:        |.:  |::::..||.........|.:|...
  Fly  1701 LNTSHRWLGVSL--------DYLGGCIVFVATVTALTAASVSCRRHYEATTSPSASASPSPFETY 1757

  Fly   980 ---------------VGLAITQSMKLVLMCQAGMRQTVELENMMTSVERVMEY------------ 1017
                           |||||..::.:.:.....::...::|....||||:..|
  Fly  1758 AVTKSPSELRPSPSLVGLAINYTLLVPIYLNWVVKLLADMEMYAGSVERIAHYAQGQDADADADA 1822

  Fly  1018 ----------------------------------------------------------------- 1017

  Fly  1823 DADADVDADLDHEPSSNEDVSAEVDRSSQSDAGDKVYPGATTAAGDVDEDGDQQRIGGARGGGGD 1887

  Fly  1018 ----------------------------------------------------------------- 1017

  Fly  1888 CGYRQGHENGAEANADKLNAGNVTGDGNHLNFHHPPATAGDKVEQATTKTSVIKDKQLPPQQDDK 1952

  Fly  1018 ---VNIPSEPAYETEESVNLPKHWPSGGQLDFRDLRLRYSNHGPYILKGLTFTIRGEEKIGIVGH 1079
               |.:|:|||.:.|...::|..||..|.:.|.::.|||......::..||..|...::|||.|.
  Fly  1953 DKKVVLPNEPARKLERYQSVPISWPQRGDIHFDNVSLRYEGQKQNVISNLTLKIPAGQRIGICGR 2017

  Fly  1080 TAAGKSSIVHALFR-LAHINGHISIDGFETSQLGLHDLRRRISIIPQDPVLFSGSLRFNLDPFEE 1143
            |.:||||:..:||. |....|||.||..:..::...:||.|:||||||..||:.::|.||||...
  Fly  2018 TGSGKSSLGLSLFGVLQTTRGHIYIDDVDIQRIRPDELRTRLSIIPQDVHLFNATIRENLDPHGY 2082

  Fly  1144 KTDEELWLALEAVKLKEFVS-NLKDGINCRLHDCGANFSMGQRQLVCLARALLRQNKILIMDEAT 1207
            ..|.:||..||..:|||||: :|..|::..:.|.|.|.|.|.|||:|||||:||.:..|::||||
  Fly  2083 FQDLQLWNCLELAQLKEFVNGHLPLGLDTVICDGGLNLSAGHRQLLCLARAILRGSVCLVLDEAT 2147

  Fly  1208 ANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGRVVELGHPHELLHNRHGYL 1272
            :.:|..|::.:.:|....|...|::||||||.|::|.||::|:|.||:||.|:|.||........
  Fly  2148 SVLDSSTESALLKAADLAFRGRTIITIAHRLTTILDYDRLIVLDQGRIVEDGNPRELQQLEGSVF 2212

  Fly  1273 HRFVEK 1278
            ...:||
  Fly  2213 RGLLEK 2218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	394/2009 (20%)
		ABC_membrane	92..358	CDD:294371	72/359 (20%)
		ABCC_MRP_domain1	423..626	CDD:213217	73/275 (27%)
		ABC_membrane	762..988	CDD:294371	63/265 (24%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	95/220 (43%)
Sur	NP_001334732.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	133	1.000	Inparanoid score	I246
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.160